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  • MEDLINE/PubMed (NLM)  (1,284)
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  • 1
    In: Pigment Cell & Melanoma Research, September 2015, Vol.28(5), pp.488-489
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/pcmr.12389/abstract Byline: Peter Dietrich, Anja Katrin Bosserhoff ***** No abstract is available for this article. ***** Article Note: Coverage on: Shoshan E, Mobley AK, Braeuer RR, Kamiya T, Huang L, Vasquez ME, Salameh A, Lee HJ, Kim SJ, Ivan C, Velazquez-Torres G, Nip KM, Zhu K, Brooks D, Jones SJ, Birol I, Mosqueda M, Wen YY, Eterovic AK, Sood AK, Hwu P, Gershenwald JE, Robertson AG, Calin GA, Markel G, Fidler IJ, Bar-Eli M. (2015) Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis. Nat. Cell Biol. 17(3), 311-321. doi: 10.1038/ncb3110.
    Keywords: Melanoma ; Microrna;
    ISSN: 1755-1471
    E-ISSN: 1755-148X
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  • 2
    Language: English
    In: Best Practice & Research Clinical Gastroenterology, August 2014, Vol.28(4), pp.637-653
    Description: Nonalcoholic fatty liver disease (NAFLD) is now recognized as the most common cause of chronic liver disease worldwide. Its prevalence has increased to more than 30% of adults in developed countries and its incidence is still rising. The majority of patients with NAFLD have simple steatosis but in up to one third of patients, NAFLD progresses to its more severe form nonalcoholic steatohepatitis (NASH). NASH is characterized by liver inflammation and injury thereby determining the risk to develop liver fibrosis and cancer. NAFLD is considered the hepatic manifestation of the metabolic syndrome. However, the liver is not only a passive target but affects the pathogenesis of the metabolic syndrome and its complications. Conversely, pathophysiological changes in other organs such as in the adipose tissue, the intestinal barrier or the immune system have been identified as triggers and promoters of NAFLD progression. This article details the pathogenesis of NAFLD along with the current state of its diagnosis and treatment.
    Keywords: Nonalcoholic Fatty Liver Disease (Nafld) ; Nonalcoholic Steatohepatitis (Nash) ; Metabolic Syndrome ; Medicine
    ISSN: 1521-6918
    E-ISSN: 1532-1916
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  • 3
    In: Pigment Cell & Melanoma Research, May 2018, Vol.31(3), pp.350-351
    Description: Byline: Peter Dietrich,Anja Katrin Bosserhoff ***** No abstract is available for this article. ***** Article Note: Coverage on: Gilot, D., Migault, M., Bachelot, L., Journe, F., Rogiers, A., Donnou-Fournet, E., Mogha, A., Mouchet, N., Pinel-Marie, M.-L., Mari, B., Montier, T., Corre, S., Gautron, A., Rambow, F., El Hajj, P., Ben Jouira, R., Tartare-Deckert, S., Marine, J.-C., Felden, B., Ghanem, G., Galibert, M.-D. (2017). A noncoding function of TYRP1 mRNA promotes melanoma growth. Nature Cell Biology Oct 9. https://doi.org/10.1038/ncb3623.
    Keywords: Tumors ; Melanoma ; Cells (Biology) ; Microrna;
    ISSN: 1755-1471
    E-ISSN: 1755-148X
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  • 4
    In: Pigment Cell & Melanoma Research, July 2016, Vol.29(4), pp.399-401
    Description: Byline: Peter Dietrich, Anja Katrin Bosserhoff ***** No abstract is available for this article. ***** Article Note: Coverage on: Micevic, G., Muthusamy, V., Damsky, W., Theodosakis, N., Liu, X., Meeth, K., Wingrove, E., Santhanakrishnan, M., and Bosenberg, M. (2016). DNMT3b modulates melanoma growth by controlling levels of mTORC2 component RICTOR. Cell Rep. 14(9), 2180-2192.
