UID:
edoccha_9958125388602883
Format:
1 online resource (233 p.)
Edition:
2nd, rev. and extended ed.
ISBN:
3-318-01032-4
Series Statement:
Contributions to microbiology ; v. 11
Content:
This second, completely revised and extended edition of 〈i〉Prions: A Challenge for Science, Medicine and the Public Health System〈/i〉 is a comprehensive, up-to-date review of prions and prion-associated diseases. Leading scientists discuss the structure, molecular biology and origin of prions as well as strain variations and species barriers. Human prion diseases, prion inactivation and risks to public health are considered in detail. The new edition provides an update on basic findings of the last three years since publication of the previous edition and emphasizes practical aspects of fighting human and animal prion diseases. In addition, chapters on regulatory aspects of BSE and CJD as well as on veterinary measures have been included. A valuable single source of information on what is currently known about prions, this book will be of interest to any scientist or clinician who wants to keep up with the latest developments in this fast-moving field.
Note:
Description based upon print version of record.
,
""Contents""; ""Dedication in Remembrance of Andreas Scheid (1941�2001)""; ""Note of the Series Editor""; ""Preface to the Second Edition""; ""Preface to the First Edition""; ""Transmissible Spongiform Encephalopathies: The Prion Theory � Background and Basic Information""; ""Non-Virus Properties of the Scrapie Agent""; ""The Concept of Two Isoforms of the Prion Protein""; ""Basic Experiments Pro and Contra Prions""; ""The Search for a Nucleic Acid""; ""Structural Transitions of the Prion Protein as Basis for the Replication Mechanism""
,
""Infectious, Sporadic and Familial Etiology of Prion Diseases Based on the Prion Model""""Outlook""; ""Acknowledgment""; ""References""; ""Structural Biology of Prions""; ""The Primary Structure of the Prion Protein""; ""The Neurotoxic Model Peptide, PrP106�126""; ""Metal-Binding Domains of the Prion Protein""; ""Secondary Structure Analysis of the Prion Protein""; ""Tertiary Structure of the Normal Prion Protein (PrPC)""; ""Influence of Familial Mutations on the Structure of the Prion Protein""; ""Tertiary Structure of the Infectious Prion Protein (PrP TSE )""
,
""Deciphering the Structure of Infectious Prion Protein with Antibodies""""Prion Protein Folding Pathways and Their Conformational Properties""; ""Conclusion""; ""References""; ""Prion Strains and Species Barriers""; ""Prion Strains""; ""Molecular Basis of Prion Strains""; ""Species Barriers""; ""Subclinical Prion Infection""; ""Implications of Prion Disease vs. Prion Infection""; ""Re-Evaluating Prion Strains and Species Barriers""; ""Acknowledgement""; ""References""; ""Prions of Saccharomyces and Podospora""; ""Three Genetic Criteria for Prions""; ""[URE3] as a Prion of the Ure2 Protein""
,
""Structure of Ure2p""""Aggregation of Ure2p in vivo and in vitro""; ""[PSI] as a Prion of the Sup35 Protein""; ""Interaction with Other Proteins in the Cell and Influence of Chaperones""; ""Prion Variants""; ""Other Prions in Saccharomyces cerevisiae""; ""[Het-s], a Prion with a Normal Cellular Function""; ""Are in vitro Produced Filaments Infectious?""; ""Acknowledgement""; ""References""; ""Human Prion Diseases: Cause, Clinical and Diagnostic Aspects""; ""Creutzfeldt-Jakob Disease""; ""Sporadic CJD (spCJD)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""
,
""Epidemiology and Risk Factors of Transmissible Spongiform Encephalopathies in Man""
,
English
Additional Edition:
ISBN 1-4175-2256-9
Additional Edition:
ISBN 3-8055-7656-0
Language:
English
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