Kooperativer Bibliotheksverbund

Berlin Brandenburg

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  • 1
    Language: English
    In: International urogynecology journal, December 2018, Vol.29(12), pp.1797-1805
    Description: Women have a 20% risk of developing a urinary tract infection (UTI) following urogynecologic surgery. This study assessed the association of postoperative UTI with bacteria in preoperative samples of catheterized urine. Immediately before surgery, vaginal swabs, perineal swabs, and catheterized urine samples were collected, and the V4 region of the 16S ribosomal RNA (rRNA) gene was sequenced. The cohort was dichotomized in two ways: (1) standard day-of-surgery urine culture result (positive/negative), and (2) occurrence of postoperative UTI (positive/negative). Characteristics of bladder, vaginal, and perineal microbiomes were assessed to identify factors associated with postoperative UTI. Eighty-seven percent of the 104 surgical patients with pelvic organ prolapse/urinary incontinence (POP/UI) were white; mean age was 57 years. The most common genus was Lactobacillus, with a mean relative abundance of 39.91% in catheterized urine, 53.88% in vaginal swabs, and 30.28% in perineal swabs. Two distinct clusters, based on dispersion of catheterized urine (i.e., bladder) microbiomes, had highly significant (p 〈 2.2-16) differences in age, microbes, and postoperative UTI risk. Postoperative UTI was most frequently associated with the bladder microbiome; microbes in adjacent pelvic floor niches also contributed to UTI risk. UTI risk was associated with depletion of Lactobacillus iners and enrichment of a diverse mixture of uropathogens. Postoperative UTI risk appears to be associated with preoperative bladder microbiome composition, where an abundance of L. iners appears to protect against postoperative UTI.
    Keywords: Postoperative Infection ; Surgical Infection ; Urinary Tract Infection ; Urobiome ; Gynecologic Surgical Procedures ; Microbiota ; Postoperative Complications -- Microbiology ; Urinary Tract Infections -- Microbiology
    ISSN: 09373462
    E-ISSN: 1433-3023
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  • 2
    Language: English
    In: International urogynecology journal, December 2018, Vol.29(12), pp.1765-1771
    Description: Persistent and de novo symptoms decrease satisfaction after urogynecologic surgery. We investigated whether the preoperative bladder microbiome is associated with urinary symptoms prior to and after urogynecologic surgery. One hundred twenty-six participants contributed responses to the validated OABq symptom questionnaire. Catheterized (bladder) urine samples and vaginal and perineal swabs were collected immediately preoperatively. Bacterial DNA in the urine samples and swabs was sequenced and classified. Preoperative symptom severity was significantly worse in sequence-positive patients. Higher OABq Symptom Severity (OABqSS) scores (more symptomatic) were associated with higher abundance in bladder urine of two bacterial species: Atopobium vaginae and Finegoldia magna. The presence of Atopobium vaginae... Two specific bacterial species detected in bladder urine, Atopobium vaginae and Finegoldia magna, are associated with preoperative urinary symptom severity in women undergoing POP/SUI surgery. The reservoir for Atopobium vaginae may be adjacent pelvic floor niches. This observation should be validated...
    Keywords: Bladder ; Microbiome ; Urinary Incontinence ; Urinary Symptoms ; Gynecologic Surgical Procedures -- Adverse Effects ; Postoperative Complications -- Microbiology ; Urine -- Microbiology
    ISSN: 09373462
    E-ISSN: 1433-3023
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  • 3
    Language: English
    In: International Urogynecology Journal, 2018, Vol.29(12), pp.1765-1771
    Keywords: Microbiome ; Urinary incontinence ; Bladder ; Urinary symptoms
    ISSN: 0937-3462
    E-ISSN: 1433-3023
    Source: Springer Science & Business Media B.V.
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  • 4
    Language: English
    In: International Urogynecology Journal, 2018, Vol.29(12), pp.1797-1805
    Keywords: Urinary tract infection ; Urobiome ; Surgical infection ; Postoperative infection
    ISSN: 0937-3462
    E-ISSN: 1433-3023
    Source: Springer Science & Business Media B.V.
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  • 5
    Language: English
    In: International Urogynecology Journal, 2019, Vol.30(8), pp.1261-1267
    Description: INTRODUCTION AND HYPOTHESISPresence of microbial communities (microbiota) in an organ system depends on environmental factors, such as oxygen availability. We describe a novel technique to measure bladder urine oxygen tension (BUOT) in ambulatory women and use that technique to compare BUOT values to female urinary microbiota and participant urinary signs and symptoms. METHODSAmbulatory female urogynecology patients presenting for clinical care who were willing to undergo transurethral catheterization underwent BUOT determination with a non-invasive flow-through oxygen sensor. To detect urinary microbiota in the bladder, 16S rRNA gene sequencing was performed on catheterized urine. Multivariate statistical analyses were performed to examine potential correlations among BUOT, urinary microbiota compositions and clinical variables. RESULTSSignificant variation in BUOT existed between individuals (range: 0.47-51.5 mmHg; median: 23.1 ± 13.5). Microbiota compositions were associated with BUOT (p = 0.03). BUOT was significantly lower in urines that were nitrite negative on dipstick analysis (p = 0.0001) and in participants who answered yes to having urinary leakage on the validated Urinary Distress Inventory (p = 0.01). CONCLUSIONSBUOTs can be measured in ambulatory women. For urogynecology patients, a wide range of values exist. BUOT may be associated with the presence of urinary microbiota and resultant signs and symptoms.
    Keywords: Human microbiome ; Urinary bladder ; Oxygen tension
    ISSN: 0937-3462
    E-ISSN: 1433-3023
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