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  • 1
    UID:
    almafu_BV000635044
    Format: 297 S. : , graph. Darst.
    ISBN: 3-8100-0582-7 , 3-8100-0570-3
    Language: German
    Subjects: Sociology
    RVK:
    Keywords: Freizeitforschung ; Freizeitforschung ; Methode ; Freizeit ; Soziologie ; Aufsatzsammlung ; Aufsatzsammlung ; Aufsatzsammlung
    Author information: Agricola, Sigurd 1938-
    Author information: Lüdtke, Hartmut 1938-
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  • 2
    Book
    Book
    Stuttgart :Kohlhammer,
    UID:
    almafu_BV002253733
    Format: 114 S.
    ISBN: 3-17-004492-3
    Series Statement: Deutschland 〈Bundesrepublik〉 / Bundesminister für Jugend, Familie und Gesundheit: Schriftenreihe des Bundesministers ... . 117.
    Language: German
    Subjects: Education , Sociology
    RVK:
    RVK:
    Keywords: Freizeitgestaltung ; Personalstruktur ; Professionalisierung ; Freizeitgestaltung ; Freizeitgestaltung ; Personalbedarf
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  • 3
    Online Resource
    Online Resource
    Wiesbaden : VS Verlag für Sozialwissenschaften
    UID:
    b3kat_BV042459444
    Format: 1 Online-Ressource (297 S.)
    ISBN: 9783322925978 , 9783810005700
    Note: Dieser Sammelband vereinigt Beiträge von Psychologen, Soziologen, Geographen und Erziehungswissenschaftlern zur Methodologie der Freizeitforschung, die größtenteils aus Vorträgen auf zwei Arbeitstagungen im Jahre 1985 hervorgegangen sind. Die Heterogenität der behandelten Themen und verfolgten Perspektiven mag Willkür bei der Auswahl suggerieren. Sie entspricht jedoch wohl eher dem Zustand der Freizeitforschung, eines multidisziplinären Feldes, in dem sich die Verschiedenheit der fachspezifischen Ansätze mit allgemeineren paradigmatischen Gegensätzen zu hoher Heterogenität verknüpfen. So konnte nicht breiter Überblick, sondern nur exemplarische Dokumentation der Vielfalt unsere Absicht sein, wobei wir von einem breiten Begriff von Methodologie ausgegangen sind. Er umfaßt sowohl Forschungsstrategien und Probleme der Theoriebildung oder des Theoriebezugs von empirischen Untersuchungen als auch Erhebungstechniken sowie Modelle und Verfahren der Datenanalyse. Diese Breite wird hoffentlich durch die Gesamtheit der Beiträge repräsentiert, die Experten verschiedener Fachgebiete, aber auch Studierende und andere Personen mit allgemeinerem Interesse an wissenschaftlichen Methodenfragen in ihrer Arbeit oder zur Kritik anregen mögen. Wir danken der Deutschen Gesellschaft für Freizeit und dem Bundesministerium für Jugend, Familie und Gesundheit, ohne deren Unterstützung die Veranstaltung der Tagungen und das Entstehen dieses Bandes nicht möglich gewesen wäre. Besonderer Dank gebührt Frau Kornelia Funk, die das Typoskript für den Druck besorgte
    Language: German
    Keywords: Freizeitforschung ; Freizeitforschung ; Methode ; Freizeit ; Soziologie ; Aufsatzsammlung ; Aufsatzsammlung
    Author information: Agricola, Sigurd 1938-
    Author information: Lüdtke, Hartmut 1938-
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  • 4
    UID:
    gbv_310973015
    Format: S. 323-414 , Ill., graph. Darst
    Series Statement: Fresenius' journal of analytical chemistry 366,4
    Language: English
    Keywords: Analytische Chemie ; Konferenzschrift
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  • 5
    UID:
    gbv_027457087
    Format: IX, 415 S
    Note: Zugl.: Münster i. W., PH, Erziehungswiss., Diss., 1976 , Bielefeld, Pädagog. Hochsch., Diss., 1976
    Language: German
    Keywords: Hochschulschrift
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  • 6
    UID:
    gbv_1075601096
    Format: IX, 415 S. , 30 cm
    Note: Maschinenschr. vervielf , Bielefeld, Pädagog. Hochsch. Westfalen-Lippe, Diss., 1977
    Language: German
    Subjects: Sociology
    RVK:
    Keywords: Hochschulschrift
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  • 7
    UID:
    edochu_18452_27918
    Format: 1 Online-Ressource (9 Seiten)
    Content: To investigate the imaging performance of an elastin-specific molecular magnetic resonance imaging (MRI) probe with respect to the extracellular matrix (ECM) in an experimental hepatic cancer model. Twelve rabbits with hepatic VX2 tumors were examined using 3 T MRI 14, 21, and 28 days after tumor implantation for two subsequent days (gadobutrol, day 1; elastin-specific probe, day 2). The relative enhancement (RE) of segmented tumor regions (central and margin) and the peritumoral matrix was calculated using pre-contrast and delayed-phase T1w sequences. MRI measurements were correlated to histopathology and element-specific and spatially resolved mass spectrometry (MS). Mixed-model analysis was performed to assess the performance of the elastin-specific probe. In comparison to gadobutrol, the elastin probe showed significantly stronger RE, which was pronounced in the tumor margin (day 14–28: P ≤ 0.007). In addition, the elastin probe was superior in discriminating between tumor regions (χ2(4) = 65.87; P 〈 0.001). MRI-based measurements of the elastin probe significantly correlated with the ex vivo elastinstain (R = .84; P 〈0 .001) and absolute gadolinium concentrations (ICP-MS: R = .73, P 〈0 .01). LA-ICP-MS imaging confirmed the colocalization of the elastin-specific probe with elastic fibers. Elastin-specific molecular MRI is superior to non-specific gadolinium-based contrast agents in imaging the ECM of hepatic tumors and the peritumoral tissue.