    Keywords: DNA (Cytosine-5-)-Methyltransferases–Physiology ; Humans–Physiology ; Mechanistic Target of Rapamycin Complex 2–Physiology ; DNA (Cytosine-5-)-Methyltransferases ; DNA Methyltransferase 3b ; Mechanistic Target of Rapamycin Complex 2;
    ISSN: 1755-1471
    E-ISSN: 1755-148X
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  • 5
    Language: English
    In: Journal of Contaminant Hydrology, 2011, Vol.122(1), pp.1-15
    Description: Measuring contaminant flow rates at control cross sections is the most accurate method to evaluate natural attenuation processes in the saturated subsurface. In most instances, point scale measurement is the method of choice due to practical reasons and cost factors. However, at many field sites, the monitoring network is too sparse for a reliable estimation of contaminant and groundwater flow rates. Therefore, integral pumping tests have been developed as an alternative. In this study, we compare mass flow rates obtained by integral pumping test results and point scale data. We compare results of both methods with regard to uncertainties due to estimation errors and mass flow estimations based on two different point scale networks. The differences between benzene and groundwater flow rate estimates resulting from point scale samples and integral pumping tests were 6.44% and 6.97%, respectively, demonstrating the applicability of both methods at the site. Point scale-based data, especially with use of cost efficient Direct-Push technique, can be applied to show the contaminant distribution at a site and may be followed by a denser point scale network or an integral method. Nevertheless, a combination of both methods decreases uncertainties.
    Keywords: Integral Pumping Test ; Point Scale Measurements ; Cstream ; Mass Flow Rate ; Btex ; Direct-Push ; Engineering ; Environmental Sciences ; Geography
    ISSN: 0169-7722
    E-ISSN: 1873-6009
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  • 6
    In: Ground Water, May 2012, Vol.50(3), pp.450-456
    Description: Detailed information on vertical variations in hydraulic conductivity () is essential to describe the dynamics of groundwater movement at contaminated sites or as input data used for modeling. values in high vertical resolution should be determined because tends to be more continuous in the horizontal than in the vertical direction. To determine in shallow unconsolidated sediments and in the vertical direction, the recently developed direct‐push injection logger can be used. The information obtained by this method serves as a proxy for and has to be calibrated to obtain quantitative values of measured vertical profiles. In this study, we performed direct‐push soil sampling, sieve analyses and direct‐push slug tests to obtain values in vertical high resolution. Using the results of direct‐push slug tests, quantitative values obtained by the direct‐push injection logger could be determined successfully. The results of sieve analyses provided lower accordance with the logs due to the inherent limitations of the sieving method.
    Keywords: Hydrogeology ; Environmental Geology ; Aquifers ; Central Europe ; Elbe River ; Europe ; Experimental Studies ; Germany ; Granulometry ; Ground Water ; Hydraulic Conductivity ; Injection ; Measurement ; Mobility ; Pirna Germany ; Pollution ; Preferential Flow ; Sampling ; Saxony Germany ; Sediments ; Soils ; Unconsolidated Materials ; Variations;
    ISSN: 0017-467X
    E-ISSN: 1745-6584
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  • 7
    Language: English
    In: Gut, July 2018, Vol.67(7), pp.1328-1341
    Description: Sorafenib is the only effective therapy for advanced hepatocellular carcinoma (HCC). Combinatory approaches targeting mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK)- and phosphatidylinositol-4,5-bisphosphate-3-kinase (PI3K)/protein-kinase B(AKT) signalling yield major therapeutic improvements. RAS proteins regulate both RAF/MAPK and PI3K/AKT signalling. However, the most important RAS isoform in carcinogenesis, Kirsten rat sarcoma (KRAS), remains unexplored in HCC. Human HCC tissues and cell lines were used for expression and functional analysis. Sorafenib-resistant HCC cells were newly generated. RNA interference and the novel small molecule deltarasin were used for KRAS inhibition both in vitro and in a murine syngeneic orthotopic HCC model. Expression of wild type KRAS messenger RNA and protein was increased in HCC and correlated with extracellular-signal regulated kinase (ERK) activation, proliferation rate, advanced tumour size and poor patient survival. Bioinformatic analysis and reporter assays revealed that KRAS is a direct target of microRNA-622. This microRNA was downregulated in HCC, and functional analysis demonstrated that KRAS-suppression is the major mediator of its inhibitory effect on HCC proliferation. KRAS inhibition markedly suppressed RAF/ERK and PI3K/AKT signalling and proliferation and enhanced apoptosis of HCC cells in vitro and in vivo. Combinatory KRAS inhibition and sorafenib treatment revealed synergistic antitumorigenic effects in HCC. Sorafenib-resistant HCC cells showed elevated KRAS expression, and KRAS inhibition resensitised sorafenib-resistant cells to suppression of proliferation and induction of apoptosis. KRAS is dysregulated in HCC by loss of tumour-suppressive microRNA-622, contributing to tumour progression, sorafenib sensitivity and resistance. KRAS inhibition alone or in combination with sorafenib appears as novel promising therapeutic strategy for HCC.
