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  • Journal of natural products  (86)
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  • 1
    Language: English
    In: Journal of natural products, 27 May 2011, Vol.74(5), pp.1132-41
    Description: Six new withanolides, paraminabeolides A-F (1-6), along with five known compounds, minabeolides-1, -2, -4, -5, and -8 (7-11), were isolated from a Formosan soft coral, Paraminabea acronocephala. The structures of these compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The absolute configuration of 4 was determined by the application of Mosher's method. Compounds 1 and 7 were cytotoxic toward Hep G2 cancer cells. Compounds 1-4 and 7-10 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein. Compounds 7-10 also could effectively reduce the expression of COX-2 protein.
    Keywords: Anthozoa -- Chemistry ; Anti-Inflammatory Agents -- Isolation & Purification ; Antineoplastic Agents -- Isolation & Purification ; Cyclooxygenase 2 Inhibitors -- Isolation & Purification ; Nitric Oxide Synthase Type II -- Drug Effects ; Withanolides -- Isolation & Purification
    ISSN: 01633864
    E-ISSN: 1520-6025
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  • 2
    Language: English
    In: Journal of natural products, 24 September 2010, Vol.73(9), pp.1482-8
    Description: Eight new phenylpropanoid derivatives [quiquesetinerviusides A (1), B (2), C (3), D (4), and E (5), as well as quiquesetinerviusins A (6), B (7), and C (8)] and seven known compounds (8-15), were isolated from an EtOAc extract of Calamus quiquesetinervius stems. The structures of 1-8 were elucidated on the basis of 1D- and 2D-NMR spectroscopic data analysis. Bioassay results showed that 1-5 possess weak DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activity, but potent (·)OH radical scavenging activity (IC(50) 3.6-8.4 μM). Of the tested isolates, compounds 4-6 and 9 showed potent inhibition (IC(50) 9.2-29.5 μM) of LPS-stimulated NO production when compared with a positive control substance, quercetin (IC(50) 34.5 μM).
    Keywords: Anti-Inflammatory Agents, Non-Steroidal -- Isolation & Purification ; Antioxidants -- Isolation & Purification ; Calamus -- Chemistry ; Drugs, Chinese Herbal -- Isolation & Purification ; Free Radical Scavengers -- Isolation & Purification ; Glycosides -- Isolation & Purification ; Phenylpropionates -- Isolation & Purification
    ISSN: 01633864
    E-ISSN: 1520-6025
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  • 3
    Language: English
    In: Journal of natural products, 24 September 2010, Vol.73(9), pp.1538-43
    Description: Six norterpenes including negombatoperoxides A and B (4 and 5), the inseparable epimers negombatoperoxides C and D (6 and 7), negombatodiol (8), and negombatolactone (9), in combination with three known compounds, (+)-nuapapuin B (1), (+)-nuapapuin B methyl ester (2), and (+)-aikupikoxide C (3), were isolated from the Formosan marine sponge Negombata corticata. In addition, 6,6-dimethylundecane-2,5,10-trione (10) was isolated for the first time from a natural source. Their structures, including relative configurations, were elucidated on the basis of interpretation of spectroscopic data and by the application of the empirical rule established by Capon and MacLeod. The absolute configurations of 8 and 9 were established by the application of Mosher's method and comparison of CD data with known lactones, respectively. Cytotoxicity of these isolates against human breast carcinoma, human liver carcinoma, and human lung carcinoma cell lines was evaluated.
    Keywords: Antineoplastic Agents -- Isolation & Purification ; Peroxides -- Isolation & Purification ; Porifera -- Chemistry ; Terpenes -- Isolation & Purification
    ISSN: 01633864
    E-ISSN: 1520-6025
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  • 4
    Language: English
    In: Journal of natural products, 27 May 2011, Vol.74(5), pp.989-96
    Description: Five new benzofurans, pterolinuses A-E (1-5), six new neoflavonoids, pterolinuses F-J (8-13), and five known compounds (6, 7, 14-16) were isolated from an extract of Pterocarpus santalinus heartwood. All new structures were elucidated by spectroscopic methods, and configurations were confirmed by CD spectral data and optical rotation values. The isolates were evaluated for anti-inflammatory and cytotoxic activities. Six compounds (1, 2, 4, 6, 7, and 15) showed significant inhibition in at least one anti-inflammatory assay. Compound 2 showed the best selective effect against superoxide anion generation in human neutrophils with, an IC50 value of 0.19 μg/mL, and was 6.2-fold more potent than the positive control LY294002. Compound 14 showed the highest cytotoxicity against Ca9-22 cancer cells, with an IC50 value of 0.46 μg/mL.
    Keywords: Anti-Inflammatory Agents -- Isolation & Purification ; Benzofurans -- Isolation & Purification ; Flavonoids -- Isolation & Purification ; Plants, Medicinal -- Chemistry ; Pterocarpus -- Chemistry
    ISSN: 01633864
    E-ISSN: 1520-6025
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  • 5
    Language: English
    In: Journal of natural products, 26 August 2011, Vol.74(8), pp.1698-706
    Description: Arabidopsis thaliana pER8:GUS, a low-cost, highly efficient, and convenient transgenic plant system, was used to assay the estrogen-like activity of 30 traditional Chinese medicines. The MeOH extract of Caesalpinia sappan exhibited significant bioactivity in this assay, and subsequent bioactivity-guided fractionation of the extract led to the isolation of one new compound, (S)-3,7-dihydroxychroman-4-one (1), and 10 known compounds. Both the plant pER8:GUS and in vitro estrogen response element reporter assays were used to evaluate the estrogenic activity of the isolated compounds, and these two systems produced comparable results. Compounds 6, 8, and 11 showed significant estrogenic activity comparable to genistein. These active compounds were determined to be nontoxic new sources of phytoestrogens. In addition, compounds 2 and 3 inhibited ERE transcription induced by 17β-estradiol. A docking model revealed that compounds 6, 8, and 11 showed high affinity to the estrogen receptor. The pER8:GUS reporter system was demonstrated to be a useful and effective technique in phytoestrogen discovery.
