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  • 1
    Language: German
    Description: Univ., Diss., 2010--Frankfurt (Main). Engl. Übers. des Hauptsacht.: Preclinical testing of nanoparticle based drug delivery systems on basis of human serum albumin for targeted drug delivery.
    Source: Networked Digital Library of Theses and Dissertations
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  • 2
    Language: German
    Description: Med. Hochsch., Diss.--Hannover, 2005.
    Source: Networked Digital Library of Theses and Dissertations
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  • 3
    Language: English
    Description: Background: In Parkinson’s disease (PD), alpha-synuclein accumulation in cutaneous autonomic pilomotor and sudomotor nerve fibers has been linked to autonomic nervous system disturbances even in the early stages of the disease. This study aims to assess the association between alpha-synuclein-mediated structural autonomic nerve fiber damage and function in PD, elucidate the role of neuropathy progression during the early disease stages, and test reproducibility and external validity of pilomotor function assessment using quantitative pilomotor axon-reflex test and sudomotor function via quantitative direct and indirect test of sudomotor function. Methods/design: A prospective controlled study will be conducted at four study sites in Europe and the USA. Fifty-two male and female patients with idiopathic PD (Hoehn and Yahr 1–2) and 52 age- and sex-matched healthy controls will be recruited. Axon-reflex-mediated pilomotor erection will be induced by iontophoresis of phenylephrine on the dorsal forearm. Silicone impressions of the response will be obtained, scanned, and quantified for pilomotor muscle impressions by number, impression size, and area of axon-reflex spread. Axon-reflex-mediated sweating following acetylcholine iontophoresis will be quantified for number and size of droplets and axon-reflex spread. Sympathetic skin responses, autonomic and motor symptoms will be evaluated. Tests will be performed at baseline, after 2 weeks, 1, 2, and 3 years. Skin biopsies will be obtained at baseline and after 3 years and will be analyzed for nerve fiber density and alpha-synuclein accumulation. Discussion: We anticipate that progression of autonomic nerve dysfunction assessed via pilomotor and sudomotor axon-reflex tests is related to progression of autonomic symptom severity and alpha-synuclein deposition. Potential applications of the techniques include interventional studies evaluating disease-modifying approaches and clinical assessment of autonomic dysfunction in patients with PD.
    Keywords: Info:Eu-Repo/Classification/Ddc/610 ; Ddc:610 ; Parkinson-Krankheit ; Autonom ; Axon-Reflex ; Diagnose ; Pilomotor ; Technische Universität Dresden ; Publikationsfonds ; Parkinson’s Disease ; Autonomic ; Axon-Reflex ; Diagnosis ; Pilomotor ; Technische Universität Dresden ; Publishing Fund
    Source: Networked Digital Library of Theses and Dissertations
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  • 4
    Language: Portuguese
    Description: Com base na Nova Economia Institucional, o foco desta pesquisa foi o de identificar os custos de transação existentes nos projetos de MDL (Mecanismo de Desenvolvimento Limpo) e investigar se eles são barreiras para o desenvolvimento do projeto, e se podem afetar a eficiência de projetos já implantados. Mais especificamente, foram analisadas as variáveis que afetam as diferenças entre as reduções de emissões estimadas nos projetos de MDL e as reduções realmente verificadas (Sucesso de Redução - SR), depois do projeto implantado e monitorado. A fim de cumprir esse objetivo, esta pesquisa contou com levantamento de dados secundários relativos aos projetos de MDL realizados em todo o mundo, e dados primários relativos aos projetos brasileiros de MDL. A análise das informações mostrou que os países mais relevantes em número de projetos são Índia, China, Brasil, mas este ranking se altera dependendo da variável analisada (por exemplo, volume de emissão reduzida ou estimada). Os setores mais relevantes em volume de redução são de HFC, N2O, mas este perfil se altera quando analisado o número de projetos, ficando em primeiro lugar biomassa, hidroelétrica e energia eólica. Em relação ao SR, a maior parte dos projetos não apresenta eficiência satisfatória. No entanto, em volume de reduções a maior parte dos projetos cumpre mais que 91% de SR. Os setores mundiais mais eficientes são N2O e HFC (Brasil N2O e troca de energia fóssil), e os setores de resíduos sólidos e agricultura (Brasil, agricultura e resíduos sólidos) são os menos eficientes. Finalmente, esta pesquisa conclui que custos de transação afetam o sucesso da redução de MDL, e os mais importantes são os custos ex-ante, resultantes de problemas de falhas de informação (como, por exemplo, problemas com as organizações que intermedeiam o processo dos MDLs) e problemas de mensuração (problemas relacionados com metodologias dos MDLs). Based on the New Institutional Economics, the focus of this research was to identify transaction costs in CDM projects (Clean Development Mechanism) and investigate if they can affect project efficiency, and also if they create project development barriers. More specifically, this research analyzed the variables that could affect the differences between CDM estimated emission reduction projects and actual reductions obtained (Reduction Success - RS) after the project has been implemented and monitored. To fulfill this goal, this research included a secondary global CDM projects data survey, and primary data survey related to Brazilian CDM projects. Data analysis showed that the most important countries in terms of number of projects are India, China, Brazil, but depending on the variable analyzed (for instance, emission reduction volume) this ranking could change. The most relevant sectors in emission reduction volume were HFCs, N2O, but this would change when we analyze number of projects, where biomass would come first, followed by hydroelectric and wind energy. When considering RS, most projects do not show satisfactory performance. However, in terms of emission reductions amount, most of the projects achieve more than 91% RS. The most efficient sectors in the world are HFC and N2O (in Brazil, N2O and fossil fuel), and the least efficient sectors are solid waste and agriculture (in Brazil, agriculture and solid waste). Finally, this research concludes that transaction costs affect the success of CDM reductions, and the most relevant are ex-ante costs, resulting from information problem gaps (these problems relate to parties involved in the CDM process) and measurement problems (CDM methodologies).
