Format:
Online-Ressource
ISSN:
1932-6203
Content:
Insertion of bone substitution materials accelerates healing of osteoporotic fractures. Biodegradable materials are preferred for application in osteoporotic patients to avoid a second surgery for implant replacement. Degraded implant fragments are often absorbed by macrophages that are removed from the fracture side via passage through veins or lymphatic vessels. We investigated if lymphatic vessels occur in osteoporotic bone defects and whether they are regulated by the use of different materials. To address this issue osteoporosis was induced in rats using the classical method of bilateral ovariectomy and additional calcium and vitamin deficient diet. In addition, wedge-shaped defects of 3, 4, or 5 mm were generated in the distal metaphyseal area of femur via osteotomy. ...
In:
PLOS ONE, San Francisco, California, US : PLOS, 2006-, Band 8, Heft 10 (2013), 1932-6203
In:
volume:8
In:
year:2013
In:
number:10
In:
extent:15
Language:
English
DOI:
10.1371/journal.pone.0077259
URN:
urn:nbn:de:hebis:30:3-317842
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