Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Spanish  (474)
Language
Year
  • 1
    Language: English
    In: Hydrogeology Journal, 2015, Vol.23(6), pp.1217-1227
    Description: Irrigation is essential for achieving food security to the burgeoning global population but unplanned and injudicious expansion of irrigated areas causes waterlogging and salinization problems. Under this backdrop, groundwater resources management is a critical issue for fulfilling the increasing water demand for agricultural, industrial, and domestic uses. Various simulation and optimization approaches were used to solve the groundwater management problems. This paper presents a review of the individual and combined applications of simulation and optimization modeling for the management of groundwater-resource problems associated with irrigated agriculture. The study revealed that the combined use of simulation-optimization modeling is very suitable for achieving an optimal solution for groundwater-resource problems, even with a large number of variables. Independent model tools were used to solve the problems of uncertainty analysis and parameter estimation in groundwater modelling studies. Artificial neural networks were used to minimize the problem of computational complexity. The incorporation of socioeconomic aspects into the groundwater management modeling would be an important development in future studies. L’irrigation est essentielle pour assurer la sécurité alimentaire de la population mondiale en plein essor mais un développement non planifié et non judicieux des zones irriguées provoque des problèmes de colmatage et de salinisation. Dans ce contexte, la gestion des ressources en eaux souterraines est une question cruciale pour satisfaire la demande croissante en eau à des fins agricoles, industrielles et domestiques. Diverses approches de simulation et d’optimisation ont été utilisées pour résoudre les problèmes de gestion des eaux souterraines. Cet article présente une revue des applications simples et combinées des modèles de simulation et d’optimisation pour la gestion des problèmes de ressources en eaux souterraines associés à une agriculture irriguée. L'étude a révélé que l'utilisation combinée de la modélisation de simulation et d'optimisation est très appropriée pour parvenir à une solution optimale pour les problèmes de ressources souterraines, même avec un grand nombre de variables. Des outils de modèle indépendant ont été utilisés pour résoudre les problèmes d’analyse d’incertitude et d’estimation des paramètres dans les études de modélisations des eaux souterraines. Les réseaux de neurones artificiels ont été utilisés pour minimiser le problème de la complexité de calcul. L’incorporation des questions socio-économiques dans les modèles de gestion des eaux souterraines serait un développement important dans les études futures. El riego es fundamental para alcanzar la seguridad alimentaria de una población mundial en crecimiento, pero la expansión no planificada y poco juiciosa de las zonas de riego causa problemas de anegamiento y salinización. Bajo este contexto, la gestión de los recursos hídricos subterráneos es un tema crítico para cumplir con la creciente demanda de agua para usos agrícolas, industriales y domésticos. Se utilizaron diversos enfoques de simulación y de optimización para resolver los problemas de gestión de las aguas subterráneas. Este artículo presenta una revisión de las aplicaciones individuales y combinadas de modelado de simulación y de optimización para la gestión de los problemas de los recursos de las aguas subterráneas asociados con la agricultura bajo riego. El estudio reveló que el uso combinado de modelos de simulación y de optimización es muy adecuado para el logro de una solución óptima para los problemas de los recursos hídricos subterráneos, incluso con un gran número de variables. Se utilizaron herramientas independientes del modelo para resolver los problemas de análisis de incertidumbre y la estimación de parámetros en los estudios de modelización de las aguas subterráneas. Las redes neuronales artificiales se utilizan para minimizar el problema de la complejidad computacional. La incorporación de los aspectos socioeconómicos en el modelado de la gestión de las aguas subterráneas sería un importante desarrollo en los futuros estudios. 