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  • Sage Publications (CrossRef)  (27)
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  • 1
    Language: English
    In: Natural Product Communications, August 2017, Vol.12(8)
    Description: Spirostanol saponins, 1–6 and 18–19 (normal-type F ring), isolated from Solanum torvum and S. macaonense showed anti-metastatic and anti-inflammatory effects, especially 2 and 18 could be chosen as the promising candidates against inflammation-associated tumors.
    Keywords: Solanum Torvum ; Solanum Macaonense ; Solanaceae ; Steroidal Glycoside ; Cytotoxicity ; Anti-Inflammation ; Chemistry
    ISSN: 1934-578X
    E-ISSN: 1555-9475
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  • 2
    Language: English
    In: Natural product communications, January 2014, Vol.9(1), pp.83-4
    Description: Three phenanthrenes (1-3), four indole alkaloids (4-7) and one steroid (8) were isolated from the leaves of Calanthe arisanensis for the first time. In the antiplatelet aggregation assay, phenanthrenes 1 and 2 showed potential antiplatelet activity. We have reported and discussed here the antiplatelet aggregation properties of the eleven naturally-occurring phenanthrenes (1-2 and 9-17) isolated from the underground part of the plant and eighteen chemically synthesized phenanthrenes (18-35). Overall, our data demonstrated that 1,4-phenanthrenequinones 20, 21 and 22 (collagen, IC50 0.2, 0.2, 0.1 microg/mL; thrombin, IC50 0.8, 1.0, 1.1 microg/mL, respectively) could be promising lead candidates for further cardiovascular disease studies.
    Keywords: Orchidaceae -- Chemistry ; Phenanthrenes -- Isolation & Purification ; Platelet Aggregation Inhibitors -- Isolation & Purification
    ISSN: 1934-578X
    E-ISSN: 15559475
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  • 3
    Language: English
    In: Natural product communications, August 2013, Vol.8(8), pp.1037-40
    Description: Three natural clovane-related sesquiterpenoids, 2beta-acetoxyclovan-9alpha-ol (1), 9alpha-acetoxyclovan-2beta-ol (2) and clovan-2beta,9beta-diol (3), were isolated from the gorgonian coral Rumphella antipathies. The structures of clovanes 1-3 were elucidated by spectroscopic methods and by comparison of the spectral data with those of known clovane analogues. This is the first time that clovanes 1-3 have been isolated from a natural source. Clovanes 1 and 2 displayed inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
    Keywords: Anthozoa -- Chemistry ; Anti-Inflammatory Agents, Non-Steroidal -- Isolation & Purification ; Sesquiterpenes -- Isolation & Purification
    ISSN: 1934-578X
    E-ISSN: 15559475
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  • 4
    Language: English
    In: Natural product communications, June 2015, Vol.10(6), pp.835-8
    Description: Two new natural caryophyllane-type sesquiterpenoids, 1 and 2, were isolated from the gorgonian coral Rumphella antipathies. Standard spectroscopic techniques were used to determine the structures of caryophyllanes 1 and 2.
    Keywords: Anthozoa -- Chemistry ; Polysaccharides -- Chemistry ; Sesquiterpenes -- Chemistry
    ISSN: 1934-578X
    E-ISSN: 15559475
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  • 5
    Language: English
    In: Natural product communications, February 2015, Vol.10(2), pp.345-8
    Description: One new cerebroside, macaocerebroside A (1), and 15 known compounds (2-16) were isolated from Solanum macaonense for the first time. In an antineutrophilic inflammatory assay, four caffeic acid derivatives (2-5) were active against superoxide anion generation with IC50 values of 3.3-4.8 μM; especially, 3 inhibited elastase release with an IC50 value of 4.0 μM. Additionally, kaempferol (8) also showed inhibition against elastase release with an IC50 value of 4.0 μM. In a cytotoxic assay, rutin (14) had selective moderate cytotoxicity toward human lung (A549), bladder (NTUB1), and prostate (DU145) cancer cell lines with IC50 values of 34.6, 41.3, and 31.8 μM, respectively.
