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  • MEDLINE/PubMed (NLM)  (14)
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  • 1
    Language: English
    In: PLoS One, San Francisco: Public Library of Science
    Description: Article discussing the bacterial composition of subgingival plaque among diabetic and non-diabetic subjects to determine the effect that diabetes mellitus has on dental health.
    Keywords: Periodontiitis ; Bacteria ; Diabetes ; Pyrosequencing
    ISSN: 19326203
    E-ISSN: 19326203
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  • 2
    Language: English
    In: PLoS One, San Francisco: Public Library of Science
    Description: Article discussing a study that was conducted to understand the basis of a bacterial infection that is common among dairy cows.
    Keywords: Dairy ; Cows ; Pyrosequencing ; Amplicons ; Bacteria ; Microbiology
    ISSN: 19326203
    E-ISSN: 19326203
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  • 3
    Language: English
    In: PLoS ONE, 2012, Vol.7(5), p.e36298
    Description: Lactobacillus- dominated vaginal microbiotas are associated with reproductive health and STI resistance in women, whereas altered microbiotas are associated with bacterial vaginosis (BV), STI risk and poor reproductive outcomes. Putative vaginal taxa have been observed in male first-catch urine, urethral swab and coronal sulcus (CS) specimens but the significance of these observations is unclear. We used 16 S rRNA sequencing to characterize the microbiota of the CS and urine collected from 18 adolescent men over three consecutive months. CS microbiotas of most participants were more stable than their urine microbiotas and the composition of CS microbiotas were strongly influenced by circumcision. BV-associated taxa, including Atopobium , Megasphaera , Mobiluncus , Prevotella and Gemella , were detected in CS specimens from sexually experienced and inexperienced participants. In contrast, urine primarily contained taxa that were not abundant in CS specimens. Lactobacilllus and Streptococcus were major urine taxa but their abundance was inversely correlated. In contrast, Sneathia , Mycoplasma and Ureaplasma were only found in urine from sexually active participants. Thus, the CS and urine support stable and distinct bacterial communities. Finally, our results suggest that the penis and the urethra can be colonized by a variety of BV-associated taxa and that some of these colonizations result from partnered sexual activity.
    Keywords: Research Article ; Biology ; Medicine ; Public Health And Epidemiology ; Infectious Diseases ; Microbiology ; Urology
    E-ISSN: 1932-6203
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  • 4
    Language: English
    In: Journal of Clinical Microbiology, pp. 1376-1383
    Description: Article on evidence of uncultivated bacteria in the adult female bladder.
    Keywords: Uropathogens ; Clinical Cultivation ; Uncultivated Bacteria ; Urinary Tract Conditions
    ISSN: 1098660X
    E-ISSN: 1098660X
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  • 5
    In: The ISME Journal, 2012, Vol.7(1), p.221
    Description: Bacterial community composition in blood-sucking arthropods can shift dramatically across time and space. We used 16S rRNA gene amplification and pyrosequencing to investigate the relative impact of vertebrate host-related, arthropod-related and environmental factors on bacterial community composition in fleas and ticks collected from rodents in southern Indiana (USA). Bacterial community composition was largely affected by arthropod identity, but not by the rodent host or environmental conditions. Specifically, the arthropod group (fleas vs ticks) determined the community composition of bacteria, where bacterial communities of ticks were less diverse and more dependent on arthropod traits--especially tick species and life stage--than bacterial communities of fleas. Our data suggest that both arthropod life histories and the presence of arthropod-specific endosymbionts may mask the effects of the vertebrate host and its environment.
    Keywords: Biology;
    ISSN: 1751-7362
    E-ISSN: 17517370
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  • 6
    Language: English
    In: Journal of Chromatography B, 2011, Vol.879(20), pp.1741-1747
    Description: Norcantharidin (NCTD), the demethylated analogue of cantharidin, inhibits the proliferation of a variety of human tumor cell lines, and appears to cause the least nephrotoxic and inflammatory side effects. Although NCTD has been used to treat human cancers in China for years, there is no report regarding its metabolism up to now. This is the first report to separate and identify the main metabolites of NCTD in vivo by GC–MS using TMS derivatives. Two hydrolyzed products and five phase I or phase II metabolites were found in rat by the chromatogram comparisons of the blank with incurred biological samples. Multiple stages of fragmentation patterns were used to confirm the metabolites characterizations. The established GC–MS method can also be applied to identifying unknown metabolites of the drugs containing hydroxyl or carbonyl groups in molecular structure.
