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  • Wiley Online Library  (15)
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  • 1
    In: International Journal of Urology, June 2013, Vol.20(6), pp.585-592
    Description: Byline: Sandra Steffens, Kristina I Ringe, Katharina Schroeer, Rieke Lehmann, Julia Rustemeier, Gerd Wegener, Mark Schrader, Rainer Hofmann, Markus A Kuczyk, Andres J Schrader, Keywords: body mass index; body surface area; obesity; prognosis; renal cell carcinoma; risk factors; visceral fat Objectives To assess the impact of overweight on prognosis of renal cell carcinoma patients. Patients And Methods A total of 2030 patients who underwent surgery for renal cell carcinoma from 1990 to 2011 in three University Medical Centers were included in this retrospective analysis. For all patients, height and weight measurements at the time of diagnosis were available for review. The median (mean) follow up was 56.6 months (66.0 months). Results A low body mass index was significantly associated with poor tumor differentiation, histology, microscopic vascular invasion and metastatic disease at the time of diagnosis. A lower-than-average body surface area - stratified according to the European average for men (1.98m.sub.2) and women (1.74m.sub.2) - was significantly related to older age, poor tumor differentiation, the histological subtype and microscopic vascular invasion. In addition, a low visceral fat area calculated in a subgroup of 133 evaluable patients was associated with a higher risk of advanced disease (pT3-4 and/or N/M+) at diagnosis. The tumor-specific 5-year survival rate was 71.3, 78.7 and 80.1%, for patients with a body mass index of, 〈25, 25-30 and a[yen]30. Multivariate analysis confirmed body mass index as an independent prognostic factor. Conclusion Our findings suggest that overweight represents an independent prognostic factor in renal cell carcinoma patients. Further research should address the question of why obese people have a higher incidence of renal cell carcinoma, but at the same time a significantly better prognosis than other patients, particularly in the case of localized disease. Author Affiliation:
    Keywords: Body Mass Index ; Body Surface Area ; Obesity ; Prognosis ; Renal Cell Carcinoma ; Risk Factors ; Visceral Fat
    ISSN: 0919-8172
    E-ISSN: 1442-2042
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  • 2
    In: International Wound Journal, December 2011, Vol.8(6), pp.578-584
    Description: We analysed the effect of different body features on contact area, interface pressure and pressure distribution of three different mattresses. Thirty‐eight volunteers (age ranged from 17 to 73 years, 23 females) were asked to lie on three different mattresses in a random order: I, standard hospital foam mattresses; II, higher specification foam mattresses (Viscorelax Sure); III, constant low pressure devices (CareMedx, AirSystems). Measurements were performed in supine position and in a 90° left‐ and right‐sided position, respectively, using a full‐body mat (pressure mapping device Xsensor X2‐Modell). Outcome variables were contact area (CA) in cm, mean interface pressure (IP) in mmHg and pressure distribution (PD) estimated as rate of low pressures between 5 and 33 mmHg on each mattress in percent. Mean CA was lowest in the standard hospital foam mattresses and increased in the higher specification foam mattresses and was highest in the constant low pressure device (supine position: 491 ± 86 cm, 615 ± 95 cm, 685 ± 116 cm). Mean IP was highest in the standard hospital foam mattresses and lower but similar in the higher specification foam mattresses and the constant low pressure devices (supine position: 22·3 ± 1·5 mmHg, 17·6 ± 1·7 mmHg, 17·6 ± 2·2 mmHg). Models were estimated for CA, IP and PD including the independent variables height, weight and waist‐to‐hip‐ratio (WHR). They show that body morphology seems to play a minor role for CA, IP and PD, but very thin and tall patients and very small and obese people might benefit from different mattresses. Our data show that CA increases with increasing specification of mattresses. Higher specification foam mattresses and constant low pressure devices show similar IP, but constant low pressure devices show a wider pressure distribution. Body morphology should be considered to optimise prevention for single patients.
    Keywords: Interface Pressure ; Mattresses ; Pressure Ulcer ; Waist‐To‐Hip‐Ratio
    ISSN: 1742-4801
    E-ISSN: 1742-481X
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  • 3
    Language: German
    In: Justus Liebigs Annalen der Chemie, 28 September 1962, Vol.657(1), pp.1-4
    Description: Silylderivate gasförmiger Amine werden aus Chlorsilanen und Dchen Lösungen gewonnen. Der Mechanismus der Reaktion wird an Hand von Umsetzungen des Trimethylchlorsilans mit Dchen Lösungen aus Amingemischen aufgeklärt.
    ISSN: 0075-4617
    E-ISSN: 1099-0690
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  • 4
    In: Laryngoscope Investigative Otolaryngology, October 2017, Vol.2(5), pp.325-330
    Description: Objectives/Hypothesis: The time course of the reinnervation of the paralyzed face after hypoglossal-facial jump nerve suture using electromyography (EMG) was assessed. The relation to the clinical outcome was analyzed.Study Design: Retrospective single-center cohort study.Methods: Reestablishment of motor units was studied by quantitative EMG and motor unit potential (MUP) analysis in 11 patients after hypoglossal-facial jump nerve suture. Functional recovery was evaluated using the Stennert index (0 = normal; 10 = maximal palsy).Results: Clinically, first movements were seen between 6 and 〉10 months after surgery in individual patients. Maximal improvement was achieved at 18 months. The Stennert index decreased from 7.9 ± 2.0 preoperatively to a final postoperative score of 5.8 ± 2.4. EMG monitoring performed for 2.8 to 60 months after surgery revealed that pathological spontaneous activity disappeared within 2 weeks. MUPs were first recorded after the 2nd month and present in all 11 patients 8-10 months post-surgery. Polyphasic regeneration potentials first appeared at 4-10 months post-surgery. The MUP amplitudes increased between the 3rd and 15th months after surgery to values of control muscles. The MUP duration was significantly increased above normal values between the 3rd and 24th months after surgery.Conclusion: Reinnervation can be detected at least 2 months earlier by EMG than by clinical evaluation. Changes should be followed for at least 18 months to assess outcome. EMG changes reflected the remodeling of motor units due to axonal regeneration and collateral sprouting by hypoglossal nerve fibers into the reinnervated facial muscle fibers.Level of Evidence: 3b.
