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  • Wiley (CrossRef)  (324)
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  • 1
    In: Pigment Cell & Melanoma Research, September 2015, Vol.28(5), pp.488-489
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/pcmr.12389/abstract Byline: Peter Dietrich, Anja Katrin Bosserhoff ***** No abstract is available for this article. ***** Article Note: Coverage on: Shoshan E, Mobley AK, Braeuer RR, Kamiya T, Huang L, Vasquez ME, Salameh A, Lee HJ, Kim SJ, Ivan C, Velazquez-Torres G, Nip KM, Zhu K, Brooks D, Jones SJ, Birol I, Mosqueda M, Wen YY, Eterovic AK, Sood AK, Hwu P, Gershenwald JE, Robertson AG, Calin GA, Markel G, Fidler IJ, Bar-Eli M. (2015) Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis. Nat. Cell Biol. 17(3), 311-321. doi: 10.1038/ncb3110.
    Keywords: Melanoma ; Microrna;
    ISSN: 1755-1471
    E-ISSN: 1755-148X
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  • 2
    In: Pigment Cell & Melanoma Research, May 2018, Vol.31(3), pp.350-351
    Description: Byline: Peter Dietrich,Anja Katrin Bosserhoff ***** No abstract is available for this article. ***** Article Note: Coverage on: Gilot, D., Migault, M., Bachelot, L., Journe, F., Rogiers, A., Donnou-Fournet, E., Mogha, A., Mouchet, N., Pinel-Marie, M.-L., Mari, B., Montier, T., Corre, S., Gautron, A., Rambow, F., El Hajj, P., Ben Jouira, R., Tartare-Deckert, S., Marine, J.-C., Felden, B., Ghanem, G., Galibert, M.-D. (2017). A noncoding function of TYRP1 mRNA promotes melanoma growth. Nature Cell Biology Oct 9. https://doi.org/10.1038/ncb3623.
    Keywords: Tumors ; Melanoma ; Cells (Biology) ; Microrna;
    ISSN: 1755-1471
    E-ISSN: 1755-148X
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  • 3
    In: Pigment Cell & Melanoma Research, July 2016, Vol.29(4), pp.399-401
    Description: Byline: Peter Dietrich, Anja Katrin Bosserhoff ***** No abstract is available for this article. ***** Article Note: Coverage on: Micevic, G., Muthusamy, V., Damsky, W., Theodosakis, N., Liu, X., Meeth, K., Wingrove, E., Santhanakrishnan, M., and Bosenberg, M. (2016). DNMT3b modulates melanoma growth by controlling levels of mTORC2 component RICTOR. Cell Rep. 14(9), 2180-2192.
    Keywords: DNA (Cytosine-5-)-Methyltransferases–Physiology ; Humans–Physiology ; Mechanistic Target of Rapamycin Complex 2–Physiology ; DNA (Cytosine-5-)-Methyltransferases ; DNA Methyltransferase 3b ; Mechanistic Target of Rapamycin Complex 2;
    ISSN: 1755-1471
    E-ISSN: 1755-148X
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  • 4
    In: Ground Water, May 2012, Vol.50(3), pp.450-456
    Description: Detailed information on vertical variations in hydraulic conductivity () is essential to describe the dynamics of groundwater movement at contaminated sites or as input data used for modeling. values in high vertical resolution should be determined because tends to be more continuous in the horizontal than in the vertical direction. To determine in shallow unconsolidated sediments and in the vertical direction, the recently developed direct‐push injection logger can be used. The information obtained by this method serves as a proxy for and has to be calibrated to obtain quantitative values of measured vertical profiles. In this study, we performed direct‐push soil sampling, sieve analyses and direct‐push slug tests to obtain values in vertical high resolution. Using the results of direct‐push slug tests, quantitative values obtained by the direct‐push injection logger could be determined successfully. The results of sieve analyses provided lower accordance with the logs due to the inherent limitations of the sieving method.
