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  • 1
    UID:
    almafu_9958071814802883
    Format: 1 online resource (147 pages) : , illustrations, charts; digital, PDF file(s).
    Series Statement: Frontiers Research Topics
    Content: Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses such as the “Pediatric Cancer Translational Genomics” conference (Phoenix, Arizona, 2012), the ESF-EMBO workshop on “Molecular Biology and Innovative Therapies in Sarcomas” (Pultusk, Poland, 2012), and the AACR special meeting on “Pediatric Cancer at the Crossroads – Translating Discovery into Improved Outcomes” (San Diego, California, 2013) further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and that it would have great potential to receive numerous contributions of outstanding experts of the field. The proposed Frontiers Research Topic shall provide a platform for active and interdisciplinary discussion, summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and offer new perspectives of how to further promote and accelerate the translational process. We welcome high-quality original research articles, brief reports, as well as opinion, hypothesis, and review articles, and especially encourage submissions from early-career scientists.
    Note: English
    Additional Edition: ISBN 2-88919-819-7
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    UID:
    gbv_1778603831
    Format: 1 Online-Ressource (147 p.)
    ISBN: 9782889198191
    Series Statement: Frontiers Research Topics
    Content: Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses such as the “Pediatric Cancer Translational Genomics” conference (Phoenix, Arizona, 2012), the ESF-EMBO workshop on “Molecular Biology and Innovative Therapies in Sarcomas” (Pultusk, Poland, 2012), and the AACR special meeting on “Pediatric Cancer at the Crossroads – Translating Discovery into Improved Outcomes” (San Diego, California, 2013) further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and that it would have great potential to receive numerous contributions of outstanding experts of the field. The proposed Frontiers Research Topic shall provide a platform for active and interdisciplinary discussion, summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and offer new perspectives of how to further promote and accelerate the translational process. We welcome high-quality original research articles, brief reports, as well as opinion, hypothesis, and review articles, and especially encourage submissions from early-career scientists
    Note: English
    Language: English
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  • 3
    UID:
    almafu_9959327728602883
    Format: 1 online resource (xxix, 530 pages) : , illustrations
    ISBN: 9783527627523 , 3527627529 , 9783527627530 , 3527627537 , 1282118552 , 9781282118553
    Content: Summarizing molecular aspects, diagnostic as well as therapeutic issues, this book is the very first and most comprehensive on hereditary aspects of tumor diseases. All the contributors have been made fellows of the Ingrid zu Solms Foundation due to their outstanding achievements in scientific research, and they discuss here the latest aspects in the diagnosis, disease management, and treatment of hereditary tumor diseases and syndromes. A must-have ready reference for medical and biology students, MDs, PhDs, physicians, and researchers.
    Note: Hereditary Tumors; Foreword; Preface; Contents; List of Contributors; Part I Hereditary Tumors -- General Aspects; 1 General Insights Into Tumor Invasion, Progression, and Metastasis; 2 The Genetic Background of Hereditary Tumor Diseases; Part II Syndromal Types of Hereditary Tumors; 3 Family Cancer Syndromes; 4 Genetic Dysmorphic Syndromes Leading to Tumorigenesis; Part III Site-Specific Aspects of Hereditary Tumors; 5 Hereditary Brain Tumors; 6 Neurofibromatosis; 7 Retinoblastoma: The Prototypic Hereditary Tumor; 8 Hereditary Cancer in the Head and Neck.
    Additional Edition: Print version: Hereditary tumors. Weinheim : Wiley-VCH, ©2009 ISBN 9783527320288
    Additional Edition: ISBN 3527320288
    Language: English
    Keywords: Electronic books. ; Electronic books. ; Electronic books.
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  • 4
    UID:
    almafu_9959329079602883
    Format: 1 online resource (2 volumes) : , illustrations
    ISBN: 9783527619665 , 3527619666
    Additional Edition: Print version: Apoptosis and cancer therapy. Weinheim : Wiley-VCH, ©2006 ISBN 3527312374
    Additional Edition: ISBN 9783527312375
    Language: English
    Keywords: Electronic books. ; Electronic books. ; Electronic books.
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  • 5
    UID:
    edoccha_9958071814802883
    Format: 1 online resource (147 pages) : , illustrations, charts; digital, PDF file(s).
    Series Statement: Frontiers Research Topics
    Content: Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses such as the “Pediatric Cancer Translational Genomics” conference (Phoenix, Arizona, 2012), the ESF-EMBO workshop on “Molecular Biology and Innovative Therapies in Sarcomas” (Pultusk, Poland, 2012), and the AACR special meeting on “Pediatric Cancer at the Crossroads – Translating Discovery into Improved Outcomes” (San Diego, California, 2013) further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and that it would have great potential to receive numerous contributions of outstanding experts of the field. The proposed Frontiers Research Topic shall provide a platform for active and interdisciplinary discussion, summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and offer new perspectives of how to further promote and accelerate the translational process. We welcome high-quality original research articles, brief reports, as well as opinion, hypothesis, and review articles, and especially encourage submissions from early-career scientists.
