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  • NARCIS (Royal Netherlands Academy of Arts and Sciences)  (27)
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  • 1
    Language: English
    In: Journal of Physiotherapy, January 2015, Vol.61(1), pp.42-42
    Description: Introduction: Non-pharmacological interventions such as mirror therapy are gaining increased recognition in the treatment of phantom limb pain; however, the evidence in people with phantom limb pain is still weak. In addition, compliance to self-delivered exercises is generally low. The aim of this randomised controlled study is to investigate the effectiveness of mirror therapy supported by telerehabilitation on the intensity, duration and frequency of phantom limb pain and limitations in daily activities compared to traditional mirror therapy and care as usual in people following lower limb amputation. Method: A three-arm multi-centre randomised controlled trial will be performed. Participants will be randomly assigned to care as usual, traditional mirror therapy or mirror therapy supported by telerehabilitation. During the first 4 weeks, at least 10 individual sessions will take place in every group. After the first 4 weeks, participants will be encouraged to perform self-delivered exercises over a period of 6 weeks. Outcomes will be assessed at 4 and 10 weeks after baseline and at 6 months follow-up. The primary outcome measure is the average intensity of phantom limb pain during the last week. Secondary outcome measures include the different dimensions of phantom limb pain, pain-related limitations in daily activities, global perceived effect, pain-specific self-efficacy, and quality of life. Discussion: Several questions concerning the study design that emerged during the preparation of this trial will be discussed. This will include how these questions were addressed and arguments for the choices that were made.
    Keywords: Physical Therapy
    ISSN: 1836-9553
    E-ISSN: 1836-9561
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  • 2
    Language: English
    In: Environmental Toxicology and Chemistry, 2001, Vol.20(9), p.2088
    Description: We studied the chronic effects of 4-nonylphenol (4-NP) on reproductive status of medaka (Oryzias latipes) over two generations of continuous exposure. The exposure study of the parental (F0) medaka was begun on embryos within 24 h post-fertilization and continued with monitoring through embryological development, hatching, posthatch survival, growth, sexual differentiation, and reproduction under flow-through exposures to mean measured 4-NP concentrations of 4.2, 8.2, 17.7, 51.5, and 183 µg/litre for up to 104 d. Eggs spawned from the F0 fish at 102 and 103 d posthatch were also examined for hatchability, survival after hatching, growth, and sexual differentiation until 60 d posthatch. The 183-µg/litre treatment significantly reduced the embryo survival and swim-up success of the F0 fish. The cumulative mortality after swim-up of the F0 fish exposed to 17.7 and 51.5 µg/litre were significantly higher than the control mortality. No concentration-related effect of 4-NP was observed on the growth of surviving F0 fish at 60 d posthatch. However, the sex ratio estimated from the appearance of their secondary sex characteristics was skewed toward female in the 51.5-µg/litre treatment. Additionally, gonadal histology showed that 20% of the fish in the 17.7-µg/litre treatment and 40% in the 51.5-µg/litre treatment had testis-ova, indicating that 4-NP affects the gonadal development and survival of medaka at similar concentrations in juveniles. The sex ratio of the F0 fish in the 51.5-µg/litre treatment was completely skewed toward female; subsequently, the effects on fecundity and fertility in this generation were monitored at mean measured concentrations of 4.2, 8.2, and 17.7 µg/litre from 71 to 103 d posthatch. Fecundity was unaffected by any of the treatments examined. The mean fertility in the 17.7-µg/litre treatment was reduced to 76% of that in the controls, although no statistically significant differences were determined. Overall, these results indicate that the lowest-observed-effect concentration (LOEC) and no-observed-effect concentration (NOEC) of 4-NP through the life cycle of the F0 medaka were 17.7 and 8.2 µg/litre, respectively. In the F1 medaka, no significant effects were observed on hatching success, posthatch mortality, or growth, but sexual differentiation at 60 d posthatch was affected. Induction of testis-ova in the gonads of the F1 fish was observed in both the 8.2- and the 17.7-µg/litre concentrations. The results indicate that 4-NP can have significant effects on reproductive potential of medaka at concentrations as low as 17.7 µg/litre.