    Keywords: Norcantharidin ; Metabolites ; Gc–MS ; Derivate ; Metabolism ; Anatomy & Physiology
    ISSN: 1570-0232
    E-ISSN: 1873-376X
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  • 7
    Language: English
    In: The American Journal of Pathology
    Description: With the rapid development of image scanning techniques and visualization software, whole slide imaging (WSI) is becoming a routine diagnostic method. Accelerating clinical diagnosis from pathology images and automating image analysis efficiently and accurately remain significant challenges. Recently, deep learning algorithms have shown great promise in pathology image analysis, such as in tumor region identification, metastasis detection, and patient prognosis. Many machine learning algorithms, including convolutional neural networks, have been proposed to automatically segment pathology images. Among these algorithms, segmentation deep learning algorithms such as fully convolutional networks stand out for their accuracy, computational efficiency, and generalizability. Thus, deep learning–based pathology image segmentation has become an important tool in WSI analysis. In this review, the pathology image segmentation process using deep learning algorithms is described in detail. The goals are to provide quick guidance for implementing deep learning into pathology image analysis and to provide some potential ways of further improving segmentation performance. Although there have been previous reviews on using machine learning methods in digital pathology image analysis, this is the first in-depth review of the applications of deep learning algorithms for segmentation in WSI analysis.
    Keywords: Medicine
    ISSN: 0002-9440
    E-ISSN: 1525-2191
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  • 8
    Language: English
    In: Cancers, 01 October 2019, Vol.11(11), p.1673
    Description: Objective: Accurate diagnosis and prognosis are essential in lung cancer treatment selection and planning. With the rapid advance of medical imaging technology, whole slide imaging (WSI) in pathology is becoming a routine clinical procedure. An interplay of needs and challenges exists for computer-aided...
    Keywords: Lung Cancer ; Deep Learning ; Pathology Image ; Computer-Aided Diagnosis ; Digital Pathology ; Whole-Slide Imaging ; Medicine
    E-ISSN: 2072-6694
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  • 9
    In: Biomedical Chromatography, November 2013, Vol.27(11), pp.1398-1405
    Description: Bergenin is the major component of and with many biological activities. Although bergenin has been used to treat human diseases in China for man years, there is no report regarding its metabolism. This is the first report to separate and identify the metabolites of bergenin . In the study, HPLC/Q‐TOF‐MS/MS was used to investigate the metabolites of bergenin by analyzing the rat body fluid and feces samples. Three metabolites of bergenin were finally identified by the TIC chromatograms, and the structures were also confirmed by their MS spectra. Copyright © 2013 John Wiley & Sons, Ltd.
    Keywords: Bergenin ; In Vivo ; Metabolites ; Hplc/Q‐Tof‐Ms/Ms
    ISSN: 0269-3879
    E-ISSN: 1099-0801
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  • 10
    In: Clinical Pharmacology in Drug Development, March 2018, Vol.7(3), pp.256-262
    Description: This study was designed to investigate the pharmacokinetics of an innovative film‐coated warfarin sodium tablet and to compare it with the marketed sugar‐coated warfarin sodium tablet in humans. A single‐dose, open‐label, randomized, two‐way crossover study was performed in 24 healthy Chinese male volunteers. They were administered 2.5 mg of innovative film‐coated warfarin sodium tablets or the marketed sugar‐coated warfarin sodium tablets. Blood samples were collected at different time points after dosing for investigation of the pharmacokinetics of warfarin in human plasma. A sensitive liquid chromatography mass spectrometry method was established to determine warfarin in plasma. Drug and Statistics 2.1.1 was applied to calculate the pharmacokinetics parameters. The main pharmacokinetic parameters for film‐coated and sugar‐coated warfarin were the following: t, 103.5 ± 18.8 and 105.8 ± 21.3 hours; T, 0.7 ± 0.5 and 1.3 ± 0.8 hours; C, 347.8 ± 74.8 and 322.9 ± 75.7 ng/mL; AUC, 16,024.2 ± 3713.9 and 15,586.6 ± 3477.0 ng·mL·h; AUC, 17,335.7 ± 4089.1 and 16,912.0 ± 3911.2 ng·mL·h, respectively. The human pharmacokinetics of film‐coated and sugar‐coated warfarin were slightly different. The oral absorption and bioavailability of innovative film‐coated warfarin were slightly higher than those of the sugar‐coated warfarin. This study is vital to clinical usage of warfarin not only because of the pharmacokinetic parameters of the 2 pharmaceutical dosage forms of warfarin but also to obtain data on the prevalence of CYP2C9 and VKORC1 genes and their influence on the concentration of warfarin.
    Keywords: Warfarin ; Pharmacokinetics ; Bioequivalence ; Gene Polymorphism ; Hplc‐Ms
    ISSN: 2160-763X
    E-ISSN: 2160-7648
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