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  • German  (38)
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  • 1
    Language: German
    In: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, September 2015, Vol.58(9), pp.1025
    Description: N-Ethyl-2-pyrrolidone (NEP), a polar aprotic solvent, is used in many applications as substitute for the structural analogue N-methyl-2-pyrrolidone (NMP), e. g. for surface coatings, in cleaning agents and paint strippers. Monitoring studies indicate that individuals within the general public, without occupational exposure, may be exposed to NEP to an extent, which is comparable to NMP. As NMP, NEP presents a potential health hazard due to its developmental toxicity and teratogenicity. Exposure to NEP can be quantified by the determination of the excretion of its urinary metabolites 5-Hydroxy-N-ethyl-2-pyrrolidone (5-HNEP) and 2-Hydroxy-N-ethylsuccinimide (2-HESI). For the derivation of HBM values, the german Human Biomonitoring Commission (HBM commission) evaluated different toxicological endpoints and finally decided on the BMDL05 and the BMD10 for the endpoint “reduced grasp intensity” of a subchronic feeding study with rats as point of departure (POD) for further procedural steps. The resulting HBM-I and HBM-II values for the sum of the metabolites 5-HNEP and 2-HESI in the urine of children are 10 resp. 25 mg/l and in the urine of adults are 15 resp. 40 mg/l. If the HBM values are exceeded, a check-up will be necessary at first. Measurements above the HBM-II value give cause for concern, especially for pregnant women. Air measurements to determine the source of exposure can be useful. The possibility of skin absorption from use of cleaning agents and paint strippers should also be traced. As NEP und NMP have similar toxic effects, a potential mixed exposure to both substances has to be taken into account.
    Keywords: Guidelines As Topic ; Maximum Allowable Concentration ; Biological Assay -- Standards ; Environmental Exposure -- Analysis ; Environmental Pollutants -- Urine ; Pyrrolidinones -- Urine;
    ISSN: 14369990
    E-ISSN: 1437-1588
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  • 2
    Language: German
    In: pädiatrie: Kinder- und Jugendmedizin hautnah, 4/2016, Vol.28(2), pp.34-35
    ISSN: 1867-2132
    E-ISSN: 2196-6443
    Source: Springer (via CrossRef)
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  • 3
    Language: German
    In: ProCare, 2017, Vol.22(9), pp.16-17
    Description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00735-017-0829-6 Byline: Sabine Wicker (1), Holger F. Rabenau (2) Author Affiliation: (1) BetriebsAaAaAeAnrztlicher Dienst/UniversitAaAaAeAntsklinikum Frankfurt, Theodor-Stern 7, D-60590, Frankfurt am Main, Deutschland (2) 0000 0004 0578 8220, grid.411088.4, Institut fAaAaAeA r Medizinische Virologi UniversitAaAaAeAntsklinikum Frankfurt, Paul-Ehrlich-Stra[sz]e 40, D-60596, Frankfu am Main, Deutschland Article History: Registration Date: 10/11/2017 Online Date: 10/11/2017
    Keywords: Medicine & Public Health ; Nursing ; Nursing;
    ISSN: 0949-7323
    E-ISSN: 1613-7574
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  • 4
    Language: German
    In: MMW - Fortschritte der Medizin, 11/2015, Vol.157(19), pp.49-50
    ISSN: 1438-3276
    E-ISSN: 1613-3560
    Source: Springer (via CrossRef)
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  • 5
    In: LaboratoriumsMedizin, 01/1/2015, Vol.39(6)
    Description: Background: Hundreds of West African healthcare workers (HCW) have become ill with Ebola virus disease (EVD) and died during the recent outbreak. The occurrence of occupational infections in laboratories could be due to the lack of use of personal protective equipment, the failure to implement specific regulations about the use of equipment and how to work with hazardous materials. Our study attempted to assess the information as well as training level of HCW of a German high level isolation unit and their concern over an occupationally acquired EVD. Methods: During the recent Ebola virus outbreak a survey was conducted among HCWs, using an anonymous questionnaire. Results: Although 70% of our total study population stated that they have all the information needed to care for Ebola patients, only 18.2% of laboratory workers and 29.4% of the HCW of the virology department felt sufficiently trained. The HCW rated the Internet (64.3%) and the daily press (54.3%) as the most important sources of information. Medical literature (45.7%) and official institutions (40.4%) were rated less often. Conclusions: Formulated pointedly, the HCW turned to popular science to get the information they need to feel safe. Further in house training regarding practical skills and reference to scientific literature would be a better solution to ensure workplace safety.
