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  • PMC (PubMed Central)  (17)
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  • 1
    In: Journal of Surgical Case Reports, 2010, Vol. 2010(10), pp.7-7
    Description: Abdominal tuberculosis (TB) is the sixth commonest extra-pulmonary TB form after lymphatic, genitourinary, bone and joint, miliary and meningeal tuberculosis. Perforation is a serious and uncommon complication of abdominal tuberculosis which can occur even during the treatment. A 30-year-old man was admitted with a three-day history of abdominal pain who had emergency surgery for multiple perforations of the distal ileum.
    Keywords: Colorectal Surgery ; 040;
    E-ISSN: 2042-8812
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  • 2
    Language: English
    In: BMC Bioinformatics, 01 December 2017, Vol.18(S14), pp.93-102
    Description: Abstract Background Blockage of some ion channels and in particular, the hERG (human Ether-a’-go-go-Related Gene) cardiac potassium channel delays cardiac repolarization and can induce arrhythmia. In some cases it leads to a potentially life-threatening arrhythmia known as Torsade de Pointes (TdP). Therefore recognizing drugs with TdP risk is essential. Candidate drugs that are determined not to cause cardiac ion channel blockage are more likely to pass successfully through clinical phases II and III trials (and preclinical work) and not be withdrawn even later from the marketplace due to cardiotoxic effects. The objective of the present study is to develop an SAR (Structure-Activity Relationship) model that can be used as an early screen for torsadogenic (causing TdP arrhythmias) potential in drug candidates. The method is performed using descriptors comprised of atomic NMR chemical shifts (13C and 15N NMR) and corresponding interatomic distances which are combined into a 3D abstract space matrix. The method is called 3D-SDAR (3-dimensional spectral data-activity relationship) and can be interrogated to identify molecular features responsible for the activity, which can in turn yield simplified hERG toxicophores. A dataset of 55 hERG potassium channel inhibitors collected from Kramer et al. consisting of 32 drugs with TdP risk and 23 with no TdP risk was used for training the 3D-SDAR model. Results An artificial neural network (ANN) with multilayer perceptron was used to define collinearities among the independent 3D-SDAR features. A composite model from 200 random iterations with 25% of the molecules in each case yielded the following figures of merit: training, 99.2%; internal test sets, 66.7%; external (blind validation) test set, 68.4%. In the external test set, 70.3% of positive TdP drugs were correctly predicted. Moreover, toxicophores were generated from TdP drugs. Conclusion A 3D-SDAR was successfully used to build a predictive model for drug-induced torsadogenic and non-torsadogenic drugs based on 55 compounds. The model was tested in 38 external drugs.
    Keywords: Artificial Neural Network ; Cardiac Arrhythmia ; Cardiotoxicity ; Herg ; Ion Channels ; Multilayer Perceptron ; Biology
    E-ISSN: 1471-2105
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  • 3
    Language: English
    In: Bioengineering (Basel, Switzerland), 20 April 2018, Vol.5(2)
    Description: A dynamic musculoskeletal model of the elbow joint in which muscle, ligament, and articular surface contact forces are predicted concurrently would be an ideal tool for patient-specific preoperative planning, computer-aided surgery, and rehabilitation. Existing musculoskeletal elbow joint models have limited clinical applicability because of idealizing the elbow as a mechanical hinge joint or ignoring important soft tissue (e.g., cartilage) contributions. The purpose of this study was to develop a subject-specific anatomically correct musculoskeletal elbow joint model and evaluate it based on experimental kinematics and muscle electromyography measurements. The model included three-dimensional bone geometries, a joint constrained by multiple ligament bundles, deformable contacts, and the natural oblique wrapping of ligaments. The musculoskeletal model predicted the bone kinematics reasonably accurately in three different velocity conditions. The model predicted timing and number of muscle excitations, and the normalized muscle forces were also in agreement with the experiment. The model was able to predict important in vivo parameters that are not possible to measure experimentally, such as muscle and ligament forces, and cartilage contact pressure. In addition, the developed musculoskeletal model was computationally efficient for body-level dynamic simulation. The maximum computation time was less than 30 min for our 35 s simulation. As a predictive clinical tool, the potential medical applications for this model and modeling approach are significant.
