Kooperativer Bibliotheksverbund

Berlin Brandenburg

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  • 1
    Language: English
    In: Journal of Drug Targeting, 01 January 1995, Vol.3(3), pp.171-173
    Description: Albert Einstein reportedly once said that the arts and sciences are merely different branches of the same tree. Indeed, the arts often inspire the creation of scientific ideas and concepts. In the case of drug targeting, it was either...
    Keywords: Pharmacy, Therapeutics, & Pharmacology
    ISSN: 1061-186X
    E-ISSN: 1029-2330
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  • 2
    Language: English
    In: Journal of Drug Targeting, 01 January 1993, Vol.1(1), pp.15-19
    Description: Radiolabelled poly(methylmethacrylate) (PMMA) nanoparticles were coated with rat serum albumin (RSA), serum and inactivated serum, to examine the influence of these blood components on the body distribution of a model colloidal drug carrier. The particles were incubated overnight at 37°C either in a 1% solution of RSA in phosphate buffered saline (PBS) or in serum obtained from the rats. A suspension of nanoparticles in PBS was used as a control. Serum complement inactivation was achieved by storage at 56°C for 30min. The suspensions were then injected intravenously via the tail vein of Wistar rats. The animals were sacrificed at five different time points (30min, 2h, 6h, 24 h, and 7 d after injection) and two samples of each organ and two blood samples were weighed into scintillation vials. The radioactivity of each sample was then measured in a Beckman scintillation counter. Coating with RSA led to no significant change in the body distribution of the particles, whereas incubation in serum, especially with complement inactivation prior to injection, very significantly reduced the uptake of particles into the organs of the reticuloendothelial system (RES), e.g., liver, spleen, and bone marrow. At the same time, much higher concentrations of nanoparticles were observed in the serum and in non-RES organs and peripheral tissues (kidneys, muscles, and intestine). This effect was most pronounced after 30min, but was still observable after 7d.
    Keywords: Body Distribution ; Pmma Nanoparticles ; Opsonization ; Serum Components ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 1061-186X
    E-ISSN: 1029-2330
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  • 3
    Language: English
    In: Journal of Drug Targeting, 01 January 2001, Vol.9(3), pp.209-221
    Description: Poly(butylcyanoacrylate) nanoparticles were produced by emulsion polymerisation and used either uncoated or overcoated with polysorbate 80 (Tween® 80). [ 3 H]-dalargin bound to nanoparticles overcoated with polysorbate 80 or in the form of saline solution...
    Keywords: Nanoparticles ; Blood-Brain Barrier ; Drug Delivery ; Dalargin ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 1061-186X
    E-ISSN: 1029-2330
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  • 4
    Language: English
    In: Journal of Drug Targeting, 01 January 1998, Vol.5(3), pp.171-179
    Description: The objective of the present study is to visualize differences in the body distribution between radiolabeled AZT bound to nanoparticles and a control solution. Polyhexylcyanoacrylate nanoparticles were manufactured by emulsion polymerization in the presence of AZT and an ionic emulsifier, bis(2-ethylhexyl)...
    Keywords: Azidothymidine ; AZT ; Anoparticles ; Body Distribution ; Autoradiography ; Radioluminography ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 1061-186X
    E-ISSN: 1029-2330
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  • 5
    Language: English
    In: Journal of Drug Targeting, 01 January 1999, Vol.6(5), pp.373-385
    Description: The rapid reticuloendothelial system (RES) uptake of nanoparticles after i.v. injection, especially by the liver, can be reduced and the body distribution can be altered by coating them with non-ionic surfactants. In the present work 2- 14 C-poly(methyl...