    Keywords: Hydrogeology ; Environmental Geology ; Aquifers ; Central Europe ; Elbe River ; Europe ; Experimental Studies ; Germany ; Granulometry ; Ground Water ; Hydraulic Conductivity ; Injection ; Measurement ; Mobility ; Pirna Germany ; Pollution ; Preferential Flow ; Sampling ; Saxony Germany ; Sediments ; Soils ; Unconsolidated Materials ; Variations;
    ISSN: 0017-467X
    E-ISSN: 1745-6584
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  • 5
    Language: English
    In: Journal of Plant Nutrition and Soil Science, June 2012, Vol.175(3), pp.345-354
    Description: Today rapid survey methods of proximal soil sensing (PSS) provide an increasing number of different and highly resolved data. These multidimensional data sets can lead to multilayered and complex maps of parameters which are only indirectly related to soil properties and soil functions. However, in applications usually just one clear elementary map is required. It is of increasing importance to tackle this problem utilizing a cluster algorithm for the synthesis and reduction of multidimensional input variables. The cluster algorithm provides a partitioning of the investigated site whereby the units are characterized by the statistics of the PSS data. Therefore, the question that arises is how suitable is the suggested partitioning in terms of the delineation of different soil units. In this study, we investigate the suitability of cluster partitioning through a case study at a medium‐scale test site (≈ 50 000 m). Two common PSS methods: electromagnetic induction (EMI) and gamma spectrometry (GS) will be employed to create a data set for partitioning by a K‐means cluster. The result of the cluster analysis is a delineation of three different parts. In contrast to previous studies, we evaluate the generated partitions by independent soil properties such as grain size, horizon thickness, and color of stratified randomly taken soil samples. The soil analyses show that one of three clusters significantly differs from the others in terms of grain‐size distribution and horizon thickness. The partitioning of the other two clusters could not be confirmed by the considered soil parameters. Nevertheless, the case study demonstrates the combination of different PSS data by K‐means clustering as a potential approach for site partitioning. An evaluation of the results of the cluster analysis through the collection and analysis of soil samples is highly recommended.
    Keywords: Site Partitioning ; Proximal Soil Sensing ; Rapid Soil Survey ; Cluster Analysis ; Emi ; Gamma Spectrometry ; Site‐Specific Crop Management Sscm
    ISSN: 1436-8730
    E-ISSN: 1522-2624
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  • 6
    In: Pigment Cell & Melanoma Research, September 2018, Vol.31(5), pp.614-629
    Description: The network of molecular players is similar when comparing neural crest‐derived, actively migrating melanoblasts to melanoma cells. However, melanoblasts are sensitive to differentiation‐initiating signals at their target site (epidermis), while melanoma cells maintain migratory and undifferentiated features. We aimed at identifying downregulated genes in melanoma that are particularly upregulated in melanoblasts. Loss of such genes could contribute to stabilization of a dedifferentiated, malignant phenotype in melanoma. We determined that micro‐622 (miR‐622) expression was strongly downregulated in melanoma cells and tissues compared to melanocytes and melanoblast‐related cells. miR‐622 expression correlated with survival of patients with melanoma. miR‐622 re‐expression inhibited clonogenicity, proliferation, and migration in melanoma. Inhibition of miR‐622 in melanocytes induced enhanced migration. Kirsten rat sarcoma () was identified as a major functional target of miR‐622 in melanoma. We conclude that miR‐622 is a novel tumor suppressor in melanoma and identify the miR‐622‐ axis as potential therapeutic target.
    Keywords: Kras ; Melanoma ; Micro Rna
    ISSN: 1755-1471
    E-ISSN: 1755-148X
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  • 7
    In: Groundwater, November 2012, Vol.50(6), pp.935-942
    Description: Knowledge of site‐specific contaminant transport processes is an essential requirement for performing various tasks concerning the protection and management of groundwater resources. However, prediction of their behavior is often difficult, especially in heterogeneous aquifers because of the lack of information about flow‐ and transport‐governing subsurface structures and parameters. Hence, stochastic approaches have been developed and frequently used. However, extensive modeling studies on sedimentary structures have shown that consideration of hydrogeological subunits and their distribution can be essential for transport modeling. A case study from the intensely investigated Lauswiesen site is used to demonstrate that more accurate predictions are possible with improved knowledge of deterministic structures. Results of this case study using direct‐push injection logging (DPIL) provide a more reliable characterization of hydraulic conductivity than sieve and flow meter data.
    Keywords: Hydrogeology ; Environmental Geology ; Alluvium Aquifers ; Aquifers ; Baden-Wurttemberg Germany ; Central Europe ; Characterization ; Cluster Analysis ; Europe ; Experimental Studies ; Germany ; Ground Water ; Heterogeneous Materials ; Hydraulic Conductivity ; Lauswiesen Site ; Models ; Neckar River ; Permeability ; Pollutants ; Pollution ; Porous Materials ; Preferential Flow ; Pump Tests ; Statistical Analysis ; Stochastic Processes ; Transport ; Tubingen Germany ; Univariate Analysis;
    ISSN: 0017-467X
    E-ISSN: 1745-6584
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  • 8
    Language: English
    In: Psychological Science, April 2004, Vol.15(4), pp.282-285
    Description: Research has shown that backward masking is a powerful tool for studying unconscious mental processes. Whereas studies have traditionally presented stimuli using cathode-ray tube (CRT) monitors or mechanical shutters together with slide projectors, recent studies (mainly in functional magnetic resonance imaging, fMRI) have begun to use methods based on liquid crystal displays (LCDs) and thin-film transistor (TFT) technology. However, because of differences in technology, all methods may not be equally suited for masking. When methods were compared for their accuracy in presenting pictures at short durations, LCD and TFT presentations had poor accuracy, but shutter and CRT presentations had better accuracy. Because CRTs interfere with the imaging process in fMRI, we recommend the use of mechanical shutters. However, our results may not generally apply to all displays, so we advise researchers to validate the presentation parameters of their displays. The procedure described here may be useful for that purpose.
