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  • Nature Communications
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  • 1
    Language: English
    In: Nature Communications, 14 June 2016, Vol.7, p.11847
    Description: Calcium (Ca 2+ ) and redox signalling play important roles in acclimation processes from archaea to eukaryotic organisms. Herein we characterized a unique protein from Chlamydomonas reinhardtii that has the competence to integrate Ca 2+ - and redox-related signalling. This protein, designated as calredoxin (CRX), combines four Ca 2+ -binding EF-hands and a thioredoxin (TRX) domain. A crystal structure of CRX, at 1.6 Å resolution, revealed an unusual calmodulin-fold of the Ca 2+ -binding EF-hands, which is functionally linked via an inter-domain communication path with the enzymatically active TRX domain. CRX is chloroplast-localized and interacted with a chloroplast 2-Cys peroxiredoxin (PRX1). Ca 2+ -binding to CRX is critical for its TRX activity and for efficient binding and reduction of PRX1. Thereby, CRX represents a new class of Ca 2+ -dependent ‘sensor-responder' proteins. Genetically engineered Chlamydomonas strains with strongly diminished amounts of CRX revealed altered photosynthetic electron transfer and were affected in oxidative stress response underpinning a function of CRX in stress acclimation. Calcium and redox signalling have important roles in acclimation processes. Here, the authors characterise a protein from Chlamydomonas reinhardtii that can integrate calcium and redox-related signalling.
    Keywords: Life Sciences ; Life Sciences ; Biochemistry, Molecular Biology ; Algae ; Chlamydomonas Reinhardtii ; Calcium ; Redox Signaling ; Protein ; Calredoxin ; Crx ; Subcellular Localization ; Chloroplast ; Crystal Structure ; Thioredoxin Domain ; Photosynthesis ; Electron Transfer ; Oxidative Stress ; Stress Acclimation ; Biology
    ISSN: 2041-1723
    E-ISSN: 2041-1723
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  • 2
    In: Nature Communications, 2015, Vol.6
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.gloplacha.2009.10.006 Byline: Thomas Felis (a), Norel Rimbu (b)(c) Keywords: Mediterranean; Middle East; Red Sea; palaeoclimate; North Atlantic Oscillation; corals; oxygen isotopes Abstract: Annually banded reef corals from the northern Red Sea provide a high-resolution archive of past climate variations at the southeastern rim of the Mediterranean basin. Subseasonally resolved oxygen isotope records derived from the carbonate skeletons of these massive colonies robustly document seasonality and interannual to decadal climate variability. These proxy records of climate, supported by analyses of instrumental data and model simulations, reveal the prominent role of the Arctic Oscillation/North Atlantic Oscillation (AO/NAO) in controlling eastern Mediterranean/Middle East climate on seasonal, interannual to decadal and orbital timescales, most pronounced during winter. Variability at interannual periods of 5-6yr evident in the coral records is indicative of AO/NAO-like atmospheric variability over the Northern Hemisphere and its influence on eastern Mediterranean/Middle East climate during the last centuries, the late Holocene and the last interglacial period. The coral oxygen isotope records, which are recording temperature and surface evaporation in the northern Red Sea, are linked via AO/NAO-controlled atmospheric circulation changes to variations in temperature and precipitation throughout the Mediterranean and Middle East region. Whereas the entire eastern Mediterranean/Middle East region experiences colder winters during the high-index state of the AO/NAO, the resulting changes in hydrologic balance have a more complex spatial pattern. More arid conditions in the northern Red Sea are accompanied by drier winters in the northeastern Mediterranean but by wetter winters along the southeastern rim of the Mediterranean Sea. This observation may raise difficulties for proxy-based reconstructions of eastern Mediterranean precipitation from the Levant, which is located in the transition zone between positive