Format:
Online-Ressource
ISSN:
2192-2659
Content:
Abstract: Small frame nucleic acids (FNAs) serve as excellent carrier materials for various functional nucleic acid molecules, showcasing extensive potential applications in biomedicine development. The carrier module and function module combination is crucial for probe design, where an improper combination can significantly impede the functionality of sensing platforms. This study explores the effect of various combinations on the sensing performance of nanodevices through simulations and experimental approaches. Variances in response velocities, sensitivities, and cell uptake efficiencies across different structures are observed. Factors such as the number of functional molecules loaded, loading positions, and intermodular distances affect the rigidity and stability of the nanostructure. The findings reveal that the structures with full loads and moderate distances between modules have the lowest potential energy. Based on these insights, a multisignal detection platform that offers optimal sensitivity and response speed is developed. This research offers valuable insights for designing FNAs‐based probes and presents a streamlined method for the conceptualization and optimization of DNA nanodevices.
In:
day:15
In:
month:10
In:
year:2023
In:
extent:9
In:
Advanced healthcare materials, Weinheim : Wiley-VCH, [2012]-, (15.10.2023) (gesamt 9), 2192-2659
Language:
English
DOI:
10.1002/adhm.202302652
URN:
urn:nbn:de:101:1-2023101615181355008647
URL:
https://doi.org/10.1002/adhm.202302652
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023101615181355008647
URL:
https://d-nb.info/1306223792/34
URL:
https://doi.org/10.1002/adhm.202302652
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