    Keywords: Drug Targeting ; Poly(Methyl Methacrylate) ; Nanoparticles ; Surfactant Coating ; Body Distribution ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 1061-186X
    E-ISSN: 1029-2330
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  • 6
    Language: English
    In: Journal of Drug Targeting, 01 January 1994, Vol.2(1), pp.61-77
    Description: Silica nanoparticles, radiolabeled with 75 Selenium were coated with 14 types of ω-functionalized surfactants covalently bound to the particle surface. The particles were suspended in phosphate buffered saline (PBS) and injected intravenously via the tail vein of Wistar rats. The animals were sacrificed after 5 different time points (30 min, 2 h, 6 h, 24 h, and 7 d), and two samples of each organ and two blood samples were weighed into vials. The radioactivity of each sample was measured in a LKB-Wallac CliniGamma counter. Coated silica nanoparticles accumulated in the liver at much lower levels than other colloidal drug carriers after short time periods (30 min). The liver accumulation increased after longer time periods due to a natural redistribution process. Surface modification by increasing the hydrophilicity and thickness of coating yielded higher and longer persisting concentrations in the intestine, blood, and the muscles. Initially increased lung concentrations were decreasing with time, propably due to migration of the alveolar phagocytes.
    Keywords: Body Distribution ; Silica Nanoparticles ; Reticuloendothelial System ; Covalent Particle Coating ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 1061-186X
    E-ISSN: 1029-2330
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  • 7
    Language: English
    In: Journal of drug targeting, 1998, Vol.6(4), pp.293-307
    Description: Biodegradable 14C-poly(D,L-lactic acid) (PLA50) nanoparticles coated either with a readily digestible protein albumin or with a non-digestible coating agent, polyvinyl alcohol (PVA), were prepared by the solvent evaporation technique. The nanoparticles were administered perorally to guinea pigs to evaluate the gastro-intestinal degradation of their PLA50 matrix. In the case of PLA50 nanoparticles coated with digestible albumin, substantial gastro-intestinal degradation of the PLA50 matrix occurred, leading to the passage of considerable amount (〉 or =45%) of water-soluble products across the gastrointestinal barrier. When a non-digestible coating agent like PVA was used, the degradation of the PLA50 matrix in the gastro-intestinal tract was at least two times lower (〉 or =19%). The results show that it is possible to control the in vivo degradation of PLA50 nanoparticles using appropriate coating agents. The present investigations showed a good correlation between previously observed in vitro results and the in vivo findings.
    Keywords: Polyvinyl Alcohol ; Serum Albumin ; Lactic Acid -- Pharmacokinetics ; Polymers -- Pharmacokinetics
    ISSN: 1061-186X
    E-ISSN: 10292330
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  • 8
    Language: English
    In: Journal of drug targeting, 1993, Vol.1(1), pp.21-7
    Description: Peroral nanoparticle-mediated drug absorption was studied using a laser scanning confocal microscope. Additional diffusion studies in side-by-side diffusion cells with radiolabelled polybutylcyanoacrylate (PBCA) nanoparticles were carried out to confirm the results of this study. Fluorescence-labelled PBCA nanoparticles were incubated in vitro in the lumen of freshly excised intestine. Computer-aided optical sectioning of thick samples with dramatically improved resolution and the possibility of rejecting out-of-focus noise enabled tracking of the fluorescence-labelled PBCA nanoparticles in the intestinal tissue after incubation of the particles in freshly excised porcine small intestine. The results of this study suggest that the nanoparticles are absorbed by the surface of the gut wall, creating a high concentration gradient, thereby enhancing the absorption of drugs that may be loaded to the nanoparticles. A significant amount of particles was found in hot (very fluorescent) spots that were assumed to be Peyer's patches. No particles, however, traversed the entire gut wall over a period of 2 to 4 h. These results were confirmed by the diffusion study. No radioactivity permeated through Peyer's-patch-free intestine within 4 h, whereas the amount of radioactivity that was transported through intestine with Peyer's patches during this time was 1.1% of the total amount in the donor chamber.
    Keywords: Intestinal Absorption ; Microspheres
    ISSN: 1061-186X
    E-ISSN: 10292330
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  • 9
    Language: English
    In: Journal of Drug Targeting, 01 January 2006, Vol.14(2), pp.97-105
    Description: It was recently shown that doxorubicin (DOX) bound to polysorbate-coated nanoparticles (NP) crossed the intact blood-brain barrier (BBB), and thus reached therapeutic concentrations in the brain. Here, we investigated the biodistribution in...
    Keywords: Blood-Brain Barrier ; Glioblastoma ; Nanoparticles ; Doxorubicin ; Polysorbate 80 ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 1061-186X
    E-ISSN: 1029-2330
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