UID:
edoccha_9959076722202883
Format:
1 online resource (224 p.)
ISBN:
1-283-15351-3
,
9786613153517
,
3-8055-9193-4
Series Statement:
Genome dynamics,
Content:
'Microbial Pathogenomics' contains a unique collection of reviews demonstrating how genomics has revolutionized our understanding of virulence, host-adaptation strategies and the evolution of bacterial pathogens. Current technologies - computational tools and functional approaches to genome analysis - are carefully documented and clearly illustrated. These include visualization tools for genome comparison, databases, in silico metabolic reconstructions and function prediction as well as interactomics for the study of protein-protein interactions. The concepts of pan-genomics and reverse vaccinology are introduced as strategies when addressing the challenge presented by bacterial diversity in the prevention and treatment of infectious diseases. The authors explore individual bacterial pathogens and discuss the mechanisms that have contributed to their evolutionary success. Special cases of host adaptation, for example, are illustrated by Helicobacter pylori and 'Mycobacterium tuberculosis' which are human-specific and highly persistent; further bacteria discussed include 'Escherichia coli, Campylobacter, Pseudomonas, Legionella, Bartonella, Burkholderia' and 'Staphylococcus'. 'Microbial Pathogenomics' provides the reader with a global view of key aspects and future trends in bacterial pathogenomics and evaluates their impact on the understanding and treatment of infectious diseases. Well illustrated and accessible to both specialists and nonspecialists, it is recommended not only for researchers in microbiology, genomics and biotechnology, but also for lecturers and teachers.
Note:
Description based upon print version of record.
,
""Cover""; ""Contents""; ""Editorial""; ""Preface""; ""Genome Comparison of Bacterial Pathogens""; ""Abstract""; ""Do Pathogens More Frequently Have Multiple DNA Replicons than Non-Pathogens?""; ""Do Pathogens Have a Genome Size or AT Content Different from Non-Pathogens?""; ""Can Local Variation in Base Content Identify DNA that is Horizontally Acquired?""; ""How Can DNA Base Composition Vary?""; ""How to Recognize DNA Insertions if Not by Base Composition?""; ""Phylogeny of Bacterial Genomes""; ""Know Your Sequenced Pathogen""; ""Concluding Remarks""; ""References""
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""In silico Reconstruction of the Metabolic and Pathogenic Potential of Bacterial Genomes Using Subsystems""""Abstract""; ""What is a Pathogen and what is a Virulence Factor?""; ""The First 1,000 Genomes""; ""Value Added by Curated Subsystems""; ""Comparative Pathogenomics Tools in NMPDR""; ""Conclusion""; ""Acknowledgements""; ""References""; ""The Bacterial Pan-Genome and Reverse Vaccinology""; ""Abstract""; ""Bacterial Diversity and the Pan-Genome Concept""; ""Reverse Vaccinology""; ""Data Integration""; ""Conclusion and Perspectives""; ""Acknowledgements""; ""References""
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""�Guilty by Association� � Protein-Protein Interactions (PPIs) in Bacterial Pathogens""""Abstract""; ""Protein-Protein Interaction Networks Govern Biological Processes in Living Cells""; ""PPI Assays Applied to Human Bacterial Pathogens""; ""What is the Impact of PPI Studies on Subsequent Research?""; ""Perspectives""; ""Acknowledgement""; ""References""; ""Helicobacter pylori Sequences Reflect Past Human Migrations""; ""Abstract""; ""Geographical Distribution of H. pylori Populations""; ""Recent Human Movements and Population Level Inconsistencies""
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""Prehistoric Human Migrations: The Sub-Population Level""""Looking further into a Complicated Past: Identifying Ancestral Populations""; ""Detecting Evolutionary Signal: H. pylori Out of Africa""; ""Other Microbes as Markers for Human Migrations""; ""Concluding Remarks""; ""References""; ""Helicobacter pylori Genome Plasticity""; ""Abstract""; ""The Genomic Landscape of H. pylori""; ""Mechanisms that Generate Genomic Variation in H. pylori""; ""Experimental Evidence for Adaptive Benefits of Mutation and Natural Transformation within H. pylori""
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""Host and Bacterial Population Structures that Promote Adaptive Changes""""Conclusion""; ""References""; ""Genomics of Thermophilic Campylobacter Species""; ""Abstract""; ""Campylobacter Biology""; ""An Overview of the Campylobacter Genome""; ""Comparative Genomic Analysis of Campylobacter""; ""Campylobacter Transcriptomics and Proteomics""; ""Development of Genetic Tools for Campylobacter""; ""Conclusions""; ""Acknowledgements""; ""References""; ""Adaptation of Pathogenic E. coli to Various Niches: Genome Flexibility is the Key""; ""Abstract""
,
""Genome Structure of Pathogenic and Non-Pathogenic E. coli""
,
English
Additional Edition:
ISBN 3-8055-9192-6
Language:
English
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