    Keywords: Caesalpinia -- Metabolism ; Chromones -- Analysis ; Drugs, Chinese Herbal -- Pharmacology ; Estrogens -- Analysis ; Phytoestrogens -- Analysis
    ISSN: 01633864
    E-ISSN: 1520-6025
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  • 6
    Language: English
    In: Journal of natural products (Print), 2016, Vol.79(11), pp.2805-2813
    Description: Six new and 16 known lanostanoids were isolated from the sclerotia of Poria cocos. The structures of the new isolates were elucidated to be 16α-hydroxy-3-oxo-24-methyllanosta-5,7,9(11),24(31)-tetraen-21-oic acid (1), 3β,16α,29-trihydroxy-24-methyllanosta-7,9(11),24(31)-trien-21-oic acid (2), 3β,16α,30-trihydroxy-24-methyllanosta-7,9(11),24(31)-trien-21-oic...
    Keywords: Natural Sciences ; Biological Sciences ; Biochemistry And Molecular Biology ; Naturvetenskap ; Biologiska Vetenskaper ; Biokemi Och Molekylärbiologi ; Medical And Health Sciences ; Basic Medicine ; Medicinal Chemistry ; Medicin Och Hälsovetenskap ; Medicinska Och Farmaceutiska Grundvetenskaper ; Läkemedelskemi ; Medical And Health Sciences ; Basic Medicine ; Pharmaceutical Sciences ; Medicin Och Hälsovetenskap
    ISSN: 0163-3864
    E-ISSN: 15206025
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  • 7
    Language: English
    In: Journal of natural products, 26 November 2014, Vol.77(11), pp.2367-74
    Description: Fractionation of an ethanol-soluble extract of the seeds of Swietenia macrophylla yielded six new limonoids, swielimonoids A-F (1-6), along with 20 known compounds. Compounds 1 and 2, mexicanolide-type limonoids, were assigned with an α,β-unsaturated δ-lactone moiety (ring D) and a C═C bond between C-8 and C-30. Compounds 3-6 could be categorized as highly oxygenated phragmalin-type limonoids. The structures of these new compounds were elucidated through the interpretation of spectroscopic data. The antidengue virus 2 activities of the isolated components from S. macrophylla were investigated, and of 12 compounds subjected to bioassay, compounds 2 and 7-10 were found to show inhibitory activity in the range 3.5 to 12.5 μM. Among these, the new limonoid 2 exhibited significant antiviral activity (EC50 = 7.2 ± 1.33 μM) with a selectivity index (CC50/EC50) value of 〉27.7.
    Keywords: Antiviral Agents -- Isolation & Purification ; Dengue Virus -- Drug Effects ; Limonins -- Isolation & Purification ; Meliaceae -- Chemistry
    ISSN: 01633864
    E-ISSN: 1520-6025
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  • 8
    Language: English
    In: Journal of natural products (Print), 2016, Vol.79(10), pp.2674-2680
    Description: Zoanthus kuroshio is a colorful zoanthid with a fluorescent pink oral disc and brown tentacles, which dominates certain parts of the Taiwanese and Japanese coasts. This sea anemone is a rich source of biologically active alkaloids. In the current investigation, two novel halogenated zoanthamines [5 alpha-iodozoanthenamine...
    Keywords: Medical And Health Sciences ; Basic Medicine ; Medicinal Chemistry ; Medicin Och Hälsovetenskap ; Medicinska Och Farmaceutiska Grundvetenskaper ; Läkemedelskemi
    ISSN: 0163-3864
    E-ISSN: 15206025
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  • 9
    Language: English
    In: Journal of Natural Products, 07/27/2012, Vol.75(7), pp.1424-1424
    ISSN: 0163-3864
    E-ISSN: 1520-6025
    Source: American Chemical Society (via CrossRef)
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  • 10
    Language: English
    In: Journal of natural products, 26 July 2013, Vol.76(7), pp.1260-6
    Description: The addition of the histone deacetylase inhibitor suberoylanilide hydroxamic acid to a culture of the filamentous fungus Beauveria felina significantly changed its secondary metabolite profile and led to the isolation of eight compounds, including three new cyclodepsipeptides, desmethylisaridin E (1), desmethylisaridin C2 (2), and isaridin F (3), along with five known cyclodepsipeptide compounds. Isaridin F (3) possesses a cyclodepsipeptide ring with N-methylbutyric acid, which is rare in natural peptides. Absolute configurations of the new cyclodepsipeptides were achieved by Marfey's method. The anti-inflammatory activity of the isolated compounds was investigated through evaluating their effect on superoxide anion production and elastase release by FMLP-induced human neutrophils. Among the tested compounds, desmethylisaridin E (1) inhibited superoxide anion production and desmethylisaridin C2 (2) inhibited elastase release, with IC50 values of 10.00 ± 0.80 and 10.01 ± 0.46 μM, respectively.
    Keywords: Beauveria -- Chemistry ; Depsipeptides -- Isolation & Purification ; Histone Deacetylase Inhibitors -- Pharmacology ; Hydroxamic Acids -- Pharmacology
    ISSN: 01633864
    E-ISSN: 1520-6025
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