Kooperativer Bibliotheksverbund

Berlin Brandenburg

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  • 1
    Language: English
    In: Neuropsychobiology, 1983, Vol.9(1), pp.9-12
    Description: Platelet recovery and activity of platelet monoamine oxidase (MAO) and plasma amine oxidase (PAO) were determined using different centrifugation procedures (125 g for 15 min vs. 600 g for 2.5 min) and anticoagulants. With either centrifugation procedure, the use of ethylenediaminetetraacetate (EDTA) as anticoagulant resulted in higher platelet yields and MAO activity compared to acid-citrate-dextrose (ACD). However, PAO activity was lower with EDTA as anticoagulant than with ACD. There was a trend toward higher platelet yields and higher activity levels of MAO and PAO with the 125 g centrifugation method than with the 600 g technique regardless of the anticoagulant used. The implications for MAO studies in psychiatric research were discussed.
    Keywords: Biological Psychiatry ; Platelet Monoamine Oxidase ; Plasma Amine Oxidase ; Centrifugation Procedures ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0302-282X
    E-ISSN: 1423-0224
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  • 2
    Language: English
    In: Respiration, July 2016, Vol.91(6), pp.503-509
    Description: Background: Patients with chronic thromboembolic pulmonary disease (CTED) have persistent pulmonary vascular obstruction and exercise intolerance without pulmonary hypertension at rest and may benefit from pulmonary endarterectomy. However, up to now, CTED has been poorly characterized. Objectives: This study aimed to analyze the exercise capacity and limiting factors in CTED. Methods: We compared right heart catheterization and cardiopulmonary exercise test results of patients with CTED [mean pulmonary artery pressure (mPAP) at rest 〈25 mm Hg, n = 10], chronic thromboembolic pulmonary hypertension (CTEPH, n = 31) and a control group (n = 41) presenting with dyspnea but normal pulmonary vascular imaging and excluded pulmonary hypertension. Results: Subjects with CTED show a reduced oxygen uptake [median 76/interquartile range (IQR) 22% pred.] and work rate (median 76/IQR 21 W). The work rate was significantly lower compared to control subjects (p = 0.04) but not significantly different from CTEPH patients (p = 0.66). Oxygen pulse and breathing reserve were normal. CTED subjects showed decreased end-tidal CO2 at anaerobic threshold (28.4/4.3 mm Hg), an elevated VE/VCO2 slope (42.5/23.5), breathing equivalents (EQO2 32.0/8.7, EQCO2 39.5/8.8), alveolar-capillary oxygen gradient (34.7/15.5 mm Hg) and capillary end-tidal carbon dioxide gradient (8.8/5.7 mm Hg) compared to control subjects (p 〈 0.001). The degree of limitation was similar to that in CTEPH. Conclusions: Despite an mPAP of 〈25 mm Hg, subjects with CTED show objective functional impairment and similar limitations to patients with CTEPH. Functional limitation is characterized by gas exchange disturbance and ineffective ventilation.
    Keywords: Clinical Investigations ; Chronic Thromboembolic Pulmonary Disease ; Chronic Thromboembolic Pulmonary Hypertension ; Mean Pulmonary Artery Pressure ; Medicine
    ISSN: 0025-7931
    E-ISSN: 1423-0356
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  • 3
    Language: English
    In: Neuropsychobiology, 1982, Vol.8(6), pp.312-314
    Description: Plasma dopamine-beta-hydroxylase (DBH) activity was determined in 8 chronic schizophrenic patients following neuroleptic treatment for 2 months. Enzyme activity was decreased by 13.7 ± 3.4% (mean ± SD). The difference from pre-drug levels was not statistically significant. The reduction in DBH activity stabilized after the 1 st month of treatment and was unrelated to neuroleptic drug load.