    Keywords: Carbon Credit ; Carbon Market ; Cdm ; Clean Development Mechanism ; Crédito De Carbono ; Custos De Transação ; Economia Institucional ; Institutional Economics ; Institutions ; Kyoto Protocol ; Mdl ; Mecanismo De Desenvolvimento Limpo ; Mercado De Carbono ; Nei ; New Institutional Economics ; Nova Economia Institucional ; Protocolo De Kyoto ; Ciência Ambiental
    Source: Networked Digital Library of Theses and Dissertations
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  • 5
    Dissertation
    Dissertation
    Universidade de São Paulo
    Language: Portuguese
    Description: As palavras no titulo desta tese \"Tipotretaletra\", se referem ao lugar da letra na pesquisa em poéticas na forma do trabalho escrito de cárater acadêmico. A treta por um lado é tensão; de outro são as estratégias necessárias para conviver a produção artística e produção acadêmica. O tipo pode ser uma maneira, um jeito ou o suporte físico para a impressão da letra, a treta como estratégia e método, a letra como letreiramento, a letra desenho e projeto; e o letramento, a letra como alfabetização, habilidade com o código desenvolvida por meio da educação. Todas as três palavras se relacionam de algum modo à pesquisa e ampliação de suportes é uma palavra em questão nesta tese a proposito dos vários caminhos e materialidades que compõem os trabalhos, desde a pintura, a performance, a tipografia, o objeto. The title ofthis thesis \"Tipotretaletra\" refer to the place ofthe word in a research ofvisual arts, about the form ofwritten word in a academic work. The \"treta\" as confusion as a tension; are strategies needed to live together the artistic production and academic production. The \"tipo\" can be like a typeface or a way to do anything. the \"treta\" as a strategy and method. The lettering, like a particular style ou the process ofwrinting, drawing or print words, the design ofthe letter; and the letter as literacy, like the ability to read and write acquired through education. All three words are related in some way to researches Mukambu which can be translated as support in Kikongo, refers from the stick with two people carry an object; Also can be a technology that use forks to support the ridge ofa house; support is a word in this thesis like several materiality that was made de art work, from painting, performance, typograpy, object.
    Keywords: Art/Word And Performance ; Arte E Palavra E Performance ; Contemporary Painting ; Desenho De Letra ; Letramento Racial ; Lettering ; Pintura Contemporânea ; Racial Literacy ; Poéticas Visuais
    Source: Networked Digital Library of Theses and Dissertations
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  • 6
    Language: English
    Description: Background: In Parkinson’s disease (PD), alpha-synuclein accumulation in cutaneous autonomic pilomotor and sudomotor nerve fibers has been linked to autonomic nervous system disturbances even in the early stages of the disease. This study aims to assess the association between alpha-synuclein-mediated structural autonomic nerve fiber damage and function in PD, elucidate the role of neuropathy progression during the early disease stages, and test reproducibility and external validity of pilomotor function assessment using quantitative pilomotor axon-reflex test and sudomotor function via quantitative direct and indirect test of sudomotor function. Methods/design: A prospective controlled study will be conducted at four study sites in Europe and the USA. Fifty-two male and female patients with idiopathic PD (Hoehn and Yahr 1–2) and 52 age- and sex-matched healthy controls will be recruited. Axon-reflex-mediated pilomotor erection will be induced by iontophoresis of phenylephrine on the dorsal forearm. Silicone impressions of the response will be obtained, scanned, and quantified for pilomotor muscle impressions by number, impression size, and area of axon-reflex spread. Axon-reflex-mediated sweating following acetylcholine iontophoresis will be quantified for number and size of droplets and axon-reflex spread. Sympathetic skin responses, autonomic and motor symptoms will be evaluated. Tests will be performed at baseline, after 2 weeks, 1, 2, and 3 years. Skin biopsies will be obtained at baseline and after 3 years and will be analyzed for nerve fiber density and alpha-synuclein accumulation. Discussion: We anticipate that progression of autonomic nerve dysfunction assessed via pilomotor and sudomotor axon-reflex tests is related to progression of autonomic symptom severity and alpha-synuclein deposition. Potential applications of the techniques include interventional studies evaluating disease-modifying approaches and clinical assessment of autonomic dysfunction in patients with PD.
    Keywords: Parkinson-Krankheit ; Autonom ; Axon-Reflex ; Diagnose ; Pilomotor ; Technische Universität Dresden ; Publikationsfonds ; Parkinson’s Disease ; Autonomic ; Axon-Reflex ; Diagnosis ; Pilomotor ; Technische Universität Dresden ; Publishing Fund ; Ddc:610 ; Rvk:Xa 10000
    Source: Networked Digital Library of Theses and Dissertations
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