    Keywords: Aquatic Animals ; Aquatic Organisms ; Embryonic Development ; Embryos ; Growth ; Mortality ; Nontarget Effects ; Ovaries ; Reproduction ; Sex Differentiation ; Survival ; Testes ; Toxic Substances ; Toxicity ; Toxicology ; Aquatic Species ; Death Rate ; Embryo Development ; Embryo Growth ; Nonylphenols ; Poisons ; Testicles ; Oryzias Latipes ; Oryzias ; Adrianichthyidae ; Beloniformes ; Osteichthyes ; Fishes ; Vertebrates ; Chordata ; Animals ; Eukaryotes;
    ISSN: 0730-7268
    E-ISSN: 1552-8618
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  • 3
    Language: English
    In: Environmental Science and Technology, 2019, Vol.53(7), pp.3347-3365
    Description: Fungicides are indispensable to global food security and their use is forecasted to intensify. Fungicides can reach aquatic ecosystems and occur in surface water bodies in agricultural catchments throughout the entire growing season due to their frequent, prophylactic application. However, in comparison to herbicides and insecticides, the exposure to and effects of fungicides have received less attention. We provide an overview of the risk of fungicides to aquatic ecosystems covering fungicide exposure (i.e., environmental fate, exposure modeling, and mitigation measures) as well as direct and indirect effects of fungicides on microorganisms, macrophytes, invertebrates, and vertebrates. We show that fungicides occur widely in aquatic systems, that the accuracy of predicted environmental concentrations is debatable, and that fungicide exposure can be effectively mitigated. We additionally demonstrate that fungicides can be highly toxic to a broad range of organisms and can pose a risk to aquatic biota. Finally, we outline central research gaps that currently challenge our ability to predict fungicide exposure and effects, promising research avenues, and shortcomings of the current environmental risk assessment for fungicides.
    Keywords: Alterra - Environmental Risk Assessment ; Environmental Risk Assessment ; Alterra - Environmental Risk Assessment ; Environmental Risk Assessment
    ISSN: 0013-936x
    ISSN: 0013936X
    E-ISSN: 15205851
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  • 4
    In: Journal of Advanced Nursing, July 2017, Vol.73(7), pp.1712-1721
    Keywords: Complications ; Kidney Transplantation ; Nursing ; Patient‐Reported Outcomes ; Perceived Control ; Psychological Distress
    ISSN: 0309-2402
    E-ISSN: 1365-2648
    Source: John Wiley & Sons, Inc.
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  • 5
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 09 July 2013, Vol.110(28), pp.11451-6
    Description: Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (〉20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to promote maternal tolerance toward fetal antigens. Here, we show that Gal-1 exhibits proangiogenic functions during early stages of pregnancy, promoting decidual vascular expansion through VEGF receptor 2 signaling. Blocking Gal-1-mediated angiogenesis or lectin, galactoside-binding, soluble, 1 deficiency results in a spontaneous PE-like syndrome in mice, mainly by deregulating processes associated with good placentation and maternal spiral artery remodeling. Consistent with these findings, we observed a down-regulation of Gal-1 in patients suffering from early onset PE. Collectively, these results strengthen the notion that Gal-1 is required for healthy gestation and highlight Gal-1 as a valuable biomarker for early PE diagnosis.
    Keywords: Galectin 1 -- Physiology ; Neovascularization, Physiologic -- Physiology ; Pre-Eclampsia -- Etiology
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 6
    Language: English
    In: Social Science & Medicine, October 2012, Vol.75(8), pp.1547-1554
    Description: Although kidney transplantation improves overall quality of life and physical functioning, improvements of psychological distress are often modest. However, apparent stressors such as comorbidity are only weakly associated with psychological distress and their impact differs considerably between patients. Wilson and Cleary proposed a theoretical model to explain these relationships. This model has been supported by research, but has never been applied in a population of kidney transplant recipients. Findings of the current study are based on a cross-sectional study carried out in 2008 in the northern Netherlands. An elaborated version of Wilson and Cleary’s model specifying hypothesized relationships of objective health, functional status, subjective health, personal characteristics and psychological distress was evaluated with structural equation modelling. After elimination of non-significant paths the final model provided a good fit for the data, (2) = 4.23, = 0.12; RMSEA = 0.047, CI (0; 0.11); ECVI = 0.060, ECVI = 0.059. Results suggest that objective health has an indirect effect on psychological distress, in size comparable to the effects exerted by functional status and subjective health. Personal characteristics are the strongest determinant of psychological distress, but are directly and indirectly affected by objective health. Results indicate that poor health might cause psychological distress by increasing coping demands while simultaneously decreasing coping resources. ► A comprehensive model of the interrelation of health and distress was tested and provided good fit for the data. ► Health has indirect effects on distress, mediated by functional status, subjective health and personal characteristics. ► Findings suggest that poor health leads to double strain by increasing disease burden and decreasing coping resources
    Keywords: The Netherlands ; Kidney Transplantation ; Mastery ; Optimism ; Self-Esteem ; Perceived Health Status ; Distress ; Comorbidity ; Medicine ; Social Sciences (General) ; Public Health
    ISSN: 0277-9536
    E-ISSN: 1873-5347
    Source: ScienceDirect Journals (Elsevier)
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  • 7
    Language: English
    In: Gastroenterology, April 2017, Vol.152(5), pp.S470-S470
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0016-5085(17)31765-1 Byline: Joachim Labenz, Henning G. Schulz, Andreas Leodolter, Jan B. Pedersen, Alejandro Nieponice, Ralf Weise, Nicole D. Bouvy
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
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  • 8
    Language: English
    In: Health Psychology, 2015, Vol.34(3), pp.270-273
    Description: Background: Recruitment of participants for studies focusing on couples facing illness is a challenging task and participation decline may be associated with nonrandom factors creating bias. This study examines whether patient and relationship characteristics are associated with partner participation in research. Method: Patients invited to participate in a cross-sectional study on adaptation and quality of life after renal transplantation were asked to forward information about an add-on study to their partners. Results: A total of 456 participating patients had a partner; 293 of the partners showed interest in the study and 206 actually completed the questionnaire. Backward logistic regression analyses revealed that demographic, illness, and personal characteristics of the patient were not associated with partner interest in the study nor actual partner participation. However, partners who indicated interest in the study showed more active engagement toward the patients (as reported by the patients). Furthermore, patients of partners who actually completed the questionnaire reported less negative affect and higher relationship satisfaction than patients whose partner did not participate in the study. Discussion: It is encouraging that of the large number of variables tested, only 2 were associated with the participation of partners. Nevertheless, well-functioning couples appear to be overrepresented in our study, calling for specific effort to include marital distressed couples in research focusing on dyadic adaptation to illness.