面对世界人口的迅速增长,灌溉对于实现粮食安全必不可少,然而,灌溉区无计划的和草率的扩张导致了水涝和盐碱化问题。在此背景下,地下水资源管理是实现和增加农业、工业和家庭用水需求的重要一环。使用了各种模拟和最优化方法解决地下水管理问题。本文论述了与灌溉农业有关的地下水资源问题管理单个和组合的模拟应用和最优化模拟。研究揭示,模拟-最优化模拟的联合应用对于实现地下水资源问题的最优化解决非常适合,即使这些问题具有大量的变量。利用独立的模型工具解决地下水模拟研究中不确定分析问题和参数估算问题。采用人工神经网络使计算复杂性的问题减少到最小。把社会经济方面等因素纳入到地下水管理模拟中将是未来研究中的重点。 A irrigação é essencial para alcançar a segurança alimentar para a população global crescente, mas a expansão não planejada e imprudente de áreas irrigadas causa problemas de encharcamento e salinização. Sob esse pano de fundo, o gerenciamento de recursos hídricos subterrâneos é uma questão crítica para a satisfação da crescente demanda de água para usos agrícolas, industriais e domésticos. Várias abordagens de simulação e otimização foram usadas para resolver os problemas de gestão das águas subterrâneas. Este trabalho apresenta uma revisão das aplicações individuais e combinadas de modelagem de simulação e otimização para a gestão de problemas de recursos hídricos subterrâneos associados com a agricultura irrigada. O estudo revelou que o uso combinado de modelagem de simulação-otimização é muito adequado para alcançar uma solução ideal para os problemas de recursos hídricos subterrâneos, mesmo com um grande número de variáveis. Ferramentas de modelagem independentes foram usadas para resolver os problemas de análise de incerteza e de estimação de parâmetros em estudos de modelagem de águas subterrâneas. Redes neurais artificiais foram usadas para minimizar o problema da complexidade computacional. A incorporação de aspectos socioeconômicos para a modelagem da gestão de águas subterrâneas seria um desenvolvimento importante em estudos futuros.
    Keywords: Groundwater management ; Simulation ; Optimization ; Agriculture ; Waterlogging
    ISSN: 1431-2174
    E-ISSN: 1435-0157
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: International Journal of Oncology, January 2012, Vol.40(1), pp.99-108
    Description: Optimized purification of oligomeric proanthocyanidines (PAC) from cranberry generated PAC-1A which selectively affected the viability of various neuroblastoma (NB) cell lines representing a spectrum of high-risk NB features. PAC-1A caused a loss of mitochondrial transmembrane depolarization potential (∆Ψm) and increased generation of reactive oxygen species (ROS) which was directly correlated to the modulation of apoptotic marker proteins in SMS-KCNR cells. PAC-1A reduced the expression of pro-survival (Bcl-2, MCL-1, Bcl-xL) and increased levels of pro-apoptotic (Bax, Bad, Bid) Bcl family proteins, upregulated the activity of SAPK/JNK MAPK and downregulated expression or activity of PI3K/AKT/mTOR pathway components. PAC-1A increased the cellular uptake/retention of cyclophosphamide (CP). PAC-1A and CP synergistically increased cytotoxicity and expression of pro-apoptotic markers, reduced cellular glutathione (GSH) and superoxide dismutase (SOD) levels. Additional features of PAC-1A as an anticancer drug as shown in SMS-KCNR NB cells include delay of cell cycle progression and induction of cell death via TNF-family death receptor activity, thus, targeting both the extrinsic and intrinsic pathway of apoptosis. PAC-1A partially blocked the cell cycle in G2/M phase which correlated with a decrease of the G0/G1 subpopulation, upregulation of cyclin D1 and downregulation of CDK6 and p27 expression. In summary, PAC-1A has demonstrated chemotherapeutic potential to treat a broad spectrum of NBs including highly malignant tumors that show resistance to standard chemotherapeutics and apoptotic stimuli.
