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  • 1
    Language: English
    In: Biochemical and Biophysical Research Communications, 23 March 2012, Vol.419(4), pp.698-702
    Description: ► Characterization of the proliferating cell nuclear antigen in (TbPCNA). ► TbPCNA is a suitable marker to detect replication in . ► TbPCNA distribution and regulation is different compared to closely related parasites and . As in most eukaryotic cells, replication is regulated by a conserved group of proteins in the early-diverged parasite . Only a few components of the replication machinery have been described in this parasite and regulation, sub-nuclear localization and timing of replication are not well understood. We characterized the proliferating cell nuclear antigen in (TbPCNA) to establish a spatial and temporal marker for replication. Interestingly, PCNA distribution and regulation is different compared to the closely related parasites and . TbPCNA foci are clearly detectable during S phase of the cell cycle but in contrast to they are not preferentially located at the nuclear periphery. Furthermore, PCNA seems to be degraded when cells enter G2 phase in suggesting different modes of replication regulation or functions of PCNA in these closely related eukaryotes.
    Keywords: Pcna ; Replication ; S Phase Marker ; Cell Cycle Regulation ; Trypanosoma Brucei ; Biology ; Chemistry ; Anatomy & Physiology
    ISSN: 0006-291X
    E-ISSN: 1090-2104
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  • 2
    Language: English
    In: Biochemical and Biophysical Research Communications, 2008, Vol.368(4), pp.846-851
    Description: Some inroads have been made into characterizing histone variants and post translational modifications of histones in . Histone variant H2BV lysine 129 is homologous to H2B lysine 123, whose ubiquitination is required for methylation of H3 lysines 4 and 79. We show that H2BV K129 is not ubiquitinated, but trimethylation of H3 K4 and K76, homologs of H3 K4 and K79 in yeast, was enriched in nucleosomes containing H2BV. Mutation of H2BV K129 to alanine or arginine did not disrupt H3 K4 or K76 methylation. These data suggest that H3 K4 and K76 methylation in trypanosomes is regulated by a novel mechanism, possibly involving the replacement of H2B with H2BV in the nucleosome.
    Keywords: Chromatin Structure ; Histone Methylation ; Histone Modification ; Histone Ubiquitination ; Histone Variant ; Mass Spectrometry ; Nucleosome ; Trypanosoma Brucei ; Biology ; Chemistry ; Anatomy & Physiology
    ISSN: 0006-291X
    E-ISSN: 1090-2104
    Library Location Call Number Volume/Issue/Year Availability
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