    Keywords: Facial Nerve ; Hypoglossal Nerve ; Cross‐Nerve Suture ; Nerve Repair ; Muscle Reinnervation ; Motor Unit Potential ; Emg ; Regeneration
    ISSN: 2378-8038
    ISSN: 0023852X
    E-ISSN: 2378-8038
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  • 5
    In: JDDG: Journal der Deutschen Dermatologischen Gesellschaft, August 2013, Vol.11(8), pp.768-779
    ISSN: 1610-0379
    E-ISSN: 1610-0387
    Source: John Wiley & Sons, Inc.
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  • 6
    In: JDDG: Journal der Deutschen Dermatologischen Gesellschaft, August 2013, Vol.11(8), pp.768-780
    ISSN: 1610-0379
    E-ISSN: 1610-0387
    Source: John Wiley & Sons, Inc.
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  • 7
    In: Liver Transplantation, January 2018, Vol.24(1), pp.15-25
    Description: Late allocation of organs for transplant impairs post–liver transplantation (LT) survival. Cardiac dysfunction, especially diastolic and autonomic dysfunction, is frequent and plays an important role in the prognosis of patients with cirrhosis. However, the role of myocardial contractility is unexplored, and its prognostic value is controversially discussed. This study analyses the role of myocardial contractility assessed by speckle tracking echocardiography in LT allocation. In total, 168 patients with cirrhosis (training cohort, 111; validation cohort [VC], 57) awaiting LT in 2 centers were included in this retrospective study. Also, 51 patients from the training and all patients from the VC were transplanted, 36 patients of the training and 38 of the VC were alive at the end of follow‐up, and 21 nontransplanted patients died. Contractility of the left ventricle (LV) increased with severity of the Child‐Pugh score. Interestingly, higher LV contractility in the training cohort patients, especially in those with Child‐Pugh C, was an independent predictor of reduced transplant‐free survival. In male patients, the effects on survival of increased left and right ventricular myocardial contractility were more pronounced. Notably, competing risk analysis demonstrated that increased contractility is associated with earlier LT, which could be confirmed in the VC. Importantly, LV myocardial contractility had no impact on survival of patients not receiving LT or on post‐LT survival. In conclusion, this study demonstrates for the first time that increased myocardial contractility in decompensated patients identifies patients who require LT earlier, but without increased post‐LT mortality. AASLD.
    Keywords: Liver Transplantation ; Myocardial Contraction ; Patient Selection ; End Stage Liver Disease -- Surgery ; Heart -- Physiopathology ; Liver Cirrhosis -- Surgery;
    ISSN: 1527-6465
    E-ISSN: 1527-6473
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  • 8
    In: EMBO reports, January 2009, Vol.10(1), pp.101-101
    ISSN: 1469-221X
    E-ISSN: 1469-3178
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  • 9
    In: EMBO reports, December 2008, Vol.9(12), pp.1237-1243
    Description: Blm10, a crucial protease of eukaryotic cells, is bound to yeast proteasome core particles (CPs). Two gates, at both ends of the CP, control the access of protein substrates to the catalytic cavity of the CP. Normally, substrate access is auto‐inhibited by a closed gate conformation unless regulatory complexes are bound to the CP and translocate protein substrates in an ATP‐dependent manner. Here, we provide evidence that Blm10 recognizes pre‐activated open gate CPs, which are assumed to exist in an equilibrium with inactive closed gate CP. Consequently, single‐capped Blm10‐CP shows peptide hydrolysis activity. Under conditions of disturbed CP assembly, as well as in open gate mutants, pre‐activated CP or constitutively active CP, respectively, prevail. Then, Blm10 sequesters disordered and open gate CP by forming double‐capped Blm10‐CP in which peptide hydrolysis activity is repressed. We conclude that Blm10 distinguishes between gate conformations and regulates the activation of CP.
    Keywords: Medicine ; Biology;
    ISSN: 1469-221X
    E-ISSN: 1469-3178
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  • 10
    Language: English
    In: FEBS Letters, 1999, Vol.463(1), pp.160-164
    Description: RANTES may be one of the chemoattractants involved in stimulating eosinophils and macrophages to migrate selectively into bovine dominant follicles and into developing corpora lutea. We sequenced a 736 bp fragment of the bovine RANTES mRNA encoding the complete protein and defined the ovarian source of RANTES mRNA. As demonstrated by competitive RT-PCR, follicle-derived macrophages showed a 100–1000 times higher RANTES mRNA level compared to unpurified granulosa cells or follicle-derived fibroblasts. By means of in situ hybridization, RANTES mRNA positive macrophages were located in the former thecal layer of the developing corpora lutea.
    Keywords: Bovine Rantes ; Ovary ; Macrophage ; Eosinophil ; Biology ; Chemistry ; Anatomy & Physiology
    ISSN: 0014-5793
    E-ISSN: 1873-3468
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