    Keywords: Surgical Stapler;
    ISSN: 1019-6439
    E-ISSN: 17912423
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: Hydrogeology Journal, 2011, Vol.19(7), pp.1421-1429
    Description: The ever increasing demand for freshwater and overexploitation of existing reserves has necessitated the search for new resources, particularly in hard-rock terrains where groundwater is a vital and sole source for drinking and other activities. A fast and cost effective way of groundwater exploration is the study and analysis of remote sensing data. In the present study, various geomorphic units in the drought-prone and hard-rock-dominated Gwalior area, India, were identified using satellite images and classified into four categories: poor, moderate, good and excellent groundwater prospect zones. The area was scanned through vertical electrical soundings for the corroboration of inferred categories. The borehole yield data corroborate the results. Geomorphological mapping through satellite images, coupled with electrical resistivity surveys, provided vital information about spatial and depth-wise variation of aquifers in the area. Groundwater prospect mapping gives a rational picture of subsurface water resources and is helpful in predictive groundwater resource management. La demande en eau douce toujours croissante et la surexploitation des réserves existantes ont conduit à la recherche de ressources nouvelles, notamment dans le socle où les eaux souterraines constituent une source vitale et unique pour la boisson et les autres usages. Un moyen rapide et rentable d’exploration des eaux souterraines est l’étude et l’analyse des données de télédétection. Dans l’étude présentée, diverses unités géomorphologiques du secteur de Gwalior, en Inde, secteur sujet à la sècheresse et dominé par le socle, ont été identifiées au moyen d’images satellitaires et classifiées en quatre catégories de zone de potentiel en eaux souterraines : pauvre, modeste, bonne et excellente. Le secteur a été balayé par des sondages électriques verticaux pour confirmer les catégories ainsi déduites. Les données de débit des forages corroborent les résultats. La cartographie géomorphologique au moyen d’images satellitaires, associée à des levés de résistivité électrique, fournit une information essentielle sur les variations spatiales et en profondeur des aquifères de la zone. La cartographie des potentialités en eaux souterraines donne une image rationnelle des ressources en eau de sub-surface et est utile pour une gestion prédictive de la ressource en eaux souterraines. La siempre creciente demanda de agua dulce y la sobreexplotación de las reservas existentes han requerido la búsqueda de nuevos recursos, particularmente en terrenos de rocas duras donde el agua subterránea es una fuente vital y única para agua potable y otras actividades. Una forma rápida y de bajo costo de exploración del agua subterránea es el estudio y análisis de los datos de sensores remotos. En el presente estudio, se identificaron varias unidades geomórficas en el área Gwalior, propensa a las sequías y dominada por rocas duras, usando imágenes satelitales y fueron clasificadas en cuatro categorías de zonas: pobres, moderadas, buenas y excelentes en relación a la prospección de agua subterránea: El área fue explorada mediante sondeos eléctricos verticales para corroborar las categorías inferidas. Los datos de rendimiento de las perforaciones corroboraron los resultados. El mapeo geomorfológico a través de imágenes satelitales, en conjunción con los relevamientos de resistividad eléctrica proveyó información vital acerca del modo de variación espacial y en profundidad de los acuíferos en el área. El mapeo de la prospección de agua subterránea da una imagen racional de los recursos de agua en el subsuelo y es una ayuda en el manejo de la predicción del recurso de agua subterránea. 对淡水的持续需求和已有水资源的过量开采使特别是在基岩山区寻找新的水资源变得非常必要,因为在这些地区地下水是饮用水和其他供水的重要且唯一的来源。基于遥感数据的研究和分析方法是地下水勘探的快速、经济、有效的方法。在本研究中,我们利用卫星影像识别出干旱和基岩出露为特征的印度Gwalior地区的地貌单元,并将它们分为四类:贫瘠的,中等的,好的和非常好的地下水资源远景区。采用垂向电测深方法对该分区提供了提供佐证。钻孔抽水量数据也验证了以上结果。利用卫星影像进行的地貌成图耦合电阻率调查方法给该地区面上和垂向上的含水层变化提供了重要的信息。地下水资源远景区制图给出了地下水资源的合理分布且有利于基于预测的地下水资源管理。 