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  • Wiley (CrossRef)  (23)
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  • 1
    In: Security and Communication Networks, November 2013, Vol.6(11), pp.1310-1318
    Description: One of the benefits of virtualization technology is the provision of secure and isolated computing environments on a single physical machine. However, the use of virtual machines for this purpose often degrades the overall system performance that is due to emulation costs, for example, packet filtering on every virtual machine. To allow virtual machines to be favorably used as before for the provision of secure environments but with comparably less performance degradation, we propose a new architecture called Alamut in this paper for restructuring any typical network intrusion detection system (NIDS) to run in a Xen‐based virtual execution environment. In the proposed architecture, primitive mechanisms for implementing the security concerns of typical NIDSs such as signature matching are placed at the kernel level of driver domain (dom0), whereas security policies and management modules are kept in user space of that domain. Separation of mechanisms from policies allows network packets to be verified at the kernel level first hand more efficiently without requiring costly context switches to push them to user space for validation. In addition, system administrators can easily define new policies at user level and determine on which virtual machines these policies should be enforced. A proof‐of‐concept implementation of Alamut has been prototyped on the Xen hypervisor using Bro open‐source NIDS. Experimental results show approximately 3.5‐fold increase in the overall system performance when our prototype is run compared with when Bro is run. Results also show 19% improvement in network throughput. The comparison of Alamut with Snort with the same set of signatures and attacks shows that our prototyped NIDS has lower processor utilization and has captured more packets in heavy network loads. Copyright © 2013 John Wiley & Sons, Ltd. This paper presents Alamut, a new architecture for network intrusion detection systems (NIDSs) in support of Xen‐based virtualized environments. In the design of Alamut, the base primitive modules of an NIDS (Bro in our case) are moved to the kernel space of dom0, whereas the rest parts are kept at user space. Evaluation results show that Alamut outperforms Snort and user mode Bro.
    Keywords: Intrusion Detection System ; Virtualization Technology ; Security ; Performance ; Xen
    ISSN: 1939-0114
    E-ISSN: 1939-0122
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  • 2
    Language: English
    In: Journal of Applied Social Psychology, June, 2013, Vol.43(6), p.1211(17)
    Description: Byline: Ehsan Mousavi Khaneghah, Seyedeh Leili Mirtaheri, Behrouz Minaei-Bidgoli, Mohsen Sharifi, Mohammad Reza Mani Yekta, Abbas Saleh Ardestani, Zarrintaj Bornaee Abstract This paper presents a model for resolving two main issues of time in e-commerce. The first issue is the time value of e-commerce that represents the value of each moment of the commerce time from the perspective of buyers and sellers. Buyers and sellers can use this model to calculate the time value at each moment of time and accordingly decide whether it is profitable to buy or sell at that moment. The second issue is to allow buyers or sellers to increase their savings or decrease their costs by changing each of the factors governing the time value model of the concerned e-commerce. We present relevant model specifically for Amazon e-commerce to present a proof of concept of our proposed models. Author Affiliation:
    Keywords: E-commerce -- Analysis
    ISSN: 0021-9029
    E-ISSN: 15591816
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  • 3
    In: Clinical Cardiology, February 2014, Vol.37(2), pp.78-82
    Description: Byline: Mohsen Sharifi, Curt Bay, Frederic Schwartz, Laura Skrocki ABSTRACT Background Thrombolysis, though very effective, has not been embraced as routine therapy for symptomatic pulmonary embolism (PE) except in very severe cases. Rivaroxaban recently has been approved for the treatment of venous thromboembolism (VTE). There are no data on the combined use of thrombolysis and rivaroxaban in PE. Hypothesis "Safe dose" thrombolysis (SDT) plus new oral anticoagulants are expected to become an appealing, safe and effective approach in the treatment of moderate and severe PE in the near future, thereby drastically reducing hospitalization time. Methods Over a 12-month period, 98 consecutive patients with symptomatic PE were treated by a combination of SDT and rivaroxaban. The SDT was started in parallel with unfractionated heparin and given in 2 hours. Heparin was given for a total of 24 hours and rivaroxaban started at 15 or 20 mg daily 2 hours after termination of heparin infusion. Results There was no bleeding due to SDT. Recurrent VTE occurred in 3 patients who had been switched to warfarin. No patient on rivaroxaban developed VTE. Two patients died of cancer at a mean follow-up of 12 [+ or -] 2 months. The pulmonary artery systolic pressure dropped from 52.8 [+ or -] 3.9 mm Hg before to 32 [+ or -] 4.4 mm Hg within 36 hours of SDT (P 0.001). The duration of hospitalization for patients presenting primarily for PE was 1.9 [+ or -] 0.2 days. Conclusions "Safe dose" thrombolysis plus rivaroxaban is highly safe and effective in the treatment of moderate and severe PE, leading to favorable early and intermediate-term outcomes and early discharge. Author Affiliation: Arizona Cardiovascular Consultants and Vein Clinic, Mesa, Arizona A. T. Still University, Mesa, Arizona