and negative precipitation anomalies. Compared to the AO/NAO, the atmospheric teleconnections of the El NiA[+ or -]o-Southern Oscillation (ENSO) on eastern Mediterranean/Middle East climate, which are modulated by higher-latitude atmospheric circulation over the North Pacific-North Atlantic region, are weaker and non-stationary. Author Affiliation: (a) MARUM -- Center for Marine Environmental Sciences, University of Bremen, GEO Building, Klagenfurter Str., 28359 Bremen, Germany (b) Department of Atmospheric Physics, Faculty of Physics, University of Bucharest, Bucharest, Romania (c) Climed Norad, Zeicani 25, Bucharest, Romania Article History: Received 19 January 2009; Accepted 19 October 2009
    Keywords: Rain – Analysis ; Precipitation Variability – Analysis ; Atmospheric Physics – Analysis ; Climate – Analysis ; Atmospheric Circulation – Analysis ; Interglacial Periods – Analysis ; El Nino – Analysis ; Carbonates – Analysis ; Natural Cycles – Analysis;
    ISSN: 2041-1723
    ISSN: 09218181
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  • 3
    In: Nature Communications, 2017, Vol.8
    Description: Due to their short wavelength, X-rays can in principle be focused down to a few nanometres and below. At the same time, it is this short wavelength that puts stringent requirements on X-ray optics and their metrology. Both are limited by today's technology. In this work, we present accurate at wavelength measurements of residual aberrations of a refractive X-ray lens using ptychography to manufacture a corrective phase plate. Together with the fitted phase plate the optics shows diffraction-limited performance, generating a nearly Gaussian beam profile with a Strehl ratio above 0.8. This scheme can be applied to any other focusing optics, thus solving the X-ray optical problem at synchrotron radiation sources and X-ray free-electron lasers. X-ray optics are notoriously challenging to fabricate due to the strict tolerances that result from the short wavelength of radiation. Here, Seiboth et al . carefully quantify aberrations in complex X-ray lenses and correct them with an easy-to-fabricate broadband phase plate.
    Keywords: Article;
    ISSN: 2041-1723
    E-ISSN: 2041-1723
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  • 4
    In: Nature Communications, 2014, Vol.5
    Description: The capacity of dendritic cells (DCs) to regulate tumour-specific adaptive immune responses depends on their proper differentiation and homing status. Whereas DC-associated tumour-promoting functions are linked to T-cell tolerance and formation of an inflammatory milieu, DC-mediated direct effects on tumour growth have remained unexplored. Here we show that deletion of DCs substantially delays progression of Myc-driven lymphomas. Lymphoma-exposed DCs upregulate immunomodulatory cytokines, growth factors and the CCAAT/enhancer-binding protein β (C/EBPβ). Moreover, Eμ-Myc lymphomas induce the preferential translation of the LAP/LAP* isoforms of C/EBPβ. C/EBPβ(-/-) DCs are unresponsive to lymphoma-associated cytokine changes and in contrast to wild-type DCs, they are unable to mediate enhanced Eμ-Myc lymphoma cell survival. Antigen-specific T-cell proliferation in lymphoma-bearing mice is impaired; however, this immune suppression is reverted by the DC-restricted deletion of C/EBPβ. Thus, we show that C/EBPβ-controlled DC functions are critical steps for the creation of a lymphoma growth-promoting and -immunosuppressive niche.
    Keywords: Ccaat-Enhancer-Binding Protein-Beta -- Immunology ; Dendritic Cells -- Immunology ; Lymphoma, B-Cell -- Immunology ; Oncogene Protein P55(V-Myc) -- Immunology;
    ISSN: 2041-1723
    E-ISSN: 2041-1723
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  • 5
    Language: English
    In: Nature Communications, 01 September 2018, Vol.9(1), pp.1-15
    Description: Injuries in the embryonal kidney can be repaired by a cell migratory response but how this is regulated at a molecular level is unclear. Here, the authors show in mice that deletion of Cxcl12 and Myc delays pronephros injury repair by changing mitochondrial metabolism and glycolysis.
