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  • Serial component part  (6)
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  • Serial component part  (6)
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  • 1
    Online Resource
    Online Resource
    Gene expression profiling of maternal blood in early onset severe preeclampsia: identification of novel biomarkers (2009)
    Berlin : Kooperation de Gruyter
    Details
    UID:
    (DE-602)edochu_18452_12050
    ISSN: 1619-3997 , 1619-3997
    Content: Aims: To investigate candidate genes in peripheral blood mononuclear cell (PBMC) that are associated with early onset severe preeclampsia (ES-PE) and to describe candidate genes function using microarrays and real-time polymerase chain reaction (PCR). Methods: PBMC RNA was extracted from six patients with ES-PE and five uncomplicated pregnancies. The HG_U133 plus 2.0 Affymetrix GeneChips that represented 47,000 genes were used to measure gene expression in each sample. Significance analysis of microarray identified potential signature genes characterizing ES-PE vs. uncomplicated pregnancies. Eight genes were selected for confirmation by real-time PCR of 32 patients with ES-PE and 24 uncomplicated pregnancies, matched for maternal age, parity, race and gestational weeks. Results: Using a whole-genome approach to study the molecular determinants of ES-PE, 72 genes were found to be differentially expressed between cases and controls, including 38 up-regulated genes and 34 down-regulated genes in the group of ES-PE. Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 (KIR3DL2), aldo-keto reductase family 1, member C3 (AKR1C3), churchill domain containing 1 (CHURC1), and solute carrier family 25, member 13 (SLC25A13) were validated to be down-regulated in the patients with ES-PE by real-time PCR. Conclusions: Expression of genes with diverse function is associated with ES-PE risk, providing opportunities for the development of non-invasive diagnosis.
    Content: Peer Reviewed
    In: Journal of Perinatal Medicine, : de Gruyter, 2009, 37,2009,6, Seiten 609-616, 1619-3997
    Language: Undetermined
    DOI: 10.1515/JPM.2009.103
    DOI: 10.18452/11398
    URN: urn:nbn:de:kobv:11-100142882
    URL: Volltext  (kostenfrei)
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    HU Berlin
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  • 2
    Online Resource
    Online Resource
    A Universal Synthesis Strategy for Tunable Metal‐Organic Framework Nanohybrids (2023)
    Berlin : Humboldt-Universität zu Berlin
    Details
    UID:
    (DE-602)edochu_18452_27710
    Format: 1 Online-Ressource (8 Seiten)
    ISSN: 1433-7851 , 1521-3773 , 1433-7851 , 1521-3773
    Content: Metal-organic frameworks (MOFs) with encapsulated nanoparticles (NPs) enjoy a vastly expanded application potential in catalysis, filtration, and sensing. The selection of particular modified core-NPs has yielded partial successes in overcoming lattice mismatch. However, restrictions on the choice of NPs not only limit the diversity, but also affect the properties of the hybrid materials. Here, we show a versatile synthesis strategy using a representative set of seven MOF-shells and six NP-cores that are fine-tuned to incorporate from single to hundreds of cores in mono-, bi-, tri- and quaternary composites. This method does not require the presence of any specific surface structures or functionalities on the pre-formed cores. Our key point is to regulate the diffusion rate of alkaline vapors that deprotonate organic linkers and trigger the controlled MOF-growth and encapsulation of NPs. This strategy is expected to pave the way for the exploration of more sophisticated MOF-nanohybrids.
    Content: Peer Reviewed
    In: Weinheim : Wiley-VCH, 62,21, 1433-7851
    In: 1521-3773
    Language: English
    DOI: 10.1002/anie.202301021
    DOI: 10.18452/27018
    URN: urn:nbn:de:kobv:11-110-18452/27710-4
    URL: Volltext  (kostenfrei)
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    HU Berlin
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  • 3
    Online Resource
    Online Resource
    Self‐assembly Mechanism and Chiral Transfer in CuO Superstructures (2023)
    Berlin : Humboldt-Universität zu Berlin
    Details
    UID:
    (DE-602)edochu_18452_27830
    Format: 1 Online-Ressource (9 Seiten)
    ISSN: 1433-7851 , 1521-3773 , 1433-7851 , 1521-3773
    Content: Chiral inorganic superstructures have received considerable interest due to the chiral communication between inorganic compounds and chiral organic additives. However, the demanding fabrication and complex multilevel structure seriously hinder the understanding of chiral transfer and self‐assembly mechanisms. Herein, we use chiral CuO superstructures as a model system to study the formation process of hierarchical chiral structures. Based on a simple and mild synthesis route, the time‐resolved morphology and the in situ chirality evolution could be easily followed. The morphology evolution of the chiral superstructure involves hierarchical assembly, including primary nanoparticles, intermediate bundles, and superstructure at different growth stages. Successive redshifts and enhancements of the CD signal support chiral transfer from the surface penicillamine to the inorganic superstructure. Full‐field electro‐dynamical simulations reproduced the structural chirality and allowed us to predict its modulation. This work opens the door to a large family of chiral inorganic materials where chiral molecule‐guided self‐assembly can be specifically designed to follow a bottom‐up chiral transfer pathway.