    Keywords: Paper ; Dopamine-Beta-Hydroxylase ; Neuroleptics ; Schizophrenia ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0302-282X
    E-ISSN: 1423-0224
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  • 4
    Language: English
    In: Neuropsychobiology, 1984, Vol.11(3), pp.178-180
    Description: Age and sex effects on 3H-imipramine platelet binding sites were determined in 58 normal subjects (27 males, 31 females). The correlation of age with either the maximal imipramine binding (Bmax) or the dissociation constant (Kd) was statistically nonsignificant in both males and females. Males did not differ from females in Bmax and Kd values. The implications for psychiatric research were discussed.
    Keywords: Biological Psychiatry ; 3h-Imipramine Platelet Binding Sites ; Age ; Sex ; Psychiatric Research ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0302-282X
    E-ISSN: 1423-0224
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  • 5
    Language: English
    In: Neuropsychobiology, 1984, Vol.12(4), pp.206-208
    Description: The occurrence of stressful life events in relation to illness onset and family history of schizophrenia was assessed in 52 chronic schizophrenic patients. Severe or extreme premorbid stress was present in 15.4% of the patients. ‘Low stress’ patients were indistinguishable from ‘high stress’ patients with respect to the familial rate of schizophrenia and other ‘spectrum’ disorders.
    Keywords: Biological Psychiatry ; Family History ; Life Event ; Schizophrenia ; Onset ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0302-282X
    E-ISSN: 1423-0224
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  • 6
    Language: English
    In: Neuropsychobiology, 1988, Vol.19(1), pp.9-11
    Description: Using a cross-sectional design, we examined the diurnal and circannual variation in platelet 3H-imipramine binding in 33 patients with bipolar affective disorder, 34 patients with unipolar affective disorder and 58 normal controls. There was no evidence for statistically significant diurnal or circannual variation in the binding parameters in any of the diagnostic categories.
    Keywords: Biological Psychiatry ; Platelet 3h-Imipramine Binding ; Affective Disorder ; Diurnal and Seasonal Variation ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0302-282X
    E-ISSN: 1423-0224
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  • 7
    Language: English
    In: Neuropsychobiology, 1987, Vol.17(4), pp.182-186
    Description: We studied platelet 3H-imipramine binding and family history of affective illness in 26 patients with bipolar affective disorder and 24 patients with unipolar affective disorder. The density of platelet 3H-imipramine binding sites (Bmax) was significantly lower in bipolar patients with family history of affective illness than in healthy controls; however, there was a considerable overlap in Bmax values between the familial cases and the normal controls. A similar trend was observed in familial cases of unipolar disorder but the differences fell short of statistical significance. The nonfamilial cases of affective disorder did not differ from the healthy controls. The possible role of reduced platelet 3H-imipramine binding as a genetic vulnerability ‘marker’ in affective disorder was discussed.
    Keywords: Biological Psychiatry ; Family History ; Platelet 3h-Imipramine Binding ; Affective Disorder ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0302-282X
    E-ISSN: 1423-0224
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  • 8
    Language: English
    In: Urologia Internationalis, 1987, Vol.42(3), pp.165-169
    Description: The induction of transitional cell bladder tumors following portacaval shunt (PCA) in rats was investigated. Thirty-five (29 males; 6 females) out of 86 animals developed a carcinoma. The highest incidence of tumors (73%) was seen in control animals without a PCA but with implantation of a bladder stone. PCA rats had an induction rate of 34% and a spontaneous bladder tumor was seen in 2/13 sham-operated controls. All rats with a bladder tumor also had urolithiasis; 34 rats had bladder stones in 1 rat had kidney stones. The induction rate in males was 29/52, 55.7% compared to 6/34, 17.6% in females. All tumors were transitional cell carcinomas and were graded G0-GIII [1(G0); 24 (GI); 1 (GI-II); 9 (GII)] accompanied in 20 cases by squamous cell metaplasia. Chronic irritation by stones and infection are the most likely causes of tumor development; however, other mechanisms such as excretion of carcinogens or tumor promoters cannot be completely excluded. The sex difference in stone formation – and tumor induction – are subject to further investigations.
    Keywords: Original Paper ; Portacaval Shunt ; Bladder Carcinoma ; Carcinogenesis ; Chronic Irritation ; Medicine
    ISSN: 0042-1138
    E-ISSN: 1423-0399
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