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Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma (2019)

Catherine Lee ; Vasilisa A. Rudneva ; Serap Erkek ; [et al.]

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Language: English

In: Nature Communications, 01 January 2019, Vol.10(1), pp.1-13

Description: Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal...

Keywords: Biology

E-ISSN: 2041-1723

DOI: 10.1038/s41467-018-08269-5

URL: View full text in DOAJ

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