Format:
Online-Ressource
ISSN:
1432-1831
Content:
The human immunodeficiency virus (HIV) had spread unrecognized in the human population as sexually transmitted disease and was finally identified by its disease AIDS in 1981. Even after the isolation of the causative agent in 1983, the burden and death rate of AIDS accelerated worldwide especially in young people despite the confection of new drugs capable to inhibit virus replication since 1997. However, at least in industrialised countries, this trend could be reversed by the introduction of combination therapy strategies. The design of new drugs is on going; besides the inhibition of the three enzymes of HIV for replication and maturation (reverse transcriptase, integrase and protease), further drugs inhibits fusion of viral and cellular membranes and virus maturation. ...
In:
Medical microbiology and immunology, Berlin : Springer, 1886-, Band 198, Heft 3 (2009), Seite 147-155, 1432-1831
In:
volume:198
In:
year:2009
In:
number:3
In:
pages:147-155
In:
extent:9
Language:
English
DOI:
10.1007/s00430-009-0117-6
URN:
urn:nbn:de:hebis:30:3-301262
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