    Keywords: Hepatocellular Carcinoma ; Molecular Mechanisms ; Antineoplastic Agents -- Therapeutic Use ; Carcinoma, Hepatocellular -- Metabolism ; Liver Neoplasms -- Metabolism ; Micrornas -- Metabolism ; Niacinamide -- Analogs & Derivatives ; Phenylurea Compounds -- Therapeutic Use ; Proto-Oncogene Proteins P21(Ras) -- Physiology
    ISSN: 00175749
    E-ISSN: 1468-3288
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  • 8
    In: Pigment Cell & Melanoma Research, September 2018, Vol.31(5), pp.614-629
    Description: The network of molecular players is similar when comparing neural crest‐derived, actively migrating melanoblasts to melanoma cells. However, melanoblasts are sensitive to differentiation‐initiating signals at their target site (epidermis), while melanoma cells maintain migratory and undifferentiated features. We aimed at identifying downregulated genes in melanoma that are particularly upregulated in melanoblasts. Loss of such genes could contribute to stabilization of a dedifferentiated, malignant phenotype in melanoma. We determined that micro‐622 (miR‐622) expression was strongly downregulated in melanoma cells and tissues compared to melanocytes and melanoblast‐related cells. miR‐622 expression correlated with survival of patients with melanoma. miR‐622 re‐expression inhibited clonogenicity, proliferation, and migration in melanoma. Inhibition of miR‐622 in melanocytes induced enhanced migration. Kirsten rat sarcoma () was identified as a major functional target of miR‐622 in melanoma. We conclude that miR‐622 is a novel tumor suppressor in melanoma and identify the miR‐622‐ axis as potential therapeutic target.
    Keywords: Kras ; Melanoma ; Micro Rna
    ISSN: 1755-1471
    E-ISSN: 1755-148X
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  • 9
    In: Groundwater, November 2012, Vol.50(6), pp.935-942
    Description: Knowledge of site‐specific contaminant transport processes is an essential requirement for performing various tasks concerning the protection and management of groundwater resources. However, prediction of their behavior is often difficult, especially in heterogeneous aquifers because of the lack of information about flow‐ and transport‐governing subsurface structures and parameters. Hence, stochastic approaches have been developed and frequently used. However, extensive modeling studies on sedimentary structures have shown that consideration of hydrogeological subunits and their distribution can be essential for transport modeling. A case study from the intensely investigated Lauswiesen site is used to demonstrate that more accurate predictions are possible with improved knowledge of deterministic structures. Results of this case study using direct‐push injection logging (DPIL) provide a more reliable characterization of hydraulic conductivity than sieve and flow meter data.
    Keywords: Hydrogeology ; Environmental Geology ; Alluvium Aquifers ; Aquifers ; Baden-Wurttemberg Germany ; Central Europe ; Characterization ; Cluster Analysis ; Europe ; Experimental Studies ; Germany ; Ground Water ; Heterogeneous Materials ; Hydraulic Conductivity ; Lauswiesen Site ; Models ; Neckar River ; Permeability ; Pollutants ; Pollution ; Porous Materials ; Preferential Flow ; Pump Tests ; Statistical Analysis ; Stochastic Processes ; Transport ; Tubingen Germany ; Univariate Analysis;
    ISSN: 0017-467X
    E-ISSN: 1745-6584
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  • 10
    Language: English
    In: Gut, 12 August 2011, Vol.60(8), p.1122
    Description: Splanchnic vasodilation triggers the development of the hyperdynamic circulatory syndrome in portal hypertension. Neuropeptide Y (NPY), a sympathetic co-transmitter of norepinephrine, improves contractility in mesenteric arteries of pre-hepatic portal hypertensive rats. Therefore, we investigated the effect of NPY on mesenteric arterial contractility in vitro and in vivo in cirrhotic ascitic rats, as well as the vasoactive pathways involved.
    Keywords: Portal Hypertension ; Splanchnic Circulation ; Neuropeptide Y ; Rho-Kinase ; No ; Gastrointestinal Blood Flow ; Hepatic Haemodynamics ; Liver Cirrhosis ; Portal Hypertension
    ISSN: 0017-5749
    ISSN: 00175749
    E-ISSN: 1468-3288
    E-ISSN: 14683288
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