    Keywords: Anti-Inflammatory Agents, Non-Steroidal -- Chemistry ; Antineoplastic Agents, Phytogenic -- Chemistry ; Solanum -- Chemistry
    ISSN: 1934-578X
    E-ISSN: 15559475
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  • 6
    Language: English
    In: Natural product communications, December 2012, Vol.7(12), pp.1623-6
    Description: Through bioassay-guided fractionation, thirteen compounds (1-13) were isolated from the dry root of Semiaquilegia adoxoides, known as Tiankuizi in traditional Chinese medicine (TCM). Among these, four benzoic acid derivatives (1, 2, 4, 5), one 4,6-dimethoxy-5-methyl-2H-pyran-2-one (10) and one 1,2,3-propanetriol (13) were found for the first time in S. adoxoides. This is the first record of compound 10 from a natural source. 4-Hydroxybenzoic acid (1) and 3,4-dihyroxybenzoic acid (2) showed selective inhibition against elastase release and superoxide anion generation, with IC50 values of 3.20 and 6.21 microg/mL, respectively. Compound 1 had 7-fold better activity than the positive control against elastase release induced by human neutrophils. Overall, our studies demonstrated Tiankuizi (S. adoxoides) as a potential TCM and isolates 1 and 2 as promising lead compounds for neutrophilic inflammatory diseases.
    Keywords: Anti-Inflammatory Agents, Non-Steroidal -- Pharmacology ; Benzoates -- Pharmacology ; Neutrophil Infiltration -- Drug Effects ; Semiaquilegia -- Chemistry
    ISSN: 1934-578X
    E-ISSN: 15559475
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  • 7
    Language: English
    In: Natural Product Communications, February 2017, Vol.12(2)
    Description: A new polyoxygenated briarane diterpenoid, briarenol B (1), was isolated from the octocoral Briareum excavatum and its structure determined from spectroscopic data. In RAW264.7 cells, a macrophage-like murine cell line, briarane B (1) was found to enhance the protein expression of pro-inflammatory cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS) in cells stimulated by lipopolysaccharide (LPS).
    Keywords: Briareum Excavatum ; Octocoral ; Briarane ; Briarenol ; Cox-2 ; Inos ; Chemistry
    ISSN: 1934-578X
    E-ISSN: 1555-9475
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  • 8
    Language: English
    In: Natural product communications, November 2012, Vol.7(11), pp.1415-7
    Description: Euphorbia neriifolia L. is a spiny herb native to Southeast Asia and currently cultivated in southern Taiwan. From the ethanolic extract of E. neriifolia leaves, 23 compounds were isolated, including 22 triterpenoids and one flavonoid glycoside. The anti-human coronavirus (HCoV) activity of the separated triterpenoids was studied revealing the structure-activity relationship (SAR) of these isolates. 3beta-Friedelanol exhibited more potent anti-viral activity than the positive control, actinomycin D, which implies the importance of the friedelane skeleton as a potential scaffold for developing new anti-HCoV-229E drugs.
    Keywords: Coronavirus ; Antiviral Agents -- Isolation & Purification ; Euphorbia -- Chemistry ; Triterpenes -- Isolation & Purification
    ISSN: 1934-578X
    E-ISSN: 15559475
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  • 9
    Language: English
    In: Natural Product Communications, January 2016, Vol.11(1)
    Description: One new secoiridoid glucoside, ethylsecologanin dimethyl acetal (1), along with 15 known compounds, comprising six iridoid glucosides (2–7), six flavonoids (8–13), two sterol glucosides (14 and 15), and chlorogenic acid (16) were isolated from the flower buds of Formosan Lonicera japonica. The structures of these isolates were determined on the basis of mass and spectroscopic analyzes. In addition, the chemical profiles of fresh Formosan honeysuckle buds and the dried Chinese one were compared by HPLC with a PDA detector. The calibration curve of the active component, chlorogenic acid, was also provided. As a result of the constituent similarity, Formosan L. japonica can be an alternative to the Chinese honeysuckles.
    Keywords: Secoiridoid Glycoside ; Lonicera Japonica ; Chlorogenic Acid ; Chemistry
    ISSN: 1934-578X
    E-ISSN: 1555-9475
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  • 10
    Language: English
    In: Natural Product Communications, 06/2016, Vol.11(6), p.1934578X1601100
    ISSN: 1934-578X
    E-ISSN: 1555-9475
    Source: Sage Publications (via CrossRef)
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