    Keywords: Cartilage ; Contact Mechanics ; Elbow Joint ; Kinematics ; Ligaments ; Musculoskeletal Model ; Upper Extremity
    ISSN: 2306-5354
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  • 4
    In: Advanced Biomedical Research, 2018, Vol.7(1), p.43-43
    Description: Background: Marine organisms produce a variety of compounds with pharmacological activities including anticancer effects. This study attempt to find cytotoxicity of hexane (HEX), dichloromethane (DCM), and butanol (BUTOH) partitions of Sargassum angustifolium. Materials and Methods: S. angustifolium was collected from Bushehr, a Southwest coastline of Persian Gulf. The plant was extracted by maceration with methanol-ethyl acetate. The extract was evaporated under vacuum and partitioned by Kupchan method to yield HEX, DCM, and BUTOH partitions. The cytotoxic activity of the extract (150, 450, and 900 μg/ml) was investigated against MCF-7 (breast cancer), HeLa (cervical cancer), and human umbilical vein endothelial cells cell lines by mitochondrial tetrazolium test assay after 72 h. Results: The cell survivals of HeLa and MCF-7 cell were decreased by increasing the concentration of extracts from 150 μg/ml to 900 μg/ml. The median growth inhibitory concentration value of HEX partition was 71 and 77 μg/ml against HeLa and MCF-7, dichloromethane partition was 36 and 88 μg/ml against HeLa and MCF-7, respectively. BUTOH partition was 25 μg/ml against MCF-7. Conclusion: This study reveals that different partitions of S. angustifolium have cytotoxic activity against cancer cell lines.
    Keywords: Cancer; cytotoxic; Persian Gulf; Sargassum
    ISSN: 2277-9175
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  • 5
    Language: English
    In: Sensors, 01 August 2009, Vol.9(9), pp.6764-6794
    Description: Existing 3-dimensional acoustic target tracking methods that use wired/wireless networked sensor nodes to track targets based on four sensing coverage do not always compute the feasible spatio-temporal information of target objects. To investigate this discrepancy in a formal setting, we propose a geometric model of the target tracking problem alongside its equivalent geometric dual model that is easier to solve. We then study and prove some properties of dual model by exploiting its relationship with algebra. Based on these properties, we propose a four coverage axis line method based on four sensing coverage and prove that four sensing coverage always yields two dual correct answers; usually one of them is infeasible. By showing that the feasible answer can be only sometimes identified by using a simple time test method such as the one proposed by ourselves, we prove that four sensing coverage fails to always yield the feasible spatiotemporal information of a target object. We further prove that five sensing coverage always gives the feasible position of a target object under certain conditions that are discussed in this paper. We propose three extensions to four coverage axis line method, namely, five coverage extent point method, five coverage extended axis lines method, and five coverage redundant axis lines method. Computation and time complexities of all four proposed methods are equal in the worst cases as well as on average being equal to Θ(1) each. Proposed methods and proved facts about capabilities of sensing coverage degree in this paper can be used in all other methods of acoustic target tracking like Bayesian filtering methods.
    Keywords: Wireless Sensor Networks ; 3-Dimensional Acoustic Target Tracking ; Geometry and Algebra ; Sensing Coverage ; Square Error ; Engineering
    ISSN: 1424-8220
    E-ISSN: 1424-8220
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  • 6
    Language: English
    In: Sensors, 01 May 2009, Vol.9(5), pp.3405-3436
    Description: Distributed acoustic target tracking is an important application area of wireless sensor networks. In this paper we use algebraic geometry to formally model 2-dimensional acoustic target tracking and then prove its best degree of required sensing coverage. We present the necessary conditions for three sensing coverage to accurately compute the spatio-temporal information of a target object. Simulations show that 3-coverage accurately locates a target object only in 53% of cases. Using 4-coverage, we present two different methods that yield correct answers in almost all cases and have time and memory usage complexity of Θ(1). Analytic 4-coverage tracking is our first proposed method that solves a simultaneous equation system using the sensing information of four sensor nodes. Redundant answer fusion is our second proposed method that solves at least two sets of simultaneous equations of target tracking using the sensing information of two different sets of three sensor nodes, and fusing the results using a new customized formal majority voter. We prove that 4-coverage guarantees accurate 2-dimensional acoustic target tracking under ideal conditions.
    Keywords: Wireless Sensor Networks ; Quality of Service ; Target Tracking ; Geometric Algebra ; Sensing Coverage ; Accuracy ; Engineering
    ISSN: 1424-8220
    E-ISSN: 1424-8220
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  • 7
    Language: English
    In: Marine Drugs, 01 February 2019, Vol.17(2), p.86
    Description: The saponin composition of a specimen of black sea cucumber, Holothuria atra collected in the Persian Gulf was studied by a combined approach including LC-MS/MS, Molecular Networking, pure compound isolation, and NMR spectroscopy. The saponin composition of Holothuria atra turned out to be more complex than previously reported. The most abundant saponins in the extract (1⁻4) were isolated and characterized by 1D- and 2D-NMR experiments. Compound 1 was identified as a new triterpene glycoside saponin, holothurin A5. The side chain of the new saponin 1, unprecedented among triterpene glycosides, is characterized by an electrophilic enone function, which can undergo slow water or methanol addition under neutral conditions. The cytotoxic activity of compounds 1⁻4, evaluated on the human cervix carcinoma HeLa cell line, was remarkable, with IC50 values ranging from 1.2 to 2.5 µg/mL.
