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  • British journal of clinical pharmacology
  • 1
    Language: English
    In: British Journal of Clinical Pharmacology, 03/1980, Vol.9(3), pp.300P-301P
    Keywords: Pharmacy, Therapeutics, & Pharmacology;
    ISSN: British Journal of Clinical Pharmacology
    E-ISSN: 03065251
    E-ISSN: 13652125
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    In: British Journal of Clinical Pharmacology, March 1980, Vol.9(3), pp.300P-301P
    ISSN: 0306-5251
    E-ISSN: 1365-2125
    Source: John Wiley & Sons, Inc.
    Library Location Call Number Volume/Issue/Year Availability
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  • 3
    In: British Journal of Clinical Pharmacology, May 1982, Vol.13(5), pp.711-716
    Description: 1 Prizidilol hydrochloride (SK&F 92657) is a new compound which causes both arteriolar dilatation and beta‐adrenoceptor blockade. The effect of a single oral dose on the responses of heart rate and blood pressure to isoprenaline infusion has been studied in healthy volunteers. 2 Isoprenaline heart rate dose‐response curves showed parallel shifts to the right after oral prizidilol, indicating antagonism by this compound at beta‐adrenoceptors in the heart. 3 Isoprenaline dose‐response curves for decreases in diastolic blood pressure also showed shifts to the right after oral prizidilol, providing evidence of beta‐adrenoceptor antagonism by this drug in peripheral resistance vessels. 4 The peak effect of a 40 mg dose of propranolol was greater than that of a 200 mg dose of prizidilol but both drugs caused persistent beta‐adrenoceptor blockade for at least 7 h after ingestion.
    Keywords: Pharmacy, Therapeutics, & Pharmacology;
    ISSN: 0306-5251
    E-ISSN: 1365-2125
    Library Location Call Number Volume/Issue/Year Availability
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