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  • 1
    In: Sexually Transmitted Diseases, 2002, Vol.29(2), pp.114-118
    Description: BACKGROUND : Naturally occurring chancroid is usually more prevalent in men than in women. GOAL : To examine whether there were gender differences in susceptibility to Haemophilus ducreyi infection by analyzing the papule and pustule formation rates for men and women who were experimentally inoculated with Haemophilus ducreyi. STUDY DESIGN : Ninety volunteers were included in the analysis. A total of 189 sites were available for estimation of the papule formation rate, and 166 sites for estimation of the pustule formation rates using logistic regression modeling. RESULTS : Although there were no gender differences in papule formation rates, the women had significantly lower rates of pustule formation than the men after adjustment for the estimated delivered dose. CONCLUSIONS : In women the disease will resolve and not progress to the pustular stage of disease as often as in men. The high male-to-female ratio in naturally occurring chancroid may in part reflect biological differences in gender susceptibility to disease progression, although the mechanisms responsible for this difference are unclear.
    Keywords: Chancroid -- Demographic Aspects ; Disease Sex Factors -- Research ; Disease Susceptibility -- Demographic Aspects;
    ISSN: 0148-5717
    E-ISSN: 15374521
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  • 2
    In: Sexually Transmitted Diseases, 2000, Vol.27(2), pp.111-114
    Description: BACKGROUND AND OBJECTIVES:: To study Haemophilus ducreyi pathogenesis, the authors developed an experimental model of infection in human volunteers. The authors analyze their cumulative experience with strain 35000 in the model and calculate the papule and pustule formation rates for estimated delivered doses (EDDs) ranging from 1 cfu to 100 cfu. STUDY DESIGN:: RESULTS:: CONCLUSION:: H ducreyi is highly infectious for humans. Inoculation of an EDD of 1 cfu causes a papule formation rate of 50%. Pustule formation rates are approximately 50% for 27 cfu and 90% for 100 cfu.
    Keywords: Hemophilus Infections -- Research;
    ISSN: 0148-5717
    E-ISSN: 15374521
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