    Keywords: Sea Cucumbers ; Holothurians ; Saponins ; Triterpene Glycosides ; LC-MS/MS ; Molecular Networking ; Cytotoxic Activity ; Pharmacy, Therapeutics, & Pharmacology
    E-ISSN: 1660-3397
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  • 8
    Language: English
    In: Journal of Cardiovascular and Thoracic Research, 01 March 2015, Vol.7(1), pp.24-27
    Description: Introduction: Congestive heart failure (CHF) is a common disease and its prevalence is increasingin industrialized countries. NT-proBNP measurement is an established diagnostic test fordiagnosis of CHF in patients who present to emergency room with acute dyspnea. The primaryobject of this study was to determine the relationship between levels of brain natriuretic peptideprecursor and severity of lung function impairment in patients with chronic CHF.Methods: This cross-sectional and analytical study that performed in Tuberculosis andLung Disease Research Center of Tabriz University of Medical Sciences on 95 patients withchronic heart failure, and relation between NT-proBNP levels and pulmonary functionparameters were examined.Results: Sixty-four patients were male and 31 were female. The average age of male and femaleswas 62.90 ± 11.54 and 61.61 ± 11.98 years, respectively. A significant inverse linear correlationwas found between NT-proBNP and FEV1 (P〈0.001, r = -0.367), FVC (P〈0.001, r = -0.444),TLC (P=0.022, r = -0.238), maximal midexpiratory flow (MMEF) (P=0.047, r = -0.207) andleft ventricular ejection fraction (LVEF) (P〈0.001, r = -0.461). A significant positive linearcorrelation was found between NT-proBNP and FEV1/FVC (P =0.013, r = 0.257), RV/TLC (P =0.003, r=0.303) and 5 Hz Raw (r = 0.231, P = 0.024).Conclusion: This study showed that, both restrictive and obstructive ventilator impairments canoccur in chronic CHF and as NT-proBNP increases appropriate to hemodynamic deterioration,pulmonary dysfunction increases.
    Keywords: Congestive Heart Failure ; NT-Probnp ; Respiratory Function Tests ; Medicine
    ISSN: 2008-5117
    E-ISSN: 2008-6830
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  • 9
    Language: English
    Description: Macrophage migration inhibitory factor (MIF) has an important role in controlling infection. The aim of this study was to evaluate the possible association between MIF -173 G/C functional polymorphism and pulmonary tuberculosis (PTB) in an Iranian population from Zahedan Southeast Iran. This case-control study was done on 161 PTB and 142 healthy subjects. Genomic DNA was extracted from all participants by salting out method. The MIF -173 G/C variant was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The finding showed that the MIF -173 G/C polymorphism increased the risk of PTB in codominant (OR=1.76, 95 % CI=1.05-2.95, p=0.038, GC vs GG) and dominant (OR=1.78, 95 % CI=1.09-2.91, p=0.027, GC+CC vs GG) tested inheritance models. Furthermore, the minor allele frequency (MAF) increased the risk of PTB in comparison with G allele (OR=1.63, 95 % CI=1.07-2.48, p=0.028). In conclusion, the present study provides evidence that -173 G/C polymorphism may increase the risk of PTB....
    Keywords: Tuberculosis ; Macrophage Migration Inhibitory Factor ; Mif ; Polymorphism
    ISSN: 16112156
    E-ISSN: 16112156
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  • 10
    Language: English
    In: Open access Macedonian journal of medical sciences, 25 November 2018, Vol.6(11), pp.2193-2197
    Description: This study was conducted to investigate the effect of applying Gates-Glidden (GG) drill by pre-clinical dental students on root canal treatment quality. A total of 56 first molars consisting of 168 canals were selected in this study. For this purpose, 56 students who had been formerly trained by two methods of root canal preparation were randomly divided into two groups (n = 28). Group 1: the step-down method by GG and Group 2: step-back technique without GG. The prepared teeth were filled with gutta-percha/ZOE sealer using lateral condensation. Periapical radiographs were taken before and the following treatment to survey occurrence of preparation errors and CBCT images to determine residual dentine at furcation region. The findings showed that among 10 error types in specimens prepared by students, the occurrence of underfilling, overfilling, inappropriate, ledge formation, and single cone was more common without GG. There were no significant differences in residual dentine amount at furcation region between preparation with and without using GG (P 〉 0.05). Using GG for root canal preparation by dental students resulted in low errors and not an increased dentine removal risk.
    Keywords: Cone Beam Computed Tomography ; Dental Students ; Gates-Glidden ; Iatrogenic Errors ; Root Canal Treatment
    ISSN: 1857-9655
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