    Note: English
    Additional Edition: ISBN 2-88919-819-7
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 6
    UID:
    edocfu_9958071814802883
    Format: 1 online resource (147 pages) : , illustrations, charts; digital, PDF file(s).
    Series Statement: Frontiers Research Topics
    Content: Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses such as the “Pediatric Cancer Translational Genomics” conference (Phoenix, Arizona, 2012), the ESF-EMBO workshop on “Molecular Biology and Innovative Therapies in Sarcomas” (Pultusk, Poland, 2012), and the AACR special meeting on “Pediatric Cancer at the Crossroads – Translating Discovery into Improved Outcomes” (San Diego, California, 2013) further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and that it would have great potential to receive numerous contributions of outstanding experts of the field. The proposed Frontiers Research Topic shall provide a platform for active and interdisciplinary discussion, summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and offer new perspectives of how to further promote and accelerate the translational process. We welcome high-quality original research articles, brief reports, as well as opinion, hypothesis, and review articles, and especially encourage submissions from early-career scientists.
    Note: English
    Additional Edition: ISBN 2-88919-819-7
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 7
    UID:
    almahu_9947381978302882
    Format: 1 online resource (147 pages) : , illustrations, charts; digital, PDF file(s).
    Series Statement: Frontiers Research Topics
    Content: Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses such as the “Pediatric Cancer Translational Genomics” conference (Phoenix, Arizona, 2012), the ESF-EMBO workshop on “Molecular Biology and Innovative Therapies in Sarcomas” (Pultusk, Poland, 2012), and the AACR special meeting on “Pediatric Cancer at the Crossroads – Translating Discovery into Improved Outcomes” (San Diego, California, 2013) further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and that it would have great potential to receive numerous contributions of outstanding experts of the field. The proposed Frontiers Research Topic shall provide a platform for active and interdisciplinary discussion, summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and offer new perspectives of how to further promote and accelerate the translational process. We welcome high-quality original research articles, brief reports, as well as opinion, hypothesis, and review articles, and especially encourage submissions from early-career scientists.
    Note: English
    Additional Edition: ISBN 2-88919-819-7
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 8
    UID:
    almahu_BV042065963
    Format: VIII, 382 S. : , Ill., graph. Darst. ; , 24 cm.
    ISBN: 978-94-017-8983-7
    Content: Includes bibliographical references
    Note: Mitochondria: The Anti- cancer Target for the Third Millennium
    Additional Edition: Erscheint auch als Online-Ausgabe ISBN 978-94-017-8984-4
    Language: English
    Subjects: Medicine
    RVK:
    RVK:
    Keywords: Krebszelle ; Mitochondrium ; Therapie ; Krebs ; Gentherapie ; Aufsatzsammlung
    Author information: Fulda, Simone, 1968-
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  • 9
    UID:
    almahu_BV010433939
    Format: 140 S. : Ill., graph. Darst.
    Note: Köln, Univ., Diss., 1995
    Language: German
    Keywords: Hochschulschrift
    Author information: Fulda, Simone, 1968-
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  • 10
    UID:
    gbv_1657881466
    Format: Online-Ressource (VIII, 382 p. 45 illus., 41 illus. in color, online resource)
    ISBN: 9789401789844
    Series Statement: SpringerLink
    Content: This book will be focused on mitochondria as very promising targets for anti-cancer drugs, yet to be fully exploited. It will contain chapters focused on aspects of basic research as well as on clinical relevance, which will be written by specialists in the field. That the role of mitochondria in human pathologies goes beyond the neoplastic diseases will be documented by a chapter of the role of mitochondria in Friedreich's ataxia.
    Content: Mitochondria: The anti-cancer target for the third millennium is a collection of up-to-date contributions investigating the role of these organelles in human pathology, in particular cancer. Written by experts in the area of mitochondrial research, this book covers topics ranging from the basic science of the role of mitochondria in cellular homeostasis to more focused topics on the interaction with drugs, emerging targets in pathology and platforms for the development of novel drugs. The book will appeal to researchers interested in the role of mitochondria in pathology and in the latest discoveries in this area of research
    Note: Description based upon print version of record , PrefaceMitochondrion: A novel center for cancer cell signalling -- Exploiting BH3 mimetics for cancer therapy -- Regulation of mitochondrial function by MicroRNA -- Mitochondrial complex II as a target for anti-cancer drugs -- Exploiting celecoxib in cancer therapy -- Activation of mitochondria-driven pathways by artemisinin and its derivatives -- Vitamin E analogues as prototypic mitochondria-targeting anti-cancer agents -- Targeting mitochondria of cancer cells: Mechanism and compounds -- Targets and strategies for the mitochondrial assault on cancer -- Emerging anti-cancer targets in mitochondria -- Relevance of mitochondrial functions and plasticity in tumor biology -- Crosstalk between p53 and mitochondrial metabolism -- Progression of cardiomyopathy in Friedreich’s ataxia, a mitochondrial disease -- Index.
    Additional Edition: ISBN 9789401789837
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-940-178-983-7
    Language: English
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
    Author information: Fulda, Simone 1968-
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