    Keywords: Biology
    E-ISSN: 2041-1723
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  • 6
    Language: English
    In: Nature Communications, 01 August 2018, Vol.9(1), pp.1-9
    Description: The European X-ray free-electron laser (EuXFEL) in Hamburg is the first megahertz (MHz) repetition rate XFEL. Here the authors use lysozyme crystals and microcrystals from jack bean proteins and demonstrate that damage-free high quality data can be collected at a MHz repetition rate.
    Keywords: Biology
    E-ISSN: 2041-1723
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  • 7
    Language: English
    In: Nature Communications, 01 June 2019, Vol.10(1), pp.1-9
    Description: The performance of organic semiconductor devices depends heavily on molecular parameters. Here, Schwarze et al. point out that the molecular quadrupole moment largely influences device energy levels and show how quadrupole moments can reduce the energy barrier for charge generation in solar cells.
    Keywords: Biology
    ISSN: Nature Communications
    E-ISSN: 2041-1723
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  • 8
    Language: English
    In: Nature Communications, 2018, Vol. 9
    Description: Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.
    Keywords: Medical And Health Sciences ; Basic Medicine ; Medical Genetics ; Medicin Och Hälsovetenskap ; Medicinska Och Farmaceutiska Grundvetenskaper ; Medicinsk Genetik ; Medical And Health Sciences ; Clinical Medicine ; Cardiac And Cardiovascular Systems ; Medicin Och Hälsovetenskap ; Klinisk Medicin ; Kardiologi
    ISSN: 2041-1723
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  • 9
    In: Davies, Gail; Lam, Max; Harris, Sarah E. Trampush, Joey W.; Luciano, Michelle; Hill, W. David; Hagenaars, Saskia P.; Ritchie, Stuart J.; Marioni, Riccardo E.; Fawns-Ritchie, Chloe; Liewald, David C. M.; Okely, Judith A.; Ahola-Olli, Ari V.; Barnes, Catriona L. K.; Bertram, Lars; Bis, Joshua C.; Burdick, Katherine E.; Christoforou, Andrea; DeRosse, Pamela; Djurovic, Srdjan; Espeseth, Thomas; Giakoumaki, Stella; Giddaluru, Sudheer; Gustavson, Daniel E.; Hayward, Caroline; Hofer, Edith; Ikram, M. Arfan; Karlsson, Robert; Knowles, Emma; Lahti, Jari; Leber, Markus; Li, Shuo; Mather, Karen A.; Melle, Ingrid; Morris, Derek; Oldmeadow, Christopher; Palviainen, Teemu; Payton, Antony; Pazoki, Raha; Petrovic, Katja; Reynolds, Chandra A.; Sargurupremraj, Muralidharan; Scholz, Markus; Smith, Jennifer A.; Smith, Albert V.; Terzikhan, Natalie; Thalamuthu, Anbupalam; Trompet, Stella; van der Lee, Sven J.; Ware, Erin B.; Windham, B. Gwen; Wright, Margaret J.; Yang, Jingyun; Yu, Jin; Ames, David; Amin, Najaf; Amouyel, Philippe; Andreassen, Ole A.; Armstrong, Nicola J.; Assareh, Amelia A.; Attia, John R.; Attix, Deborah; Avramopoulos, Dimitrios; Bennett, David A.; Böhmer, Anne C.; Boyle, Patricia A.; Brodaty, Henry; Campbell, Harry; Cannon, Tyrone D.; Cirulli, Elizabeth T.; Congdon, Eliza; Conley, Emily Drabant; Corley, Janie; Cox, Simon R.; Dale, Anders M.; Dehghan, Abbas; Dick, Danielle; Dickinson, Dwight; Eriksson, Johan