    Keywords: Pulmonary Embolism -- Drug Therapy ; Thromboembolism -- Drug Therapy ; Heparin ; Warfarin;
    ISSN: 0160-9289
    E-ISSN: 1932-8737
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  • 4
    Language: English
    In: Catheterization and Cardiovascular Interventions, 01 April 2010, Vol.75(5), pp.685-689
    Description: Venous thromboembolic disease is an underdiagnosed disease spectrum with a high mortality and morbidity. Despite significant advances in cardiovascular interventions, venous occlusive disease has not received the attention it deserves from the interventional cardiology community. We describe an 82‐year‐old man with massive left lower extremity DVT who underwent successful percutaneous endovenous intervention (PEVI) with rapid resolution of symptoms. We like to use this case as a call to action and raise awareness of the importance of PEVI in the treatment of extensive venous occlusive disease. © 2009 Wiley‐Liss, Inc.
    Keywords: Deep Venous Thrombosis ; Thrombectomy ; Thrombolytic Therapy
    ISSN: 1522-1946
    E-ISSN: 1522-726X
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  • 5
    In: Cell Biology International, September 2019, Vol.43(9), pp.1040-1048
    Description: The study of the genome and the proteome of different species and representatives of distinct kingdoms, especially detection of proteome via wide-scaled analyses has various challenges and pitfalls. Attempts to combine all available information together and isolate some common features for determination of the pathway and their mechanism of action generally have a highly complicated nature. However, microtubule (MT) monomers are highly conserved protein structures, and microtubules are structurally conserved from Homo sapiens to Arabidopsis thaliana. The interaction of MT elements with microtubule-associated proteins and post-translational modifiers is fully dependent on protein interfaces, and almost all MT modifications are well described except acetylation. Crystallography and interactome data using different approaches were combined to identify conserved proteins important in acetylation of microtubules. Application of computational methods and comparative analysis of binding modes generated a robust predictive model of acetylation of the ϵ-amino group of Lys40 in α-tubulins. In turn, the model discarded some probable mechanisms of interaction between elements of interest. Reconstruction of unresolved protein structures was carried out with modeling by homology to the existing crystal structure (PDBID: 1Z2B) from B. taurus using Swiss-model server, followed by a molecular dynamics simulation. Docking of the human tubulin fragment with Lys40 into the active site of α-tubulin acetyltransferase, reproduces the binding mode of peptidomimetic from X-ray structure (PDBID: 4PK3).
    Keywords: Α‐Tubulin Acetyltransferase ; Arabidopsis Thaliana ; Deacetylation ; Sirtuin Type 2 ; Histone Deacetylase ; Microtubules ; Post‐Translational Modifications
    ISSN: 1065-6995
    E-ISSN: 1095-8355
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  • 6
    Language: English
    In: Catheterization and Cardiovascular Interventions, 01 September 2010, Vol.76(3), pp.316-325
    Description: We compared the efficacy and safety of percutaneous endovenous intervention (PEVI) plus anticoagulation with anticoagulation alone in the reduction of venous thromboembolism (VTE) and post‐thrombotic syndrome (PTS) in acute proximal deep venous thrombosis (DVT). Recurrent VTE and PTS are common complications of DVT. There are no randomized trials investigating the efficacy of PEVI in the reduction of the above complications. Patients with symptomatic proximal DVT were randomized to receive PEVI plus anticoagulation or anticoagulation alone. Anticoagulation consisted of intravenous unfractionated heparin or subcutaneous low‐molecular weight heparin plus warfarin. PEVI consisted of one or more of a combination of thrombectomy, balloon venoplasty, stenting, or local low‐dose thrombolytic therapy. At 6 months follow‐up, recurrent VTE developed in 2 of 88 patients of the PEVI plus anticoagulation group versus 12 of 81of the anticoagulation‐alone group (2.3% vs. 14.8%, = 0.003). PTS developed in 3 of 88 patients of the PEVI plus anticoagulation Group and 22 of 81 of the anticoagulation‐alone group (3.4% vs. 27.2%, 〈 0.001). In patients with symptomatic proximal DVT, PEVI plus anticoagulation may be superior to anticoagulation—alone in the reduction of VTE and PTS at 6 months. © 2010 Wiley‐Liss, Inc.