A sempre crescente necessidade de água doce e a sobre-exploração das reservas existentes tornou necessária a procura de novos recursos, particularmente em rochas fraturadas, onde a água subterrânea é uma origem vital e única para água potável e outras actividades. Uma forma de prospeção de águas subterrâneas rápida e com custo eficaz é através do estudo e análise de dados de detecção remota. No estudo apresentado identificaram-se e classificaram-se, utilizando imagens de satélite, várias unidades geomórficas na área árida dominada por rochas fraturadas de Gwalior, Índia, em quatro categorias: zonas de prospecção de águas subterrâneas fracas, moderadas, boas e excelentes. A área foi examinada por sondagens eléctricas verticais para a corroboração das categorias inferidas. As produtividades dos furos corroboram os resultados. O mapeamento geomorfológico através das imagens de satélite, associado aos levantamentos de resistividade eléctrica, forneceu informação vital sobre a variação espacial e em profundidade dos aquíferos da área. O mapeamento prospectivo de águas subterrâneas dá uma imagem racional dos recursos hídricos subsuperficiais e é útil na previsão da gestão dos recursos hídricos subterrâneos. बढतें ताजे पानी की मांग और अतिदोहन के कारण नये संसाधनों की खोज विद्गोष रूप से उन क्षेत्रो मे जहा प्रभ्ूत्व कठोर चट्‌टाने है। उन क्षेत्रों मे पीने एवं अन्य गतिविधियों का साधन भूजल है। अतः उन क्षेत्रों में प्रभावी एवं तेज तरीके से नये भूजल क्ष़्ाोतो की खोज में सूदर संवेदन डेटा का उपयोग एवं उनका विद्गलेषण करने का मुखया साधन है। प्रस्तुत अध्ययन में ग्वालियर क्षेत्र के सुखा प्रवण क्षेत्र के विभिन्न भूआकृति इकाईयो को उपग्रह चित्रो से पहचाना गया है और उनको चार इकाईयों में विभाजित किया गया है जो क्रमद्गाःगरीब, मध्यम, अच्छा, और उत्कृष्ट सम्भावित क्षेत्र है। इन प्राप्त भूजल इकाइयों की विद्युत प्रतिरोधन सर्वेक्षण के द्वारा भी पूष्टि की गई है। इन सब प्राप्त भूजल आकडो की बोर होल डाटा के परीणाम से भी पुष्टि की गई है। भूआकृति मानचित्रण, सूदूर संवेदन डाटा, एवं विद्युत प्रतिरोधक संर्वेक्षण एक साथ मिलकर ग्वालियर क्षेत्र के स्थानिक एवं गहराई में परिवर्तन के बारे में महत्वपूर्ण जानकारी प्रदान की है। भूजल संभावना मानचित्रण, उपसतह जल संसाधनो की एक तर्क संगत तस्वीर देता है जिसका उपयोग भूजल संसाधन मूल्याकन एवं प्रबंधन में सहायक है।
    Keywords: Groundwater prospect ; Remote sensing ; Geomorphology ; Resistivity ; India
    ISSN: 1431-2174
    E-ISSN: 1435-0157
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: Gender, Place & Culture, 07 February 2015, Vol.22(2), pp.222-238
    Description: One of the stated goals of microfinance programs is to increase the bargaining power of women within the household. However, little is known about other ways women in patriarchal communities may be affected by these programs. This study assessed the effects of the membership in a microfinance...
    Keywords: Indian Women ; Microfinance ; Social Networks ; Gender Norms ; Qualitative ; Sociology ; Mujeres Indias ; Microfinanzas ; Redes Sociales ; Normas de Género ; Cualitativo ; Sociología ; 印度女性 ; 小额信贷
    ISSN: 0966-369X
    E-ISSN: 1360-0524
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: Portuguese
    In: Atmósfera, 01 January 2012, Vol.25(1), pp.43-63
    Description: The aim of this study is to capitalize on the spatial detail of Landsat and the temporal regularity of MODIS acquisitions using a fusion approach (Spatial and Temporal Adaptive Reflectance Fusion Model, STARFM). Specifically, the 30 m Landsat-7 ETM+ (Enhanced Thematic Mapper plus) surface reflectance was predicted for a period of eight years (2002-2009) as the product of observed ETM+ and MODIS surface reflectance (MOD09Q1) on the predicted and observed ETM+ dates. A pixel based analysis for observed ETM+ dates covering winter and summer crop seasons showed that the prediction method was more accurate for NIR (mean r² = 0.87, p ≤ 0.01) compared to red band (mean r² = 0.65; p ≤ 0.01). The NDVI was computed from observed Landsat and predicted surface reflectance. The difference between NDVI from predicted and observed ETM+ data (prediction residual) was compared with the temporal residuals of NDVI from observed Landsat and MODIS data at two different dates. The prediction residuals for NDVI (spatial mean value of 0.0085) were found to be significantly lower than the temporal residuals (spatial mean value of 0.056 for MODIS and 0.051 for observed ETM+) implying that the prediction method was better than temporal pixel substitution. Investigating the trend in synthetic ETM+ NDVI values over a growing season revealed that phenological patterns were well captured. A direct comparison between the NDVI values obtained from MODIS and synthetic ETM+ images has shown a good consistency of the temporal dynamics but a systematic error that can be read as bias (MODIS NDVI over estimation). The relationship between synthetic ETM+ NDVI with observed precipitation and evaporation data was also studied and it was observed that monthly total precipitation and monthly evaporation of the preceding month have higher correlation coefficients (r² = 0.56 and r² = 0.59) with mean monthly synthetic ETM+ NDVI.