    Content: Peer Reviewed
    In: London : Nature Publishing Group, 10,1
    Language: English
    URL: Volltext  (kostenfrei)
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  • 8
    UID:
    edochu_18452_25931
    Format: 1 Online-Ressource (13 Seiten)
    Content: Prostate cancer (PCa) is one of the most common cancers in men. For detection and diagnosis of PCa, non-invasive methods, including magnetic resonance imaging (MRI), can reduce the risk potential of surgical intervention. To explore the molecular characteristics of the tumor, we investigated the applicability of ferumoxytol in PCa in a xenograft mouse model in two different tumor volumes, 500 mm3 and 1000 mm3. Macrophages play a key role in tumor progression, and they are able to internalize iron-oxide particles, such as ferumoxytol. When evaluating T2*-weighted sequences on MRI, a significant decrease of signal intensity between pre- and post-contrast images for each tumor volume (n = 14; p 〈 0.001) was measured. We, furthermore, observed a higher signal loss for a tumor volume of 500 mm3 than for 1000 mm3. These findings were confirmed by histological examinations and laser ablation inductively coupled plasma-mass spectrometry. The 500 mm3 tumors had 1.5% iron content (n = 14; σ = 1.1), while the 1000 mm3 tumors contained only 0.4% iron (n = 14; σ = 0.2). In vivo MRI data demonstrated a correlation with the ex vivo data (R2 = 0.75). The results of elemental analysis by inductively coupled plasma-mass spectrometry correlated strongly with the MRI data (R2 = 0.83) (n = 4). Due to its long retention time in the blood, biodegradability, and low toxicity to patients, ferumoxytol has great potential as a contrast agent for visualization PCa.
    Content: Peer Reviewed
    In: Basel : MDPI, 14,12
    Language: English
    URL: Volltext  (kostenfrei)
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  • 9
    UID:
    edochu_18452_24779
    Format: 1 Online-Ressource (14 Seiten)
    Content: Human prostate cancer (PCa) is a type of malignancy and one of the most frequently diagnosed cancers in men. Elastin is an important component of the extracellular matrix and is involved in the structure and organization of prostate tissue. The present study examined prostate cancer in a xenograft mouse model using an elastin-specific molecular probe for magnetic resonance molecular imaging. Two different tumor sizes (500 mm3 and 1000 mm3) were compared and analyzed by MRI in vivo and histologically and analytically ex vivo. The T1-weighted sequence was used in a clinical 3-T scanner to calculate the relative contrast enhancement before and after probe administration. Our results show that the use of an elastin-specific probe enables better discrimination between tumors and surrounding healthy tissue. Furthermore, specific binding of the probe to elastin fibers was confirmed by histological examination and laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS). Smaller tumors showed significantly higher signal intensity (p 〉 0.001), which correlates with the higher proportion of elastin fibers in the histological evaluation than in larger tumors. A strong correlation was seen between relative enhancement (RE) and Elastica–van Gieson staining (R2 = 0.88). RE was related to inductively coupled plasma–mass spectrometry data for Gd and showed a correlation (R2 = 0.78). Thus, molecular MRI could become a novel quantitative tool for the early evaluation and detection of PCa.
    Content: Peer Reviewed
    In: Basel : MDPI, 10,11
    Language: English
    URL: Volltext  (kostenfrei)
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  • 10
    UID:
    edochu_18452_27909
    Format: 1 Online-Ressource (13 Seiten)
    Content: Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease with an up to 80% mortality in case of rupture. Current biomarkers fail to account for size-independent risk of rupture. By combining the information of different molecular probes, multi-target molecular MRI holds the potential to enable individual characterization of AAA. In this experimental study, we aimed to examine the feasibility of simultaneous imaging of extracellular collagen and inflammation for size-independent prediction of risk of rupture in murine AAA. The study design consisted of: (1) A outcome-based longitudinal study with imaging performed once after one week with follow-up and death as the end-point for assessment of rupture risk. (2) A week-by-week study for the characterization of AAA development with imaging after 1, 2, 3 and 4 weeks. For both studies, the animals were administered a type 1 collagen-targeted gadolinium-based probe (surrogate marker for extracellular matrix (ECM) remodeling) and an iron oxide-based probe (surrogate marker for inflammatory activity), in one imaging session. In vivo measurements of collagen and iron oxide probes showed a significant correlation with ex vivo histology (p 〈 0.001) and also corresponded well to inductively-coupled plasma-mass spectrometry and laser-ablation inductively-coupled plasma mass spectrometry. Combined evaluation of collagen-related ECM remodeling and inflammatory activity was the most accurate predictor for AAA rupture (sensitivity 80%, specificity 100%, area under the curve 0.85), being superior to information from the individual probes alone. Our study supports the feasibility of a simultaneous assessment of collagen-related extracellular matrix remodeling and inflammatory activity in a murine model of AAA.
    Content: Peer Reviewed
    In: London : Nature Publishing Group, 10,1
    Language: English
    URL: Volltext  (kostenfrei)
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