    Content: Peer Reviewed
    In: Weinheim : Wiley-VCH, 62,27, 1433-7851
    In: 1521-3773
    Language: English
    DOI: 10.1002/anie.202305353
    DOI: 10.18452/27167
    URN: urn:nbn:de:kobv:11-110-18452/27830-1
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    HU Berlin
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  • 4
    Online Resource
    Online Resource
    Chromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese (2009)
    Berlin : Kooperation de Gruyter
    Details
    UID:
    (DE-602)edochu_18452_13597
    ISSN: 1437-4331 , 1437-4331
    Content: Background: rs1333049 polymorphism on chromosome 9p21 has been shown to affect susceptibility to coronary artery disease (CAD) in Caucasians. This study examined the association of rs1333049 with myocardial infarction (MI), angiographic severity of CAD and clinical outcome after a first acute MI in Han Chinese. Methods: rs1333049 polymorphism was genotyped in 520 patients with a first acute MI and in 560 controls. The number of angiographically documented diseased coronary arteries (luminal diameter stenosis ≥50%), echocardiographic left ventricular ejection fraction (LVEF), and major adverse cardiac events (MACE) during follow-up (mean, 29±15 months) were recorded. Results: Patients with MI had higher frequencies of the CC genotype (30.0% vs. 20.7%) or C allele (55.5% vs. 46.2%) compared with controls (all p<0.01). rs1333049 polymorphism was strongly associated with MI [odds ratio (OR) 1.48, 95% confidence interval (CI) 1.22–1.79] after adjusting for traditional risk factors. Although longer hospitalization stay was observed in patients with the rs1333049-C allele, this polymorphism was not related to angiographic severity of CAD, LVEF, and occurrence of MACE after MI. Conclusions: This study demonstrates an association of rs1333049 polymorphism locus on chromosome 9p21 with risk for MI, but not with post-MI prognosis in Han Chinese. Clin Chem Lab Med 2009;47:917–22.
    Content: Peer Reviewed
    In: Clinical Chemistry and Laboratory Medicine, : de Gruyter, 2009, 47,2009,8, Seiten 917-922, 1437-4331
    Language: Undetermined
    DOI: 10.1515/CCLM.2009.215
    DOI: 10.18452/12945
    URN: urn:nbn:de:kobv:11-100165701
    URL: Volltext  (kostenfrei)
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    HU Berlin
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  • 5
    Online Resource
    Online Resource
    Ti-Doped SnO 2 Supports IrO 2 Electrocatalysts for the Oxygen Evolution Reaction (OER) in PEM Water Electrolysis (2023)
    Details
    UID:
    (DE-101)1288349424
    Format: Online-Ressource
    Content: The development of polymer electrolyte membrane electrolysis of water is mainly limited by the high cost of noble metals and inadequate stability owing to the slow reaction kinetics of the oxygen evolution reaction and the restrictions of strongly acidic operating environments. To improve the utilization of noble metals, we use Ti-doped SnO 2 as a carrier to support active species IrO 2 . The results show that the introduction of Ti element can inhibit the grain growth and help to improve the electrical conductivity of SnO 2 . Electrochemical tests for the catalysts show that 40 wt % IrO 2 /TSO has the best mass-normalized charge (231.24 C g –1 IrO 2 ) and current density (714.85 A g –1 IrO 2 ) at 1.6 V with the overpotential of only 271 mV at 10 mA cm –2 , which is attributed to the outstanding dispersion effect of Ti-doped SnO 2 and the synergy between the active species and the introduction of Ti element. The comprehensive advantages exhibited by the Ti-doped SnO 2 support provide an alternative solution to reduce the cost of noble metal catalysts by improving the catalytic activity and stability.
    Note: Datenlieferant: KovsieScholar Repository (University of the Free State - UFS UV)
    Language: German
    DOI: 10.1021/acssuschemeng.2c06368.s001
    URL: https://doi.org/10.1021/acssuschemeng.2c06368.s001
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  • 6
    Online Resource
    Online Resource
    Phosphorylation Regulation Mechanism of β2 Integrin for the Binding of Filamin Revealed by Markov State Model (2023)
    Details
    UID:
    (DE-101)1288349106
    Format: Online-Ressource
    Content: Leukocyte adhesion deficiency-1 (LAD-1) disorder is a severe immunodeficiency syndrome caused by deficiency or mutation of β2 integrin. The phosphorylation on threonine 758 of β2 integrin acts as a molecular switch inhibiting the binding of filamin. However, the switch mechanism of site-specific phosphorylation at the atom level is still poorly understood. To resolve the regulation mechanism, all-atom molecular dynamics simulation and Markov state model were used to study the dynamic regulation pathway of phosphorylation. Wild type system possessed lower binding free energy and fewer number of states than the phosphorylated system. Both systems underwent local disorder-to-order conformation conversion when achieving steady states. To reach steady states, wild type adopted less number of transition paths/shortest path according to the transition path theory than the phosphorylated system. The underlying phosphorylated regulation pathway was from P1 to P0 and then P4 state, and the main driving force should be hydrogen bond and hydrophobic interaction disturbing the secondary structure of phosphorylated states. These studies will shed light on the pathogenesis of LAD-1 disease and lay a foundation for drug development.
    Note: Datenlieferant: KovsieScholar Repository (University of the Free State - UFS UV)
    Language: German
    DOI: 10.1021/acs.jcim.2c01177.s001
    URL: https://doi.org/10.1021/acs.jcim.2c01177.s001
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