    Keywords: Infektion ; Afrika ; Laboratorien ; Informationsquelle ; Internet ; Virologie ; Tageszeitung ; Persönliche Schutzausrüstung ; Gefährlicher Arbeitsstoff ; Fachliteratur ; Arbeitsplatz ; Arbeitssicherheit ; Viruskrankheit ; Isolation ; Medicine;
    ISSN: 0342-3026
    E-ISSN: 1439-0477
    Source: Walter de Gruyter (via CrossRef)
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  • 6
    Language: German
    In: Krankenhaus-Hygiene + Infektionsverhutung, May 2010, Vol.32(2), pp.42-45
    Description: Trotz jahrzehntelanger Bemühungen medizinisches Personal von der Notwendigkeit der Influenzaimpfung zu überzeugen, sind die Impfraten nach wie vor ungenügend. Nachdem der H1N1-Impfstoff Ende Oktober 2009 in Deutschland zur Verfügung stand, begannen Maßnahmen zur Durchimpfung des medizinischen Personals. Höchstwahrscheinlich weniger als 20% der Mitarbeiter des Gesundheitswesens haben sich bis Januar 2010 gegen H1N1/2009 impfen lassen. Ungeimpfte Mitarbeiter des Gesundheitswesens, die sich mit Influenza infizieren, können sowohl ihre Familie, ihre Kollegen, als auch ihre Patienten, die häufig ein erhöhtes Risiko für schwere Infektionsverläufe aufweisen, anstecken. Die aktuell niedrigen Durchimpfungsraten des medizinischen Personals machen deutlich, dass sowohl Maßnahmen zur Erhöhung der saisonalen Impfquote als auch zur H1N1-Impfrate erforderlich sind. Despite decades of effort to encourage health care workers (HCWs) to be immunized against seasonal influenza, vaccination coverage remains insufficient. Efforts to vaccinate German HCWs against “swine flu” (Influenza A H1N1/2009) began when H1N1/2009-vaccine became available at the end of October 2009. In all probability, less than 20% of HCWs had been vaccinated until January 2010. Unvaccinated HCWs who become infected risk transmitting the flu virus to their family, co-workers or patients, who often are at high risk of severe influenza. The current high percentage of unvaccinated HCWs highlights the need to strengthen measures to improve seasonal influenza as well as H1N1-vaccination coverage among HCWs.
    Keywords: Influenza ; Influenzaimpfraten ; Maßnahmen Zum Infektionsschutz ; Mitarbeiter Im Gesundheitswesen ; Neue Influenza ; Influenza ; Influenza Immunization Rates ; Infection Control Measures ; Healthcare Workers ; Novel Influenza ; Public Health
    ISSN: 0720-3373
    E-ISSN: 1876-4495
    Source: ScienceDirect Journals (Elsevier)
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  • 7
    Language: English
    In: Deutsches Arzteblatt international, February 2013, Vol.110(5), pp.61-7
    Description: An estimated 1 million needlestick injuries (NSIs) occur in Europe each year. The Council Directive 2010/32/EU on the prevention of NSIs describes minimum requirements for prevention and calls for the implementation of local, national and Europe-wide reporting systems. The Directive is to be implemented by all EU member states by 11 May 2013. The purpose of this study was to assess (and improve) the procedures for the reporting and treatment of needlestick injuries in a German tertiary-care hospital. We carried out a prospective observational study of the NSI reporting system in the hospital over a period of 18 months and determined the incidence of NSIs, the prevalence of blood-borne pathogens among index patients, the rate of initiation of post-exposure prophylaxis, and the rate of serological testing of the affected health care personnel. 519 instances of NSI were reported to the accident insurance doctor over the period of the study, which consisted of 547 working days. 86.5% of the index patients underwent serological study for hepatitis B and C (HBV and HCV) and for the human immune deficiency virus (HIV); this resulted in two initial diagnoses (one each of active hepatitis B and hepatitis C) in the index patient. 92 of 449 index patients, or one in five, was infected with at least one blood-borne pathogen. HIV post-exposure prophylaxis was initiated in 41 health care workers. One case of hepatitis C virus transmission arose and was successfully treated. Other than that, no infection was transmitted. Complete reporting of NSIs is a prerequisite for the identification of risky procedures and to ensure optimal treatment of the affected health care personnel. The accident insurance doctor must possess a high degree of interdisciplinary competence in order to treat NSI effectively.