    Keywords: Peripheral Vascular Disease ; Thrombosis ; Coagulation
    ISSN: 1522-1946
    E-ISSN: 1522-726X
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  • 7
    In: Echocardiography, April 2007, Vol.24(4), pp.397-400
    Description: Purpose: Transesophageal echocardiography has emerged as an accepted approach before D.C. cardioversion for atrial fibrillation. The frequency of atrial thrombi detected on transesophageal echocardiography has varied from 7% to 23%. Many patients undergoing transesophageal echocardiography have had a previous transthoracic echocardiogram. Though transthoracic echocardiography has a low yield for the detection of intracardiac thrombi, it is highly accurate in diagnosing a structurally abnormal heart. The purpose of this study was to assess the frequency of thrombi detected by transesophageal echocardiography in patients with an entirely normal transthoracic echocardiogram and hence the advocacy of a selective approach in performing transesophageal echocardiography in patients undergoing D.C. cardioversion for atrial fibrillation. Methods: 112 consecutive patients with atrial fibrillation who had undergone transesophageal echocardiography before D.C. cardioversion were evaluated. They all had a transthoracic echocardiogram within the 2 months preceding their transesophageal echocardiogram. Based on their transthoracic echocardiographic study, they were divided into two groups: Group 1 consisted of patients with a normal transthoracic echocardiogram and Group 2, those with an abnormal study. Results: Thrombi or spontaneous echo contrast were found in 14 of 112 patients (16%). All however were detected in Group 2 patients. There was no patient with a normal transthoracic echocardiogram who had thrombus on his/her transesophageal echocardiogram. Conclusions: Our results suggest that a selective approach may be exercised in the use of transesophageal echocardiography prior to D.C. cardioversion for atrial fibrillation. Patients with an entirely “normal” transthoracic echocardiogram may proceed directly to cardioversion without a precardioversion transesophageal echocardiogram.
    Keywords: Atrial Fibrillation ; Transesophageal Echocardiography ; Cardioversion
    ISSN: 0742-2822
    E-ISSN: 1540-8175
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  • 8
    In: Pacing and Clinical Electrophysiology, October 1994, Vol.17(10), pp.1691-1696
    Description: Three patients with inadvertently positioned left heart pacemaker leads were admitted for neurological symptoms consistent with embolic stroke. In one of them, the pacemaker lead crossed the interatrial septum, the mitral valve, and entered the left ventricle. In another it was erroneously placed through the subclavian artery, across the aortic valve, and into the left ventricular chamber In the third patient, the right ventricular lead of a DDD pacemaker was placed in the coronary sinus and the right atrial lead crossed the interatrial septum, and intermittently entered the left ventricular cavity. Once anticoagulation was initiated, symptoms resolved; they recurred when the level of anticoagulation dropped leading to a major stroke in one of the patients. Two of the patients were on aspirin at the onset of symptoms. We believe that every approach must be considered to remove the malpositioned lead. Otherwise, full dose anticoagulation must be initiated since antiplatelet therapy alone does not confer adequate protection against stroke.
    Keywords: Transvenous Pacemaker ; Thromboembolism ; Cerebral Stroke
    ISSN: 0147-8389
    E-ISSN: 1540-8159
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  • 9
    Article
    Article
    Language: English
    In: Journal of Corporate Accounting & Finance, January 2006, Vol.17(2), pp.37-44
    Description: The Sarbanes‐Oxley Act (SOX) has fundamentally altered the legal landscape for corporate governance and financial reporting. But it has also had a profound effect on M&A—as a menacing “deal killer.” How can you stop SOX from souring your deal?
    Keywords: United States ; Us ; Public Company Accounting Reform & Investor Protection Act 2002-Us ; Acquisitions & Mergers ; Corporate Governance ; Financial Reporting;
    ISSN: 1044-8136
    E-ISSN: 1097-0053
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  • 10
    Language: English
    In: Catheterization and Cardiovascular Interventions, October 2004, Vol.63(2), pp.255-255
    Keywords: Balloon Occlusion -- Adverse Effects ; Epilepsy -- Etiology ; Heart Septal Defects, Atrial -- Surgery ; Migraine Disorders -- Drug Therapy ; Platelet Aggregation Inhibitors -- Therapeutic Use ; Ticlopidine -- Analogs & Derivatives;
    ISSN: 1522-1946
    E-ISSN: 1522-726X
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