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Berlin Brandenburg

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  • JSTOR Current Journals  (4)
  • Oxford University Press (CrossRef)  (4)
  • 1
    Language: English
    In: The Journal of Infectious Diseases, 1 February 1990, Vol.161(2), pp.336-339
    Description: The development of vaccines to prevent Neisseria infections has been impeded by antigenic diversity of most Neisseria surface components. The lipid-modified azurin (Laz), one of two distinct surface proteins recognized by the H.8 monoclonal antibody, is present in all pathogenic Neisseria. The mature protein has two domains; one contains an H.8 epitope and the other has extensive homology to azurins, a class of bacterial copper-binding proteins. The cellular location of Laz and the serum immune response to Laz were examined in patients with disseminated Neisseria infections. The data demonstrated that Laz is probably contained in the Neisseria outer membrane, although unlike most outer membrane proteins it is Sarkosyl soluble. By probing recombinant bacteriophages encoding the H.8 and azurin domains of Laz, results showed that whereas the H.8 epitope is immunogenic in patients with disseminated Neisseria infections, the azurin domain of Laz plays little role in eliciting an antibody response in these patients.
    Keywords: Biological sciences -- Biology -- Microbiology -- Epitopes ; Physical sciences -- Chemistry -- Chemical compounds -- Polyclonal antibodies ; Health sciences -- Medical conditions -- Infections -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Physical sciences -- Astronomy -- Astronomical cosmology -- Monoclonal antibodies ; Physical sciences -- Chemistry -- Chemical compounds -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies
    ISSN: 00221899
    E-ISSN: 15376613
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  • 2
    Language: English
    In: The Journal of Infectious Diseases, 1 July 1986, Vol.154(1), pp.100-109
    Description: Eighty-six nasopharyngeal isolates of Haemophilus influenzae were prospectively obtained from three children who attended a day care center from infancy until early childhood (five to seven years). A majority of the strains were nontypable. We analyzed strains by comparing their biotypes and by performing electrophoresis of outer membrane proteins on polyacrylamide gels. Profiles of outer membrane proteins were very heterogeneous and could not be used as the basis for the development of a subtyping scheme. The children characteristically carried a nasopharyngeal strain defined by a unique outer membrane pattern for a period of months, lost it, and then acquired a new strain. We probed the outer membrane proteins of a child's strains by the western blot technique with serum obtained serially from the child. Isolates whose outer membrane proteins appeared identical on stained gels generally had similar antigenic bands on western blots but were occasionally immunologically distinct. Serum immunoglobulins of the IgG class that reacted with the outer membrane proteins did not appear to change greatly over time or to play a role in preventing or terminating colonization. We conclude that nasopharyngeal colonization in children by nontypable H. influenzae is a dynamic process and that factors that cause loss and acquisition of strains remain to be determined
    Keywords: Biological sciences -- Biology -- Microbiology ; Health sciences -- Medical sciences -- Immunology ; Applied sciences -- Materials science -- Materials ; Health sciences -- Medical sciences -- Immunology ; Behavioral sciences -- Sociology -- Human societies ; Health sciences -- Medical conditions -- Infections ; Health sciences -- Health and wellness -- Public health ; Health sciences -- Medical conditions -- Infections ; Physical sciences -- Chemistry -- Chemical compounds ; Health sciences -- Medical conditions -- Diseases
    ISSN: 00221899
    E-ISSN: 15376613
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  • 3
    Language: English
    In: The Journal of Infectious Diseases, 1 May 1994, Vol.169(5), pp.1146-1150
    Description: Four subjects were experimentally infected with Haemophilus ducreyi. Lesions developed only at sites where live bacteria were inoculated on abraded skin. No subject developed fever, lymphadenopathy, or disseminated infection during a 3-day observation period. Two subjects who were rechallenged 2 months after initial infection also developed lesions. The amount of H. ducreyi recovered from 10 of 12 biopsies that were semiquantitatively cultured varied widely. Similar histologic features were present in initial and second infections. The epidermis contained pustules; the dermis contained an infiltrate of T cells and macrophages and reactive endothelial cells. Keratinocytes and T cells expressed HLA-DR, consistent with a delayed-type hypersensitivity response. The subjects did not mount humoral responses to bacterial proteins and to lipooligosaccharides after primary and secondary challenges. Thus, human experimental infection with H. ducreyi is well tolerated and safe. Recruitment of T cells and macrophages into chancroid lesions may partially explain the association between chancroid and human immunodeficiency virus transmission.
    Keywords: Biological sciences -- Biology -- Physiology -- Heterophils ; Biological sciences -- Biology -- Physiology -- Heterophils ; Health sciences -- Medical conditions -- Infections -- Heterophils ; Biological sciences -- Biology -- Physiology -- Heterophils ; Biological sciences -- Biochemistry -- Biomolecules -- Heterophils ; Biological sciences -- Biochemistry -- Biomolecules -- Heterophils ; Health sciences -- Medical conditions -- Diseases -- Heterophils ; Health sciences -- Medical conditions -- Infections -- Heterophils ; Biological sciences -- Biochemistry -- Biomolecules -- Heterophils ; Health sciences -- Medical conditions -- Diseases -- Heterophils
    ISSN: 00221899
    E-ISSN: 15376613
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  • 4
    Language: English
    In: The Journal of Infectious Diseases, 1 February 1996, Vol.173(2), pp.394-402
    Description: Human subjects were experimentally infected with Haemophilus ducreyi for up to 2 weeks. Bacterial suspensions were delivered into the epidermis and dermis through puncture wounds made by an allergy-testing device. Subjects developed papular lesions that evolved into pustules resembling natural disease. Some papular lesions resolved spontaneously, indicating that host responses may clear infection. Bacteria were shed intermittently from lesions, suggesting that H. ducreyi may be transmissible before ulceration. Host responses to infection consisted primarily of cutaneous infiltrate of polymorphonuclear leukocytes, Langerhans cells, macrophages, and CD4 T cells of α/β lineage. Expression of HLA-DR by keratinocytes was associated with the presence of interferon-γ mRNA in the skin. There was little evidence for humoral or peripheral blood mononuclear cell responses to bacterial antigens. The cutaneous infiltrate of CD4 cells and macrophages provides a mechanism that facilitates transmission of human immunodeficiency virus by H. ducreyi.
    Keywords: Health sciences -- Medical conditions -- Physical trauma -- Lymphocytes ; Biological sciences -- Biology -- Anatomy -- Lymphocytes ; Health sciences -- Medical sciences -- Immunology -- Lymphocytes ; Health sciences -- Medical conditions -- Infections -- Lymphocytes ; Biological sciences -- Biology -- Physiology -- Lymphocytes ; Biological sciences -- Biology -- Microbiology -- Lymphocytes ; Health sciences -- Medical conditions -- Infections -- Lymphocytes ; Health sciences -- Medical sciences -- Immunology -- Lymphocytes ; Health sciences -- Medical diagnosis -- Diagnostic methods -- Lymphocytes ; Health sciences -- Medical sciences -- Pharmacology -- Lymphocytes
    ISSN: 00221899
    E-ISSN: 15376613
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