    Keywords: Psychology
    ISSN: 0956-7976
    E-ISSN: 1467-9280
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  • 9
    In: Liver International, December 2015, Vol.35(12), pp.2556-2563
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/liv.12874/abstract Byline: Johannes Hartl, Peter Dietrich, Lukas Moleda, Martina Muller-Schilling, Reiner Wiest Keywords: cirrhosis; hyperdynamic circulatory syndrome; Neuropeptide Y; portal hypertension; splanchnic vasodilatation; vasoconstriction Abstract Background & Aims Vascular hyporeactivity to vasoconstrictors contributes to splanchnic arterial vasodilatation and hemodynamic dysregulation in portal hypertension. Neuropeptide Y (NPY), a sympathetic cotransmitter, has been shown to improve adrenergic vascular contractility in portal hypertensive rats and markedly attenuate hyperdynamic circulation. To further characterize the NPY-effects in portal hypertension, we investigated its role for non-receptor-mediated vasoconstriction in the superior mesenteric artery (SMA) of portal vein ligated (PVL) and sham-operated rats. Methods Ex vivo SMA perfusion of PVL and sham rats was used to analyse the effects of NPY on pressure response to non-receptor-mediated vasoconstriction. Dose-response curves to KCl (30-300 mM) were used to bypass G protein-coupled receptor mechanisms. Potential involvement of the cyclooxygenase-pathway was tested by non-selective cyclooxygenase-inhibition using indomethacin. Results KCl-induced vascular contractility but not vascular sensitivity was significantly attenuated in PVL rats as compared with sham rats. Administration of NPY resulted in an augmentation of KCl-evoked vascular sensitivity being not different between study groups. However, KCl-induced vascular contractility was markedly more enhanced in PVL rats, thus, vascular response was no more significantly different between PVL and sham rats after addition of NPY. Administration of indomethacin abolished the NPY-induced enhancement of vasoconstriction. Conclusions Receptor-independent vascular contractility is impaired in mesenteric arteries in portal hypertension. NPY improves non-receptor mediated mesenteric vasoconstriction more effective in portal hypertension than in healthy conditions correcting splanchnic vascular hyporesponsiveness. This beneficial vasoactive action of NPY adds to its well known more pronounced effects on adrenergic vasoconstriction in portal hypertension making it a promising therapeutic agent in portal hypertension. Article Note: Handling Editor: Christophe Bureau
    Keywords: Cirrhosis ; Hyperdynamic Circulatory Syndrome ; Neuropeptide Y ; Portal Hypertension ; Splanchnic Vasodilatation ; Vasoconstriction
    ISSN: 1478-3223
    E-ISSN: 1478-3231
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  • 10
    In: Water Resources Research, November 2016, Vol.52(11), pp.8970-8985
    Description: In earlier work, we presented a geostatistical assessment of high‐resolution hydraulic conductivity () profiles obtained at the MADE site using direct‐push (DP) methods. The profiles are derived from direct‐push injection logger (DPIL) measurements that provide a relative indicator of vertical variations in with a sample spacing of 1.5 cm. The DPIL profiles are converted to profiles by calibrating to the results of direct‐push permeameter (DPP) tests performed at selected depths in some of the profiles. Our original calibration used a linear transform that failed to adequately account for an upper limit on DPIL responses in high‐ zones and noise in the DPIL data. Here we present a revised calibration procedure that accounts for the upper limit and noise, leading to DPIL values that display a somewhat different univariate distribution and a lower ln variance (5.9 ± 1.5) than the original calibration values (6.9 ± 1.8), although each variance estimate falls within the other's 95% confidence interval. Despite the change in the univariate distribution, the autocorrelation structure and large‐scale patterns exhibited by the revised DPIL values still agree well with those exhibited by the flowmeter data from the site. We provide the DPIL and DPP data, along with our calibrated DPIL values, in the Supporting Information. Revised calibration of MADE direct‐push data better reflects tool behavior Revisions improve representation of high hydraulic conductivity zones Autocorrelation structure and large‐scale patterns change little
    Keywords: Aquifer Characterization ; Direct‐Push
    ISSN: 0043-1397
    E-ISSN: 1944-7973
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