    Keywords: Meteorology & Atmospheric Sciences ; Landsat ; Modis ; Blending ; Ndvi ; Precipitation ; Evaporation ; Meteorology & Climatology
    ISSN: 0187-6236
    Source: SciELO
    Source: SciELO Mexico
    Source: SciELO Complete
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: Journal of Visual Art Practice, 01 January 2011, Vol.10(1), pp.35-50
    Description: This article is based on the findings of an ethnographic field research conducted at Sudarshan Layout, an urban slum in Bangalore, India in February 2009. The research was participatory in nature and was conducted in collaboration with Ambedkar Community Computing Center (AC3), a group consisting...
    Keywords: Boundary Objects ; Participatory Research Ethnographic Action Research ; Participatory Rural Appraisal ; Visual Artefacts ; Indian Urban Slums ; Visual Arts
    ISSN: 1470-2029
    E-ISSN: 1758-9185
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: International Journal of Oncology, August 2011, Vol.39(2), pp.373-381
    Description: Ovarian carcinoma is the most lethal gynecological malignancy among women and its poor prognosis is mainly due to metastasis. Chemokine receptor CCR9 is primarily expressed by a small subset of immune cells. The interactions between CCL25 and CCR9 have been implicated in leukocyte trafficking to the small bowel, a frequent metastatic site for ovarian cancer cells. We have previously shown that ovarian cancer cells express CCR9 and play an important role in cell migration, invasion and survival in the presence of its natural ligand in vitro. In this study, we have evaluated the expression of CCR9 and CCL25 in ovarian cancer cells and clinical samples. Ovarian cancer tissue microarrays from University of Alabama at Birmingham and AccuMax were stained for CCR9 and CCL25. Aperio ScanScope was used to acquire 80X digital images and expression analysis of CCR9 and CCL25. Flow cytometry and the Image stream system were used to conform the expression of CCR9 and CCL25 in ovarian cancer cells. Our results show significantly higher (p〈0.001) expression of CCR9 and CCL25 in serous adenocarcinoma followed by serous papillary cystadenoma, endometrioid adenocarcinoma, mucinous adenocarcinoma, cystadenoma, mucinous boderline adenocarcinoma, clear cell carcinoma, granulosa cell tumor, dysgerminoma, transitional cell carcinoma, Brenner tumor, yolk sac tumor, adenocarcinoma and fibroma cases, compared to non-neoplastic ovarian tissue. Similar to tissue expression, CCR9 was also significantly expressed by the ovarian cancer cell lines (OVCAR-3 and SK-OV-3) in comparison to normal adult ovarian epithelial cell. We provide the first evidence that CCR9 and its natural ligand CCL25 are highly expressed by ovarian cancer tissue and their expression correlates with histological subtypes. Expression of this chemokine receptor and its ligand CCL25 within primary tumor tissue further suggests a potential role of this chemokine-receptor axis in ovarian cancer progression.
