Phytochemistry, 2010, Vol.71, pp.271-279
Tricin-type flavonolignans, (2S)-dihydrotricin 4'-O-(erythro-β-guaiacylglyceryl) ether, (2S)-dihydrotricin 4'-O-(threo-β-guaiacylglyceryl) ether, (2S)-dihydrotricin 4'-O-(threo-β-4-hydroxyphenylglyceryl) ether, tricin 4'-O-(erythro-β-4-hydroxyphenylglyceryl) ether, tricin 4'-O-(threo-β-4-hydroxylphenylglyceryl) ether, and (2S)-dihydrotricin 4'-O-(β-6"-methoxy-4"-oxo-chroman-3"-yloxy) ether namely calquiquelignan A-F, respectively, were isolated and characterized from the EtOAc extract of Calamus quiquesetinervius. Additionally, six known phenolic compounds, including dihydrotricin, tricin, salcolin A, p-hydroxybenzoic acid, (2S, 3S)-trans-dihydrokapempferol and (2S)-naringenin, were also obtained and identified from the extract. Structures of the flavonolignans were assigned based on spectroscopic analyses that included 1D and 2D NMR spectroscopic techniques, such as HMQC, HMBC, and NOESY. Bioassay results showed that calquiquelignan A, dihydrotricin and (2S)-naringenin exhibited significant vasodilatory potencies, as indicated by 60.3%, 80.3% and 60.9% relaxations, respectively, at 100 μM. Salcolin A showed potent platelet aggregation inhibition, compared with aspirin. Most of the tricin-type derivatives (calquiquelignan A-B, dihydrotricin and tricin) also exhibited more potent hydroxyl radical (free radicals OH) scavenging activity than trolox as characterized by the ultraweak chemiluminescence assay. ; Includes references ; p. 271-279.
Human Health ; Rabbits ; Medicinal Plants ; Spectral Analysis ; Animal Disease Models ; Vasodilation ; Oxidative Stress ; Flavonoids ; Medicinal Properties ; Antioxidant Activity ; Platelet Aggregation ; Lignans ; Chemical Structure ; Stereochemistry ; Calamus ; Rats ; Tricin ; Calamus Quiquesetinervius ; Calquiquelignan ; Flavonolignans
AGRIS (Food and Agriculture Organization of the United Nations)
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