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  • 1
    Language: English
    In: Analytica Chimica Acta, 28 September 2016, Vol.938, pp.106-113
    Description: Limited drug penetration into tumor tissue is a significant factor to the effectiveness of cancer therapy. Tumor spheroids, a 3D cell culture model system, can be used to study drug penetration for pharmaceutical development. In this study, a method for quantitative bioimaging of platinum group elements by laser ablation (LA) coupled to inductively coupled plasma mass spectrometry (ICP-MS) is presented. Different matrix-matched standards were used to develop a quantitative LA-ICP-MS method with high spatial resolution. To investigate drug penetration, tumor spheroids were incubated with platinum complexes (Pt(II)acetylacetonate, cisplatin) and the palladium tagged photosensitizer 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin ( THPP). Distribution and accumulation of the pharmaceuticals were determined with the developed method.
    Keywords: La-Icp-MS ; Quantification ; Tumor Spheroids ; Pt Cytostatics ; Photosensitizer ; Chemistry
    ISSN: 0003-2670
    E-ISSN: 1873-4324
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  • 2
    Language: English
    In: Analytica Chimica Acta, 1995, Vol.305(1), pp.154-158
    Description: A direct adsorptive stripping voltammetric (AdSV) procedure was used for the determination of ultratrace concentrations of uranium(VI) as its uranium-chloranilic acid complex (2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone). The calculated detection limit was 24 ng per litre. This method was easily applied to the analysis of natural water and uranium slag heap leachate with no sample pretreatment. The obtained results were compared with those found using different reference methods. Organic surfactants (such as Triton X-100) had low influence on the results. This was explained by alternating current (of the first harmonic wave, AC1) voltammetric investigations. The potential at which the adsorption peak occurred, due to the complex of uranium with chloranilic acid, was identical with the optimal accumulation potential.
    Keywords: Stripping Voltammetry ; Uranium ; Chemistry
    ISSN: 0003-2670
    E-ISSN: 1873-4324
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  • 3
    Language: English
    In: Analytica Chimica Acta, 1997, Vol.349(1), pp.93-99
    Description: The paper describes the development of two different techniques for the automated determination of uranium by adsorptive stripping voltammetry (AdSV). As a complex forming reagent 2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone (chloranilic acid) is used. The automation was performed in one case using an auto-batch system and in the second case by means of a flow-through cell. Sensitivities, reproducibilities and the fields of application are evaluated. The auto-batch technique, with the automatic standard addition capability as well as its logical decision-making capacity for selecting the correct type of working electrode makes it highly suitable for the determination of varying uranium concentrations above 1 μg/l. The dilution of the sample, required by the methodology, makes determinations of uranium concentrations less than 1 mg/l unattainable. The flow-through technique is more suited to determine uranium at the ultra trace concentration level (above 70 ng/l). Provided the matrix is reasonably constant, a pre-determined calibration curve can be used and, due to the higher slope of the calibration plot in the flow-through technique, the linear concentration range extends to a lower concentration compared to stationary conditions. Another advantage of the flow-through technique is the possibility of kinetic and mechanistic investigations of AdSV procedures.
    Keywords: Stripping Voltammetry ; Uranium Traces ; Waters ; Chemistry
    ISSN: 0003-2670
    E-ISSN: 1873-4324
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