    Keywords: Surgical Stapler;
    ISSN: 1019-6439
    E-ISSN: 17912423
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Revista Médica Clínica Las Condes, 01 July 2012, Vol.23(4), pp.504-505
    Description: BACKGROUNDOsteoarthritis, a common joint disorder, is one of the leading causes of disability. Chondroitin has emerged as a new treatment. Previous meta-analyses have shown contradictory results on the efficacy of chondroitin. This, in addition to the publication of more trials, necessitates a systematic review. OBJECTIVESTo evaluate the benefit and harm of oral chondroitin for treating osteoarthritis compared with placebo or a comparator oral medication including, but not limited to, nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics, opioids, and glucosamine or other "herbal" medications. SEARCH METHODSWe searched seven databases up to November 2013, including the Cochrane Central Register of Controlled Trials (CENTRAL), Ovid MEDLINE, CINAHL, EMBASE, Science Citation Index (Web of Science) and Current Controlled Trials. We searched the US Food and Drug Administration (FDA) and European Medicines Agency (EMEA) websites for adverse effects. Trial registers were not searched. SELECTION CRITERIAAll randomized or quasi-randomized clinical trials lasting longer than two weeks, studying adults with osteoarthritis in any joint, and comparing chondroitin with placebo, an active control such as NSAIDs, or other "herbal" supplements such as glucosamine. DATA COLLECTION AND ANALYSISTwo review authors independently performed all title assessments, data extractions, and risk of bias assessments. MAIN RESULTSForty-three randomized controlled trials including 4,962 participants treated with chondroitin and 4,148 participants given placebo or another control were included. The majority of trials were in knee OA, with few in hip and hand OA. Trial duration varied from 1 month to 3 years. Participants treated with chondroitin achieved statistically significantly and clinically meaningful better pain scores (0-100) in studies less than 6 months than those given placebo with an absolute risk difference of 10% lower (95% confidence interval (CI), 15% to 6% lower; number needed to treat (NNT) = 5 (95% CI, 3 to 8; n = 8 trials) (level of evidence, low; risk of bias, high); but there was high heterogeneity between the trials (T(2) = 0.07; I(2) = 70%, which was not easily explained by differences in risk of bias or study sample size). In studies longer than 6 months, the absolute risk difference for pain was 9% lower (95% CI 18% lower to 0%); n = 6 trials; T(2) = 0.18; I(2) = 83% ), again with low level of evidence.For the Western Ontario and McMaster Universities Osteoarthritis Index Minimal Clinically Important Improvement (WOMAC MCII Pain subscale) outcome, a reduction in knee pain by 20% was achieved by 53/100 in the chondroitin group versus 47/100 in the placebo group, an absolute risk difference of 6% (95% CI 1% to 11%), (RR 1.12, 95% CI 1.01 to 1.24; T(2) = 0.00; I(2) = 0%) (n = 2 trials, 1253 participants; level of evidence, high; risk of bias, low).Differences in Lequesne's index (composite of pain,function and disability) statistically significantly favoured chondroitin as compared with placebo in studies under six months, with an absolute risk difference of 8% lower (95% CI 12% to 5% lower; T(2)= 0.78; n = 7 trials) (level of evidence, moderate; risk of bias, unclear), also clinically meaningful. Loss of minimum joint space width in the chondroitin group was statistically significantly less than in the placebo group, with a relative risk difference of 4.7% less (95% CI 1.6% to 7.8% less; n = 2 trials) (level of evidence, high; risk of bias, low). Chondroitin was associated with statistically significantly lower odds of serious adverse events compared with placebo with Peto odds ratio of 0.40 (95% CI 0.19 to 0.82; n = 6 trials) (level of evidence, moderate). Chondroitin did not result in statistically significant numbers of adverse events or withdrawals due to adverse events compared with placebo or another drug. Adverse events were reported in a limited fashion, with some studies providing data and others not.Comparisons of chondroitin taken alone or in combination with glucosamine or another supplement showed a statistically significant reduction in pain (0-100) when compared with placebo or an active control, with an absolute risk difference of 10% lower (95% CI 14% to 5% lower); NNT = 4 (95% CI 3 to 6); T(2) = 0.33; I(2) = 91%; n = 17 trials) (level of evidence, low). For