G.; Evangelou, Evangelos; Faul, Jessica D.; Ford, Ian; Freimer, Nelson A.; Gao, He; Giegling, Ina; Gillespie, Nathan A.; Gordon, Scott D.; Gottesman, Rebecca F.; Griswold, Michael E.; Gudnason, Vilmundur; Harris, Tamara B.; Hartmann, Annette M.; Hatzimanolis, Alex; Heiss, Gerardo; Holliday, Elizabeth G.; Joshi, Peter K.; Kähönen, Mika; Kardia, Sharon L. R.; Karlsson, Ida; Kleineidam, Luca; Knopman, David S.; Kochan, Nicole A.; Konte, Bettina; Kwok, John B.; Le Hellard, Stephanie; Lee, Teresa; Lehtimäki, Terho; Li, Shu-Chen; Liu, Tian; Koini, Marisa; London, Edythe; Longstreth, Will T.; Lopez, Oscar L.; Loukola, Anu; Luck, Tobias; Lundervold, Astri J.; Lundquist, Anders; Lyytikäinen, Leo-Pekka; Martin, Nicholas G.; Montgomery, Grant W.; Murray, Alison D.; Need, Anna C.; Noordam, Raymond; Nyberg, Lars; Ollier, William; Papenberg, Goran; Pattie, Alison; Polasek, Ozren; Poldrack, Russell A.; Psaty, Bruce M.; Reppermund, Simone; Riedel-Heller, Steffi G.; Rose, Richard J.; Rotter, Jerome I.; Roussos, Panos; Rovio, Suvi P.; Saba, Yasaman; Sabb, Fred W.; Sachdev, Perminder S.; Satizabal, Claudia L.; Schmid, Matthias; Scott, Rodney J.; Scult, Matthew A.; Simino, Jeannette; Slagboom, P. Eline; Smyrnis, Nikolaos; Soumaré, Aïcha; Stefanis, Nikos C.; Stott, David J.; Straub, Richard E.; Sundet, Kjetil; Taylor, Adele M.; Taylor, Kent D.; Tzoulaki, Ioanna; Tzourio, Christophe; Uitterlinden, André; Vitart, Veronique; Voineskos, Aristotle N.; Kaprio, Jaakko; Wagner, Michael; Wagner, Holger; Weinhold, Leonie; Wen, K. Hoyan; Widen, Elisabeth; Yang, Qiong; Zhao, Wei; Adams, Hieab H. H.; Arking, Dan E.; Bilder, Robert M.; Bitsios, Panos; Boerwinkle, Eric; Chiba-Falek, Ornit; Corvin, Aiden; De Jager, Philip L.; Debette, Stéphanie; Donohoe, Gary; Elliott, Paul; Fitzpatrick, Annette L.; Gill, Michael; Glahn, David C.; Hägg, Sara; Hansell, Narelle K.; Hariri, Ahmad R.; Ikram, M. Kamran; Jukema, J. Wouter; Vuoksimaa, Eero; Keller, Matthew C.; Kremen, William S.; Launer, Lenore; Lindenberger, Ulman; Palotie, Aarno; Pedersen, Nancy L.; Pendleton, Neil; Porteous, David J.; Räikkönen, Katri; Raitakari, Olli T.; Ramirez, Alfredo; Reinvang, Ivar; Rudan, Igor; Dan Rujescu, ; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter W.; Schofield, Peter R.; Starr, John M.; Steen, Vidar M.; Trollor, Julian N.; Turner, Steven T.; Van Duijn, Cornelia M.; Villringer, Arno; Weinberger, Daniel R.; Weir, David R.; Wilson, James F.; Malhotra, Anil; McIntosh, Andrew M.; Gale, Catharine R.; Seshadri, Sudha; Mosley, Thomas H.; Bressler, Jan; Lencz, Todd; Deary, Ian J. (2018). Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications 9 ,
    Description: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P 〈 5 x 10(-8)) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
    Keywords: Genome-Wide Association ; Human Intelligence ; Reaction-Time ; Educational-Attainment ; Parkinsons-Disease ; Processing Speed ; Common Variants ; Human Longevity ; Old-Age ; Metaanalysis
    ISBN: 0004332979000
    ISSN: 2041-1723
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  • 10
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