Journal of Hepatology, December 2011, Vol.55(6), pp.1201-1206
The mutation has been suspected to adversely affect outcomes of HCV infection, although reports have remained controversial. Here, we investigated the relative genetic contributions of the 32 deletion and the rs12979860 polymorphisms to spontaneous clearance of hepatitis C in a single-source outbreak. We retrieved 396 Caucasian women (119 women with spontaneous HCV clearance) who had been infected with HCV genotype 1-contaminated anti-D immunoglobulin in 1978, and determined their and alleles. CC, CT, and TT genotypes were found in 35.4%, 50%, and 14.6% of patients and corresponded to spontaneous clearance rates of 50%, 21.2%, and 12.1% (Chi = 38.7, = 5.0 × 10 ), respectively. WT/WT, WT/Δ32, and Δ32/Δ32 genotypes were observed in 76%, 22.7%, and 1.3% of patients and corresponded to clearance rates of 33.2%, 21.2%, and 0% (Chi = 6.9, = 0.009), respectively. In a stepwise forward-conditional multivariate regression model both (OR 2.1, = 0.01 for WT/WT) and genetic variants (OR 4.3, = 4.6 × 10 for the C/C genotype) were identified as independent predictors of spontaneous HCV clearance. Importantly, favorable response rates were associated with the CC genotype only in wild-type homozygous women, while HCV clearance in carriers remained poor even in patients with the rs12979860 CC genotype. Both rs1297860 and allelic variants are independent genetic determinants of spontaneous HCV clearance. The variable relative distribution between rs1297860 and allelic variants in different populations may have masked the role of the mutation in some studies.
Hepatitis C Virus ; Il28b ; Ccr5 ; Polymorphism ; Clearance ; Anti-D Cohort ; Medicine
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