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  • German  (9)
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  • 1
    Keywords: Water Resources Research
    ISSN: 14391783
    Source: DataCite
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  • 2
    Language: German
    In: Onkopipeline, 2009, Vol.2(1), pp.23-29
    Description: Trotz ermutigender Daten in der Primärtherapie von Glioblastompatienten mit Methylierung des Promotors der O 6 -Methylguanyl-Methyltransferase (MGMT) ist neben der weiteren Optimierung dieser Therapie vor allem die Entwicklung von effektiven Rezidivtherapien vordringlich. In Analogie zu präklinischen Ergebnissen wurde vermutet, dass das Verständnis molekularer prognostischer und insbesondere für eine spezifische Therapie prädiktiver Parameter eine verbesserte Patientenselektion vor Therapie- oder Studienbeginn ermögliche und damit den unselektiven Einsatz selektiv wirkender Therapien verhindere. Aktuell verfügbare molekulare Parameter sind allerdings vor allem prognostisch und nicht prädiktiv. Aktuelle multinationale Studienkonzepte bei malignen Gliomen schließen dennoch erstmals Patienten nach vorhergehender molekularer Untersuchung des 1p/19q-Status oder der Methylierung des MGMT-Promotors ein. Eine Herausforderung für neue Studien ist neben der unmittelbaren Verbesserung der Therapie die Etablierung molekularer prädiktiver Signaturen. Aufgrund der drängenden klinischen Situation und der biologischen Spezifika von hirneigenen Tumoren werden aktuell auch neuartige Konzepte wie die Entwicklung zellulärer Vehikel für die Therapie oder die Verwendung von lentiviral tranduziertem, alkylanzienresistentem Knochenmark untersucht. Classic chemo- or radiotherapy alone are not going to make significant impact in the future treatment of malignant glioma. A better understanding of molecular prognostic or preferentially predictive molecular markers enables an improved patient selection prior to radio- or chemotherapy and reduces the risk of unselective administration of targeted therapies. Over the past years, loss of heterozygosity on chromosomes 1p/19q in anaplastic oligodendro - glial tumors as well as analysis of promoter methylation of the O-methylguanine-DNA methyltransferase harbored important prognostic and the latter even predictive information on the sensitivity toward an alkylating chemotherapy. Newly developed multinational studies on malignant glioma for the first time ever include patients according to molecular parameters. Novel molecular signatures as well as targeted therapeutics ask for new studies, preferentially in combination with cytotoxic chemotherapeutics or radiotherapy.
    Keywords: Brain tumors ; Bevacizumab ; Enzastaurin ; Temsirolimus
    ISSN: 1866-5861
    E-ISSN: 1866-587X
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  • 3
    Language: English
    In: Der Nervenarzt, 2019, Vol.90(8), p.809(8)
    Description: Byline: Afshin Saffari (1), Markus Weiler (2), Georg Friedrich Hoffmann (1), Andreas Ziegler (1) Keywords: Duchenne-Muskeldystrophie; Gentherapie; Neuromuskulare Erkrankungen; Spinale Muskelatrophie; Duchenne muscular dystrophy; Gene therapy; Neuromuscular diseases; Spinal muscular atrophy Abstract (German): Hintergrund Neuromuskulare Erkrankungen galten lange Zeit als nur symptomatisch behandelbar. Durch neue Technologien konnten in den letzten Jahren erstmals kausale Therapien entwickelt werden. Gentherapien fur die spinale Muskelatrophie, die Duchenne-Muskeldystrophie, die Gliedergurteldystrophien, die myotubulare Myopathie und die hereditare motorisch-sensible Neuropathie Typ 1A werden aktuell in klinischen Studien getestet. Erste Zwischenergebnisse sind Erfolg versprechend und das erste Praparat onasemnogene abeparvovec-xioi (Zolgensma[R]) fur die Therapie der spinalen Muskelatrophie wurde kurzlich von der U.S. Food and Drug Administration (FDA) zugelassen. Ziele Mit diesem Ubersichtsartikel sollen die Wirkungsprinzipien der Gentherapie beschrieben, bisher vorliegende Zwischenergebnisse zusammengefasst und ein Uberblick uber aktive oder in Kurze beginnende Gentherapiestudien geschaffen werden. Diskussion Gentherapien besitzen das Potenzial, den Krankheitsverlauf neuromuskularer Erkrankungen relevant zu beeinflussen. Erste positive Zwischenergebnisse wurden bereits publiziert, die erste Therapie kurzlich in den USA zugelassen. Langzeitdaten uber Nachhaltigkeit und Toxizitat der Gentherapien liegen derzeit noch nicht vor. Die neuen Therapiemoglichkeiten werden das Gesundheitssystem vor neue Herausforderungen bezuglich Diagnostik, Behandlung und Finanzierung stellen. Abstract: Background For a long time the treatment of neuromuscular diseases was considered to be purely symptomatic. Due to new technologies in recent years novel causal forms of treatment could be developed. Gene therapies for spinal muscular atrophy, Duchenne muscular dystrophy, limb-girdle muscular dystrophy, myotubular myopathy and hereditary motor and sensory neuropathy type 1A are currently being evaluated in clinical trials. Initial preliminary results are promising and the first preparation onasemnogene abeparvovec-xioi (Zolgensma[R]) for the treatment of spinal muscular atrophy has recently been approved by the U.S. Food and Drug Administration (FDA). Objective This review describes the principles of gene therapy, summarizes the interim results published so far and provides an overview of currently active or soon to be initiated gene therapy trials. Conclusion Gene therapies have the potential to significantly influence the course of neuromuscular diseases. First positive intermediate results have been published and the first treatment has recently been approved in the USA. Long-term data on sustained effects and toxicity of gene therapies are not yet available. These novel treatment options will present new challenges for the healthcare systems concerning diagnosis, treatment and reimbursement. Author Affiliation: (1) 0000 0001 0328 4908, grid.5253.1, Zentrum fur Kinder- und Jugendmedizin, Sektion fur Neuropadiatrie und Stoffwechselmedizin, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Deutschland (2) 0000 0001 0328 4908, grid.5253.1, Neurologische Klinik, Universitatsklinikum Heidelberg, Heidelberg, Deutschland Article History: Registration Date: 26/06/2019 Online Date: 08/07/2019
    Keywords: Gene Therapy ; Drug Approval ; Genes ; Anopheles
    ISSN: 0028-2804
    E-ISSN: 14330407
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  • 4
    Language: German
    Description: Köln, Univ., Diss., 2009
    Source: Networked Digital Library of Theses and Dissertations
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  • 5
    Language: German
    Description: Thesis (doctoral)--Universität Karlsruhe, 1995 ; 141 p
    Source: Center for Research Libraries
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  • 6
    Language: German
    Description: Purpose: Collagen crimp is essential for maintaining viscoelastic properties of normal ligament and tendon tissue. The actin isoform α-smooth muscle actin (ASMA) has been identified in fibroblastic cells of these tissues. These highly differentiated cells, so called myofibroblasts may transmit tensile forces to the extracellular matrix, thus it has been suggested that they are responsible for the wrinkling of the extracellular matrix and the formation of crimp. During anterior cruciate ligament (ACL) graft remodeling crimp formation plays an integral role. Thus, it was our purpose to determine the relationship between myofibroblast density and crimp frequency in human tendon graft tissue and the ACL. Methods: Different tendon grafts and ACLs were harvested from young human multi organ donors immediately after death. Myofibroblasts were immunostained with a monoclonal antibody and histomorphometry was performed using a digital imaging system. Crimp length was measured and data were correlated. Results: All tendons and ACLs showed a significant correlation of myofibroblast density and crimp frequency (R2 0.81 - 0.43). The strongest correlation was found for the patellar tendon, the poorest for the gracilis tendon. There is also evidence that the phenotype, respectively the shape of myofibroblasts might be responsible for different stages of crimp formation. Conclusion: With the present investigation we found that myofibroblasts might be involved in crimp formation and should be viewed as an integral part of normal tendon and ligament tissue. Furthermore, the shape of myofibroblasts may further indicate the contractile potency of the extracellular matrix, thus presenting a dynamic and variable crimp rather than a static situation. This study is a experimental study. In terms of clinical relevance all the mentioned tendons can be used as auto- or allografts for ACL-reconstruction, nevertheless their microscopic structure and cellular population has yet not been adequately investigated and compared.
    Keywords: 610 Medizin Und Gesundheit ; 610 Medical Sciences; Medicine ; Ddc:610 ; Tendon ; Acl ; Crimp ; Myofibroblast
    Source: Freie Universitat Berlin
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  • 7
    Language: German
    Description: "Wenn Humanität der Nährboden entzogen wird, ist auch die Demokratie in Gefahr." Mit diesem Leitsatz begann die Podiumsdiskussion "Die Flüchtlingskrise als Hersauforderung unserer Demokratie" im Rahmen der bundesweiten Online-Ringvorlesung im Sommersemester 2016 zum Thema "Flucht und Migration - Ursachen und Folgen". Dabei wurden nicht nur Ursachen von Flucht und mögliche bzw. notwendige Konsequenzen unseren Handelns im politischen Raum, sondern auch für die Zivilgesellschaft und die Demokratie als solche diskutiert....
    Keywords: Flüchtlingskrise ; Ringvorlesung ; Ddc 320 / Political Science ; Refugees ; Flucht ; Demokratie
    Source: DataCite
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  • 8
    Language: German
    Keywords: Medizin Und Gesundheit
    Source: DataCite
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  • 9
    Language: German
    Keywords: Umweltanalytik ; Wassernutzung ; Kohlenstoffisotop ; 43.12 Umweltchemie ; 48.58 Pflanzenzüchtung ; 48.34 Bewässerung, Entwässerung ; Chemistry ; Horticulture
    Source: DataCite
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