Format:
Online-Ressource
ISSN:
1615-9861
Content:
Abstract: A novel strain of influenza A H1N1 emerged in the spring of 2009 and has spread rapidly throughout the world. Although vaccines have recently been developed that are expected to be protective, their availability was delayed until well into the influenza season. Although anti‐influenza drugs such as neuraminidase inhibitors can be effective, resistance to these drugs has already been reported. Although human saliva was known to inhibit viral infection and may thus prevent viral transmission, the components responsible for this activity on influenza virus, in particular, influenza A swine origin influenza A virus (S‐OIV), have not yet been defined. By using a proteomic approach in conjunction with beads that bind α‐2,6‐sialylated glycoprotein, we determined that an α‐2‐macroglobulin (A2M) and an A2M‐like protein are essential components in salivary innate immunity against hemagglutination mediated by a clinical isolate of S‐OIV (San Diego/01/09 S‐OIV). A model of an A2M‐based “double‐edged sword” on competition of α‐2,6‐sialylated glycoprotein receptors and inactivation of host proteases is proposed. We emphasize that endogenous A2M in human innate immunity functions as a natural inhibitor against S‐OIV.
In:
volume:10
In:
number:12
In:
year:2010
In:
pages:2396-2401
In:
extent:6
In:
Proteomics, Weinheim : Wiley VCH, [2001]-, 10, Heft 12 (2010), 2396-2401 (gesamt 6), 1615-9861
Language:
English
DOI:
10.1002/pmic.200900775
URN:
urn:nbn:de:101:1-2023042805241106066681
URL:
https://doi.org/10.1002/pmic.200900775
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023042805241106066681
URL:
https://d-nb.info/1287262503/34
URL:
https://doi.org/10.1002/pmic.200900775
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