physical function, chondroitin in combination with glucosamine or another supplement showed no statistically significant difference from placebo or an active control, with an absolute risk difference of 1% lower (95% CI 6% lower to 3% higher with T(2) = 0.04; n = 5 trials) (level of evidence, moderate). Differences in Lequesne's index statistically significantly favoured chondroitin as compared with placebo, with an absolute risk difference of 8% lower (95% CI, 12% to 4% lower; T(2) = 0.12; n = 10 trials) (level of evidence, moderate). Chondroitin in combination with glucosamine did not result in statistically significant differences in the numbers of adverse events, withdrawals due to adverse events, or in the numbers of serious adverse events compared with placebo or with an active control.The beneficial effects of chondroitin in pain and Lequesne's index persisted when evidence was limited to studies with adequate blinding or studies that used appropriate intention to treat (ITT) analyses. These beneficial effects were uncertain when we limited data to studies with appropriate allocation concealment or a large study sample (〉 200) or to studies without pharmaceutical funding. AUTHORS' CONCLUSIONSA review of randomized trials of mostly low quality reveals that chondroitin (alone or in combination with glucosamine) was better than placebo in improving pain in participants with osteoarthritis in short-term studies. The benefit was small to moderate with an 8 point greater improvement in pain (range 0 to 100) and a 2 point greater improvement in Lequesne's index (range 0 to 24), both seeming clinically meaningful. These differences persisted in some sensitivity analyses and not others. Chondroitin had a lower risk of serious adverse events compared with control. More high-quality studies are needed to explore the role of chondroitin in the treatment of osteoarthritis. The combination of some efficacy and low risk associated with chondroitin may explain its popularity among patients as an over-the-counter supplement.
    Keywords: Anti-Inflammatory Agents, Non-Steroidal–Therapeutic Use ; Chondroitin Sulfates–Therapeutic Use ; Glucosamine–Therapeutic Use ; Hand–Drug Therapy ; Humans–Drug Therapy ; Osteoarthritis–Drug Therapy ; Osteoarthritis, Hip–Drug Therapy ; Osteoarthritis, Knee–Drug Therapy ; Pain Measurement–Drug Therapy ; Randomized Controlled Trials As Topic–Drug Therapy ; Anti-Inflammatory Agents, Non-Steroidal ; Chondroitin Sulfates ; Glucosamine;
    ISSN: 0716-8640
    ISSN: 1469493X
    E-ISSN: 1469493X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: Spanish
    In: Agronomía Mesoamericana, 01 May 2016, Vol.9(1)
    Description: El objetivo fue describir requerimientos básicos y métodos alternativos de selección para el mejoramiento simultáneo en frijol común, en el tiempo más corto posible y considerando el máximo número de caracteres agronómicos. Esta estrategia incluye: (1) obtener claridad sobre la importancia y problemática del cultivo de frijol para la zona, (2) fijar objetivos y prioridades del mejoramiento genético, (3) identificar y usar únicamente padres que con absoluta confianza pueden considerarse donantes de genes necesarios, (4) utilizar cruzamientos múltiples con un número adecuado de polinizaciones para producir suficiente semilla de cada cruza, (5) realizar evaluación y selección para marcadores actualmente disponibles (e.g., para gorgojo, mosaico común, mosaico dorado, antracnosis, picudo, bacteriosis común y roya, entre otros) desde la etapa de hibridación, (6) métodos alternativos de selección; como selección de gametos y descendiente de semilla única (SG-DSU), selección de gametos y pedigrí usando marcadores (SG-PUM), selección de gametos y evaluación y selección agronómica de familias en generaciones tempranas (SG-EAF), o una combinación e integración de los métodos SG-PUM y SG-EAF; y (7) conseguir una estrecha y genuina colaboración e integración de actividades de mejoramiento entre diferentes investigadores a nivel de instituciones, países y la región entera, en localidades claves, para efectuar evaluaciones confiables de viveros de frijol a efectos de realizar selección simultánea para el máximo número de caracteres agronómicos.
    E-ISSN: 2215-3608
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Article
    Article
    Language: Spanish
    In: Medicina Clinica, 07 July 2017, Vol.149(1), pp.e5-e5
    Keywords: Medicine
    ISSN: 0025-7753
    E-ISSN: 15788989
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages