Kooperativer Bibliotheksverbund

Berlin Brandenburg

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  • Science  (166)
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  • 1
    Language: English
    In: Science (New York, N.Y.), 11 June 2010, Vol.328(5984), pp.1394-8
    Description: Gamma-interferon-inducible lysosomal thiolreductase (GILT) promotes major histocompatibility complex (MHC) class II-restricted presentation of exogenous antigens containing disulfide bonds. Here, we show that GILT also facilitates MHC class I-restricted recognition of such antigens by CD8+ T cells, or cross-presentation. GILT is essential for cross-presentation of a CD8+ T cell epitope of glycoprotein B (gB) from herpes simplex virus 1 (HSV-1) but not for its presentation by infected cells. Initiation of the gB-specific CD8+ T cell response during HSV-1 infection, or cross-priming, is highly GILT-dependent, as is initiation of the response to the envelope glycoproteins of influenza A virus. Efficient cross-presentation of disulfide-rich antigens requires a complex pathway involving GILT-mediated reduction, unfolding, and partial proteolysis, followed by translocation into the cytosol for proteasomal processing.
    Keywords: Cross-Priming ; Antigens, Viral -- Immunology ; Herpes Simplex -- Immunology ; Herpesvirus 1, Human -- Immunology ; Oxidoreductases -- Metabolism ; Viral Envelope Proteins -- Immunology
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 2
    Language: English
    In: Science (New York, N.Y.), 13 October 2017, Vol.358(6360), pp.161
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 3
    Language: English
    In: Science (New York, N.Y.), 01 December 2017, Vol.358(6367), pp.1118
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 4
    In: Science, 08/19/2016
    ISSN: 0036-8075
    E-ISSN: 1095-9203
    Source: American Association for the Advancement of Science (via CrossRef)
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  • 5
    Article
    Article
    Language: English
    In: Science (New York, N.Y.), 19 August 2016, Vol.353(6301), pp.838
    Description: “Isn't this just a glorified postdoc position? Won't taking this offer hurt my chances of landing a tenure-track professor position?” These were the questions I asked my adviser when he offered me a promotion from postdoc to assistant research scientist, the title given to non–tenure-track
    Keywords: Career Choice ; Career Mobility
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 6
    Language: English
    In: Science (New York, N.Y.), 02 September 2011, Vol.333(6047), pp.1254-6
    Description: In our view, synthetic biology is an extension of the continuum of genetic science that has been used safely for more than 40 years by the biotechnology industry in the development of commercial products. Examples of synthetic biology use by biotechnology companies illustrate the potential to substantially reduce research and development time and to increase speed to market. Improvements in the speed and cost of DNA synthesis are enabling scientists to design modified bacterial chromosomes that can be used in the production of renewable chemicals, biofuels, bioproducts, renewable specialty chemicals, pharmaceutical intermediates, fine chemicals, food ingredients, and health care products. Regulatory options should support innovation and commercial development of new products while protecting the public from potential harms.
    Keywords: Biotechnology ; Government Regulation ; Synthetic Biology
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 7
    Language: English
    In: Science (New York, N.Y.), 25 January 2013, Vol.339(6118), pp.446-8
    Description: The human genome contains ~50 genes that were derived from transposable elements or transposons, and many are now integral components of cellular gene expression programs. The human THAP9 gene is related to the Drosophila P-element transposase. Here, we show that human THAP9 can mobilize Drosophila P-elements in both Drosophila and human cells. Chimeric proteins formed between the Drosophila P-element transposase N-terminal THAP DNA binding domain and the C-terminal regions of human THAP9 can also mobilize Drosophila P elements. Our results indicate that human THAP9 is an active DNA transposase that, although "domesticated," still retains the catalytic activity to mobilize P transposable elements across species.
    Keywords: DNA Transposable Elements ; Transposases -- Genetics
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 8
    Language: English
    In: Science (New York, N.Y.), 14 August 2015, Vol.349(6249), pp.747-50
    Description: The evolution of sexual reproduction is often explained by Red Queen dynamics: Organisms must continually evolve to maintain fitness relative to interacting organisms, such as parasites. Recombination accompanies sexual reproduction and helps diversify an organism's offspring, so that parasites cannot exploit static host genotypes. Here we show that Drosophila melanogaster plastically increases the production of recombinant offspring after infection. The response is consistent across genetic backgrounds, developmental stages, and parasite types but is not induced after sterile wounding. Furthermore, the response appears to be driven by transmission distortion rather than increased recombination. Our study extends the Red Queen model to include the increased production of recombinant offspring and uncovers a remarkable ability of hosts to actively distort their recombination fraction in rapid response to environmental cues.
    Keywords: Biological Evolution ; Genetic Fitness ; Recombination, Genetic ; Drosophila Melanogaster -- Genetics
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 9
    Language: English
    In: Science (New York, N.Y.), 06 May 2011, Vol.332(6030), pp.729-32
    Description: The unfolded protein response (UPR), which is activated when unfolded or misfolded proteins accumulate in the endoplasmic reticulum, has been implicated in the normal physiology of immune defense and in several human diseases, including diabetes, cancer, neurodegenerative disease, and inflammatory disease. In this study, we found that the nervous system controlled the activity of a noncanonical UPR pathway required for innate immunity in Caenorhabditis elegans. OCTR-1, a putative octopamine G protein-coupled catecholamine receptor (GPCR, G protein-coupled receptor), functioned in sensory neurons designated ASH and ASI to actively suppress innate immune responses by down-regulating the expression of noncanonical UPR genes pqn/abu in nonneuronal tissues. Our findings suggest a molecular mechanism by which the nervous system may sense inflammatory responses and respond by controlling stress-response pathways at the organismal level.
    Keywords: Genes, Helminth ; Immunity, Innate ; Caenorhabditis Elegans -- Genetics ; Caenorhabditis Elegans Proteins -- Physiology ; Pseudomonas Aeruginosa -- Immunology ; Receptors, G-Protein-Coupled -- Physiology ; Sensory Receptor Cells -- Physiology ; Unfolded Protein Response -- Genetics
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 10
    Language: English
    In: Science, 11 June 2010, Vol.328(5984), pp.1394-1398
    Description: Gamma-interferon-inducible lysosomal thiolreductase (GILT) promotes major histocompatibility complex (MHC) class II—restricted presentation of exogenous antigens containing disulfide bonds. Here, we show that GILT also facilitates MHC class I—restricted recognition of such antigens by CDe⁺ T cells, or cross-presentation. GILT is essential for cross-presentation of a CD8⁺ T cell epitope of glycoprotein B (gB) from herpes simplex virus 1 (HSV-1) but not for its presentation by infected cells. Initiation of the gB-specific CD8⁺ T cell response during HSV-1 infection, or cross-priming, is highly GILT-dependent, as is initiation of the response to the envelope glycoproteins of influenza A virus. Efficient crosspresentation of disulfide-rich antigens requires a complex pathway involving GILT-mediated reduction, unfolding, and partial proteolysis, followed by translocation into the cytosol for proteasomal processing.
    ISSN: 00368075
    E-ISSN: 10959203
    Source: Archival Journals (JSTOR)
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