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  • 1
    Language: English
    In: EBioMedicine, September 2016, Vol.11, pp.85-90
    Description: Recently, the World Health Organization launched a campaign to eradicate the tropical disease yaws, caused by the bacterium subsp. ; however, for decades researchers have questioned whether flies act as a vector for the pathogen that could facilitate transmission. A total of 207 fly specimens were trapped in areas of Africa in which . -induced skin ulcerations are common in wild baboons; 88 flies from Tarangire National Park and 119 from Lake Manyara National Park in Tanzania were analyzed by PCR for the presence of . DNA. We report that in the two study areas, . DNA was found in 17–24% of wild-caught flies of the order Diptera. Treponemal DNA sequences obtained from many of the flies match sequences derived from nearby baboon . strains, and one of the fly species with an especially high prevalence of . DNA, , has previously been shown to transmit yaws in an experimental setting. Our results raise the possibility that flies play a role in yaws transmission; further research is warranted, given how important understanding transmission is for the eradication of this disfiguring disease. The discovery of DNA on necrophagous flies in Africa supports historical reports on possible transmission of the bacterium by flies as a mechanical vector. The bacterium (subsp. ) causes human yaws, which is currently subject to eradication efforts. It has been shown that African nonhuman primates are also found to be infected with . strains that are closely related to human yaws causing strains. The ecology of . infection in primates is not yet fully understood and intra- and interspecies transmission pathways, apart from skin-to-skin contact in humans, are largely unknown.
    Keywords: Treponema Pallidum ; Dipteria ; Yaws ; Nonhuman Primates ; Transmission ; Biology
    ISSN: 2352-3964
    E-ISSN: 2352-3964
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