    Keywords: Couples ; Chronic Illness ; Generalizability ; Recruitment
    ISSN: 0278-6133
    E-ISSN: 1930-7810
    Source: PsycARTICLES (American Psychological Association)〈img src="http://exlibris-pub.s3.amazonaws.com/apaLogo2_134x31.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 9
    In: British Journal of Health Psychology, November 2014, Vol.19(4), pp.823-838
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/bjhp.12081/abstract Byline: Torben Schulz, Jan Niesing, Jaap J. Homan van der Heide, Ralf Westerhuis, Rutger J. Ploeg, Adelita V. Ranchor Keywords: expectation; distress; kidney transplantation; quality of life; psychological adjustment; optimism Objectives Previous research suggests that prior to kidney transplantation, patients overestimate their post-transplant quality of life (QoL). The current study aimed to corroborate these findings, identify determinants of QoL overestimation, examine its association with subsequent distress, and clarify the role of optimism. Design Prospective observational study. Methods Physical, psychological, and social QoL expectations, actual QoL, and distress (GHQ-12) of participants (56% male) were prospectively assessed before (T0; n = 228) and 3 (T1; n = 149), 6 (T2; n = 146), and 12 (T3; n = 114) months after successful transplantation. Results Patients who were treated with haemodialysis before transplantation reported greater physical QoL overestimation than those who received treatment with peritoneal dialysis. Neither physical nor social QoL overestimation at T1 was prospectively associated with increased distress at T2 or T3. The interaction between optimism and social QoL overestimation at T1 ([beta] = -.56, p .001) for distress at T2 was significant, with patients low in optimism experiencing more distress after QoL overestimation. Conclusions QoL overestimation is not associated with subsequent distress. Findings suggest that patients low in optimism are more vulnerable to distress following QoL overestimation. Statement of contribution What is already known on this subject? Kidney transplantation improves patients' quality of life. Prior to kidney transplantation, patients overestimate the scale of this improvement. What does this study add? Quality of life overestimation is not associated with subsequent distress. When optimism is low, kidney transplant recipients experience higher distress following quality of life overestimation.
    Keywords: Expectation ; Distress ; Kidney Transplantation ; Quality Of Life ; Psychological Adjustment ; Optimism
    ISSN: 1359-107X
    E-ISSN: 2044-8287
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  • 10
    Language: English
    In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, February 2012, Vol.26(2), pp.639-55
    Description: This study focused on the effects of short-term microgravity (22 s) on the gene expression and morphology of endothelial cells (ECs) and evaluated gravisensitive signaling elements. ECs were investigated during four German Space Agency (Deutsches Zentrum für Luft- und Raumfahrt) parabolic flight campaigns. Hoechst 33342 and acridine orange/ethidium bromide staining showed no signs of cell death in ECs after 31 parabolas (P31). Gene array analysis revealed 320 significantly regulated genes after the first parabola (P1) and P31. COL4A5, COL8A1, ITGA6, ITGA10, and ITGB3 mRNAs were down-regulated after P1. EDN1 and TNFRSF12A mRNAs were up-regulated. ADAM19, CARD8, CD40, GSN, PRKCA (all down-regulated after P1), and PRKAA1 (AMPKα1) mRNAs (up-regulated) provide a very early protective mechanism of cell survival induced by 22 s microgravity. The ABL2 gene was significantly up-regulated after P1 and P31, TUBB was slightly induced, but ACTA2 and VIM mRNAs were not changed. β-Tubulin immunofluorescence revealed a cytoplasmic rearrangement. Vibration had no effect. Hypergravity reduced CARD8, NOS3, VASH1, SERPINH1 (all P1), CAV2, ADAM19, TNFRSF12A, CD40, and ITGA6 (P31) mRNAs. These data suggest that microgravity alters the gene expression patterns and the cytoskeleton of ECs very early. Several gravisensitive signaling elements, such as AMPKα1 and integrins, are involved in the reaction of ECs to altered gravity.
    Keywords: Gene Expression Profiling ; Space Flight ; Endothelial Cells -- Metabolism ; Weightlessness -- Adverse Effects
    ISSN: 08926638
    E-ISSN: 1530-6860
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