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Berlin Brandenburg

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  • 1
    Language: English
    In: The American journal of psychiatry, June 1993, Vol.150(6), pp.972-4
    Description: Test-retest interviews examining recent sexual activity were administered to 27 severely ill psychiatric patients after stabilization. Three reports were judged to be questionable. For the 16 sexually active patients among the remaining 24, high test-retest reliability was found for number of sexual partners, frequency of episodes, and proportions of episodes involving vaginal intercourse and use of condoms. The interviews did not exacerbate psychiatric symptoms.
    Keywords: Risk-Taking ; Sexual Behavior ; Acquired Immunodeficiency Syndrome -- Transmission ; Mental Disorders -- Diagnosis ; Psychiatric Status Rating Scales -- Standards
    ISSN: 0002-953X
    E-ISSN: 15357228
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  • 2
    Language: English
    In: The American journal of psychiatry, February 1982, Vol.139(2), pp.240-1
    Keywords: Blood Platelets -- Enzymology ; Monoamine Oxidase -- Blood ; Schizophrenia -- Enzymology
    ISSN: 0002-953X
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 3
    Language: English
    In: The American journal of psychiatry, June 1985, Vol.142(6), pp.697-701
    Description: The authors assessed the relevance of narrowly defined diagnostic criteria to genetic research in schizophrenia in the nuclear families of 84 chronic schizophrenic probands compared with families of 90 normal control probands. The morbidity risk for narrowly defined schizophrenia in first-degree relatives of patients with the narrow diagnosis was significantly higher than the control rate (3.8% versus 0.3%). The rate of chronic schizophrenia in the relatives of all schizophrenic patients was also significantly higher than the control rate (7.1% versus 0.6%), as was the rate of "spectrum" disorders (33.4% versus 11.3%). The data support the case for familial transmission of narrowly defined schizophrenia.
    Keywords: Schizophrenia -- Genetics
    ISSN: 0002-953X
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 4
    Language: English
    In: The American journal of psychiatry, July 1984, Vol.141(7), pp.836-42
    Description: Platelet monoamine oxidase (MAO) activity, determined in 102 patients with chronic schizophrenia, 223 first-degree relatives, and 88 normal control subjects, was shown to be a heritable and stable trait and was significantly lower in patients than in normal control subjects. Within families, MAO activity distinguished ill from well relatives. However, the considerable overlap in enzyme activity between affected and unaffected individuals limits the usefulness of low MAO activity as a major risk factor in schizophrenia.
    Keywords: Blood Platelets -- Enzymology ; Monoamine Oxidase -- Metabolism ; Schizophrenia -- Genetics
    ISSN: 0002-953X
    E-ISSN: 15357228
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  • 5
    Language: English
    In: The American journal of psychiatry, January 1984, Vol.141(1), pp.29-32
    Description: The authors determined the erythrocyte catechol O-methyltransferase (COMT) activity of 38 chronic schizophrenic patients, 69 of their first-degree relatives, and 39 normal controls. COMT activity did not distinguish patients from controls. Within families, COMT activity was not associated with schizophrenia spectrum disorders. The data suggest that COMT activity is not an indicator of vulnerability to schizophrenia.
    Keywords: Catechol O-Methyltransferase -- Blood ; Erythrocytes -- Enzymology ; Schizophrenia -- Genetics
    ISSN: 0002-953X
    E-ISSN: 15357228
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  • 6
    Language: English
    In: The American journal of psychiatry, November 1983, Vol.140(11), pp.1437-42
    Description: The types and expectancy of mental disorders in the siblings of 74 probands with chronic schizophrenia were examined. The siblings were classified according to whether 1) both parents had schizotypal personality disorder, 2) one parent had the disorder and one was normal, or 3) both parents were normal. Siblings whose parents both had the disorder were at significantly greater risk for schizophrenia and schizotypal personality disorder than siblings with at least one normal parent. Similarly, the expectancy of schizotypal personality disorder alone and combined with schizophrenia was higher among siblings with one parent with the disorder than in siblings with two normal parents. The data suggest that schizotypal traits may be genetically related to schizophrenia.
    Keywords: Family ; Schizophrenia -- Genetics ; Schizotypal Personality Disorder -- Genetics
    ISSN: 0002-953X
    E-ISSN: 15357228
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  • 7
    Language: English
    In: The American journal of psychiatry, August 1985, Vol.142(8), pp.972-3
    Description: Among 76 chronic schizophrenic patients, plasma amine oxidase activity was unrelated to paranoid/nonparanoid subtype, narrow/broad diagnostic criteria, prognosis, or age at onset. These clinical indices do not identify biological subtypes of schizophrenia with deviant plasma amine oxidase activity.
    Keywords: Amine Oxidase (Copper-Containing) ; Oxidoreductases Acting on Ch-Nh Group Donors -- Blood ; Schizophrenia -- Diagnosis
    ISSN: 0002-953X
    E-ISSN: 15357228
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  • 8
    Language: English
    In: The American journal of psychiatry, August 1985, Vol.142(8), pp.927-34
    Description: The authors determined the risk for psychiatric disorders in the first-degree relatives of 36 probands with schizotypal personality disorder (13 definite, 23 probable), 17 probands with borderline personality disorder (two definite, 15 probable), and 90 normal control probands. The relatives of probands with schizotypal personality disorder without a concurrent diagnosis of borderline personality disorder had a significantly greater risk for schizotypal personality disorder than the relatives of normal control probands, borderline probands, or schizotypal probands with coexisting borderline personality disorder. The relatives of borderline probands had a significantly greater risk for definite and probable borderline personality disorder than the relatives of normal control probands.
    Keywords: Borderline Personality Disorder -- Genetics ; Personality Disorders -- Genetics ; Schizotypal Personality Disorder -- Genetics
    ISSN: 0002-953X
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 9
    Language: English
    In: The American journal of psychiatry, April 1985, Vol.142(4), pp.447-55
    Description: Morbidity risks for mental illness were determined in 750 first-degree relatives of chronic schizophrenic and normal control probands. Psychiatric disorders that were more frequent in relatives of schizophrenic probands than in relatives of normal control probands were chronic schizophrenia (5.8% versus 0.6%), schizotypal personality disorder (definite, 14.6% versus 2.1%; probable, 12.1% versus 6.5%), and paranoid personality disorder (7.3% versus 2.3%). The data suggest that schizotypal and paranoid personality disorders are genetically related to schizophrenia. The implications for schizophrenia research are discussed.
    Keywords: Schizophrenia -- Genetics
    ISSN: 0002-953X
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 10
    Language: English
    In: The American journal of psychiatry, June 1986, Vol.143(6), pp.711-7
    Description: Platelet [3H]imipramine binding (Bmax) was determined in 67 patients with major affective illness (33 euthymic bipolar, 34 depressed unipolar) and 58 normal control subjects. Bipolar patients had significantly lower Bmax values than did control subjects. The mean Bmax in the unipolar patients was lower than in the control subjects, but the difference was not statistically significant. Dissociation constant (Kd) values did not distinguish patients in either category from control subjects. The significantly lower Bmax in euthymic bipolar patients and the apparent state independence of Bmax in some but not all unipolar patients suggest that platelet imipramine binding may be a trait marker in a subset of affective disorders.
    Keywords: Bipolar Disorder -- Blood ; Depressive Disorder -- Blood ; Imipramine -- Blood
    ISSN: 0002-953X
    E-ISSN: 15357228
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