    Keywords: Disease Notification -- Statistics & Numerical Data ; Needlestick Injuries -- Epidemiology ; Occupational Injuries -- Epidemiology ; Virus Diseases -- Epidemiology
    E-ISSN: 1866-0452
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  • 8
    Language: German
    In: Deutsches Aerzteblatt Online, 2010
    Keywords: Medicine;
    ISSN: Deutsches Aerzteblatt Online
    E-ISSN: 1866-0452
    Source: CrossRef
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  • 9
    Language: German
    In: Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie, 2008, Vol.58(6), pp.182-183
    Keywords: Medicine & Public Health ; Occupational Medicine/Industrial Medicine;
    ISSN: 0944-2502
    E-ISSN: 2198-0713
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  • 10
    In: LaboratoriumsMedizin, 2009, Vol.33(4), pp.223-227
    Description: Medizinstudenten sind im Rahmen ihrer klinischen Ausbildung einer erhöhten Infektionsgefährdung ausgesetzt. Dessen ungeachtet sind die Impfraten der Medizinstudenten ungenügend. Ein adäquater Impfstatus der Medizinstudenten vor Beginn ihres klinischen Ausbildungsabschnitts ist jedoch wichtig, um nosokomiale Infektionen zu vermeiden.
    Description: Im April und Mai 2007 wurden insgesamt 366 Serumproben von Medizinstudenten des ersten klinischen Semesters ausgewertet. Die serologischen Untersuchungen erfolgten mittels etablierter ELISA-Systeme. Untersucht wurde auf spezifische Antikörper gegen Masern, Mumps, Röteln, Varizellen, Hepatitis B (HBV), Hepatitis C (HCV) und HIV.
    Description: Insgesamt 63,9% (n=234) der Studenten waren gegen Hepatitis B geimpft (Grundimmunisierung, drei Impfdosen). Dagegen hatten 31,7% (n=116) der Studenten bisher noch keine Hepatitis B-Impfung und 4,4% (n=16) kein komplettes Impfschema erhalten (〈drei Impfungen). Zwei Studenten zeigten serologische Marker einer abgelaufenen HBV-Infektion. Es wurde die Erstdiagnose einer HCV-Infektion sowie die Erstdiagnose einer HIV-Infektion gestellt. Bei 7,9% (Masern), 17,5% (Mumps), 6,5% (Röteln) und 2,2% (Varizellen) der Studenten konnten keine virusspezifischen Antikörper nachgewiesen werden.
    Description: Es sollten weitere Anstrengungen unternommen werden, um die Impfraten der Medizinstudenten zu verbessern. Es ist wichtig, Immunitätslücken zu identifizieren und vor dem ersten Patientenkontakt zu schließen. Im Hinblick auf die Erstdiagnose und die Folgen schwerwiegender blutübertragbarer Erkrankungen (z.B. HBV, HCV und HIV) sollten Medizinstudenten auf diese Infektionen untersucht werden.
    Description: Medical students are exposed to infectious diseases during the course of their clinical training. Unfortunately, vaccination rates among medical students remain insufficient. However, immunizations against vaccine-preventable diseases should be carried out before the students enter clinical courses. This is vital in order to prevent nosocomial infections. We screened 366 medical students in their first clinical year for hospital-related viral diseases. Serum samples were collected between April and May 2007. Antibody testing was carried out using commercial ELISA systems against measles, mumps, rubella, varicella, hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV). Overall, 63.9% (n=234) of the students were sufficiently vaccinated against HBV. In contrast, 31.7% (n=116) had not received any HBV vaccine dosage, and 4.4% (n=16) had not completed the full vaccine cycle (〈3 dosage). Remarkably, two students showed serological markers of resolved HBV infection. In addition, one student was HCV-positive and one was HIV-positive, respectively. The following seronegative rates were found: measles (7.9%), mumps (17.5%), rubella (6.5%), and varicella (2.2%). Further work is needed to identify optimal strategies for improving vaccination rates among medical students. It is imperative to identify and limit possible disparities in immunity of vaccine-preventable diseases before initial patient contact. With regard to the primary diagnosis of serious virus diseases including HBV, HCV and HIV, medical students should be screened for these blood borne pathogens.
    Keywords: Blutübertragbare Infektionskrankheiten ; Impfraten ; Medizinstudenten ; Blood Borne Infection ; Medical Students ; Vaccine Uptake Rates
    ISSN: 0342-3026
    E-ISSN: 1439-0477
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