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  • 1
    Language: English
    In: Nature, 21 January 2016, Vol.529(7586), pp.394-8
    Description: The nature of inter-group relations among prehistoric hunter-gatherers remains disputed, with arguments in favour and against the existence of warfare before the development of sedentary societies. Here we report on a case of inter-group violence towards a group of hunter-gatherers from Nataruk, west of Lake Turkana, which during the late Pleistocene/early Holocene period extended about 30 km beyond its present-day shore. Ten of the twelve articulated skeletons found at Nataruk show evidence of having died violently at the edge of a lagoon, into which some of the bodies fell. The remains from Nataruk are unique, preserved by the particular conditions of the lagoon with no evidence of deliberate burial. They offer a rare glimpse into the life and death of past foraging people, and evidence that warfare was part of the repertoire of inter-group relations among prehistoric hunter-gatherers.
    Keywords: Archaeology ; Group Processes ; Violence -- History ; Wounds and Injuries -- History
    ISSN: 00280836
    E-ISSN: 1476-4687
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  • 2
    Language: English
    In: Nature, February 2019, Vol.566(7744), pp.388-392
    Description: Microglia have critical roles not only in neural development and homeostasis, but also in neurodegenerative and neuroinflammatory diseases of the central nervous system. These highly diverse and specialized functions may be executed by subsets of microglia that already exist in situ, or by specific subsets of microglia that develop from a homogeneous pool of cells on demand. However, little is known about the presence of spatially and temporally restricted subclasses of microglia in the central nervous system during development or disease. Here we combine massively parallel single-cell analysis, single-molecule fluorescence in situ hybridization, advanced immunohistochemistry and computational modelling to comprehensively characterize subclasses of microglia in multiple regions of the central nervous system during development and disease. Single-cell analysis of tissues of the central nervous system during homeostasis in mice revealed specific time- and region-dependent subtypes of microglia. Demyelinating and neurodegenerative diseases evoked context-dependent subtypes of microglia with distinct molecular hallmarks and diverse cellular kinetics. Corresponding clusters of microglia were also identified in healthy human brains, and the brains of patients with multiple sclerosis. Our data provide insights into the endogenous immune system of the central nervous system during development, homeostasis and disease, and may also provide new targets for the treatment of neurodegenerative and neuroinflammatory pathologies.
    Keywords: Single-Cell Analysis ; Spatio-Temporal Analysis ; Microglia -- Classification
    ISSN: 00280836
    E-ISSN: 1476-4687
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  • 3
    In: Nature, 1977, Vol.266(5603), p.639
    Keywords: Chlorpromazine–Pharmacology ; Dopamine–Metabolism ; Dose-Response Relationship, Drug–Pharmacology ; Fluphenazine–Pharmacology ; Haloperidol–Pharmacology ; Humans–Pharmacology ; Male–Metabolism ; Perphenazine–Drug Therapy ; Prochlorperazine–Drug Effects ; Prolactin–Pharmacology ; Schizophrenia–Pharmacology ; Synaptic Transmission–Pharmacology ; Thiothixene–Pharmacology ; Tranquilizing Agents–Pharmacology ; Trifluoperazine–Pharmacology ; Tranquilizing Agents ; Trifluoperazine ; Thiothixene ; Prolactin ; Perphenazine ; Haloperidol ; Fluphenazine ; Chlorpromazine ; Dopamine ; Prochlorperazine;
    ISSN: 0028-0836
    E-ISSN: 1476-4687
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