Kooperativer Bibliotheksverbund

In: Nature, 1956, Vol.178(4533), p.594

ISSN: 0028-0836

E-ISSN: 1476-4687

DOI: 10.1038/178594a0

URL: View this record in Nature

In: Corporate Reputation Review, 2013, Vol.16(3), p.206

Description: While there are over 50 years of study on how CEO turnover influences corporate outcomes, there is a paucity of research on the impact of leadership changes on reputation. This study uses signaling theory to investigate the relationship between chief executive transitions and corporate reputation, as assessed by 2007 and 2008 Fortune ratings of 241 companies. On average, CEO successions improved reputations; however, companies with higher initial reputations were more likely to experience a decline in their subsequent reputations. These significant effects occurred over the short term and were not significant over the long term. The implications of these findings address how companies should manage CEO transition announcements and succession planning. [PUBLICATION ]

Keywords: United States–Us ; Studies ; Corporate Image ; Chief Executive Officers ; Succession Planning ; Reputation Management ; Social Responsibility ; Corporate Responsibility ; Statistical Analysis ; Human Resource Planning ; Chief Executive Officers ; Experimental/Theoretical ; United States ; Planning ; Public Relations;

ISSN: 1363-3589

E-ISSN: 14791889

DOI: 10.1057/crr.2013.12

URL: View this record in Nature

Language: English

In: npj Prim Care Resp Med, 2017, Vol.27(1), pp.4-4

Description: Chronic obstructive pulmonary disease prevalence rates are still high. However, the majority of subjects are not diagnosed. Strategies have to be implemented to overcome the problem of under-diagnosis. Questionnaires could be used to pre-select subjects for spirometry and thereby help reducing under-diagnosis. We report a brief, simple, self-administrable and validated chronic obstructive pulmonary disease questionnaire to increase the pre-test probability for chronic obstructive pulmonary disease diagnosis in subjects undergoing confirmatory spirometry. In 2005, we completed the Austrian Burden of Obstructive Lung Disease-study in 1258 subjects aged 〉40 years. Post-bronchodilator spirometry was performed, and non-reversible airflow limitation defined by FEV/FVC ratio below the lower limit of normal. Questions from the Salzburg chronic obstructive pulmonary disease screening-questionnaire were selected using a logistic regression model, and risk scores were based on regression-coefficients. A training sub-sample (n = 800) was used to create the score, and a test sub-sample (n = 458) was used to test it. In 2008, an external validation study was done, using the same protocol in 775 patients from primary care. The Salzburg chronic obstructive pulmonary disease screening questionnaire was composed of items related to “breathing problems”, “wheeze”, “cough”, “limitation of physical activity”, and “smoking”. At the 〉=2 points cut-off of the Salzburg chronic obstructive pulmonary disease screening questionnaire, sensitivity was 69.1% [95%CI: 56.6%; 79.5%], specificity 60.0% [95%CI: 54.9%; 64.9%], the positive predictive value 23.2% [95%CI: 17.7%; 29.7%] and the negative predictive value 91.8% [95%CI: 87.5%; 95.7%] to detect post bronchodilator airflow limitation. The external validation study in primary care confirmed these findings. The Salzburg chronic obstructive pulmonary disease screening questionnaire was derived from the highly standardized Burden of Obstructive Lung Disease study. This validated and easy to use questionnaire can help to increase the efficiency of chronic obstructive pulmonary disease case-finding.

Keywords: Article;

ISSN: 2055-1010

DOI: 10.1038/s41533-016-0005-7

In: Gene therapy, 2010, Vol.17(10), p.1244-1252

Description: One of the major hurdles for the development of gene therapy for Fanconi anemia (FA) is the increased sensitivity of FA stem cells to free radical-induced DNA damage during ex vivo culture and manipulation. To minimize this damage, we have developed a brief transduction procedure for lentivirus vector-mediated transduction of hematopoietic progenitor cells from patients with Fanconi anemia complementation group A ( FANCA ). The lentiviral vector FancA-sW contains the phosphoglycerate kinase promoter, the FANCA cDNA, and a synthetic, safety-modified woodchuck post transcriptional regulatory element (sW). Bone marrow mononuclear cells or purified CD34 + cells from patients with FANCA were transduced in an overnight culture on recombinant fibronectin peptide CH-296, in low (5%) oxygen, with the reducing agent, N-acetyl-L-cysteine (NAC), and a combination of growth factors, granulocyte colony-stimulating factor (G-CSF), Flt3 ligand, stem cell factor (SCF), and thrombopoietin. Transduced cells plated in methylcellulose in hypoxia with NAC exhibited increased colony formation compared to 21% oxygen without NAC (P 〈 0.03), demonstrated increased resistance to mitomycin C compared to green fluorescent protein (GFP )-transduced controls (P 〈 0.007), and increased survival. Thus, combining short transduction and reducing oxidative stress may enhance the viability and engraftment of gene-corrected cells in patients with FANCA .

Keywords: Article ; Gene Therapy ; Mitomycin C ; Reducing Agent ; Hypoxia

ISSN: 0969-7128

E-ISSN: 1476-5462

DOI: 10.1038/gt.2010.62

In: EMBO Journal, 08 February 2006, Vol.25(3), pp.653-653

Description: Correction to: The EMBO Journal (2005) 24, 3624–3634. doi:10.1038/sj.emboj.7600824

Keywords: Biology ; Chemistry;

ISSN: 0261-4189

E-ISSN: 1460-2075

DOI: 10.1038/sj.emboj.7600956

In: EMBO Journal, 19 October 2005, Vol.24(20), pp.3624-3634

Description: The amyloid precursor protein (APP) plays a central role in Alzheimer's disease, but its physiological function and that of its mammalian paralogs, the amyloid precursor‐like proteins 1 and 2 (APLPs), is still poorly understood. APP has been proposed to form dimers, a process that could promote cell adhesion via ‐dimerization. We investigated the dimerization and cell adhesion properties of APP/APLPs and provide evidence that all three paralogs are capable of forming homo‐ and heterocomplexes. Moreover, we show that ‐interaction of APP family proteins promotes cell–cell adhesion in a homo‐ and heterotypic fashion and that endogenous APLP2 is required for cell–cell adhesion in mouse embryonic fibroblasts. We further demonstrate interaction of all the three APP family members in mouse brain, genetic interdependence, and molecular interaction of APP and APLPs in synaptically enriched membrane compartments. Together, our results provide evidence that homo‐ and heterocomplexes of APP/APLPs promote ‐cellular adhesion .

Keywords: Alzheimer'S Disease ; App ; Cell Adhesion ; Dimerization

ISSN: 0261-4189

E-ISSN: 1460-2075

DOI: 10.1038/sj.emboj.7600824