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Berlin Brandenburg

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  • 1
    Language: English
    In: Archives of general psychiatry, October 1978, Vol.35(10), pp.1222-7
    Description: It has been suggested that, if dopamine antagonism is a necessary condition for the antischizophrenic action of neuroleptics, the prolactin response, as an index of dopamine blockade, would correlate with clinical response. Morning prolactin and clinical symptomatology were measured in 15 schizophrenic patients before neuroleptic therapy, and after three and six weeks of high-dose butaperazine or loxapine treatment. Prolactin levels were transiently elevated during the unmedicated admission period, probably reflecting a normal stress response. Prolactin increased in all patients during neuroleptic therapy. There was, however, no correlation between magnitude of prolactin changes and clinical response, probably because the prolactin response achieved a maximum at relatively low doses of neuroleptics.
    Keywords: Dibenzoxazepines -- Therapeutic Use ; Loxapine -- Therapeutic Use ; Phenothiazines -- Therapeutic Use ; Prolactin -- Blood ; Schizophrenia -- Drug Therapy
    ISSN: 0003-990X
    E-ISSN: 15383636
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  • 2
    Language: English
    In: Archives of general psychiatry, March 1983, Vol.40(3), pp.275-9
    Description: Plasma amine oxidase (PAO) activity was studied in 52 chronic schizophrenics, 130 first-degree relatives, and 36 normal control subjects. Enzyme activity was shown to be a heritable and stable characteristic. Age and sex effects were not present. Patients had lower PAO activity than did control subjects, although the difference fell short of statistical significance. Within families, reduced PAO activity was associated with schizophrenia spectrum disorders.
    Keywords: Amine Oxidase (Copper-Containing) ; Oxidoreductases Acting on Ch-Nh Group Donors -- Blood ; Schizophrenia -- Genetics
    ISSN: 0003-990X
    E-ISSN: 15383636
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  • 3
    Language: English
    In: Archives of general psychiatry, July 1975, Vol.32(7), pp.885-6
    Description: Thioridazine, unlike most other effective antipsychotic drugs, appears to be only a weak dopamine antagonist in various regions of the brain. We decided to test, indirectly, thioridazine's effects on another brain dopaminergic system, the tuberoinfundibular tract, which regulates prolactin secretion by stimulating hypothalamic secretion of prolactin-inhibiting factor. Chlorpromazine and several other phenothiazines have been shown to stimulate prolactin secretion. Five healthy men ingested 50 mg of chlorpromazine concentrate on one occasion, and 50 mg of thioridazine concentrate on another. Both drugs noticeably stimulated prolactin secretion within two hours. It is concluded that thioridazine is a potent dopamine antagonist in the tuberoinfundibular system, and it is suggested that this system's regulation of prolactin secretion may provide a useful method for studying antipsychotic drug effects in man.
    Keywords: Hypothalamus -- Drug Effects ; Prolactin -- Metabolism ; Thioridazine -- Pharmacology
    ISSN: 0003-990X
    E-ISSN: 15383636
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  • 4
    Language: English
    In: Archives of general psychiatry, April 1975, Vol.32(4), pp.502-3
    Description: After ingestion of 500 mg of levodopa, postmenopausal women had significantly diminished human growth hormone (HGH) responses (mean, 4.6 ng/ml), as compared with those of age-matched men (mean, 9.1 ng/ml; P smaller than .05). The differences between the groups were not related to plasma dopa concentrations. The HGH responses to levodopa of age-matched unipolar and bipolar depressed men, and of unipolar depressed postmenopausal women, did not differ significantly from their respective normal control groups. Depressive illness of these types does not appear to affect the HGH response to levodopa, once the effect of the menopause is taken into account.
    Keywords: Menopause ; Depression -- Physiopathology ; Dihydroxyphenylalanine -- Blood ; Growth Hormone -- Metabolism ; Levodopa -- Pharmacology ; Pituitary Gland -- Metabolism
    ISSN: 0003-990X
    E-ISSN: 15383636
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