In:
Bioinformatics, Oxford University Press (OUP), Vol. 20, No. 10 ( 2004-07-01), p. 1482-1485
Kurzfassung:
Motivation: Substantial regional variations of substitutional processes have recently been reported from human/mouse comparisons. However, several features including the C + G dependence and the CpG-based transition effect remain obscure. Results: Utilizing the vast amount of transposable elements in the human genome, we performed detailed analysis of the substitutional and insertion/deletion patterns along the human lineage in a regional and time-resolved fashion. We observed a drastic increase in the CpG-based transition frequency at about the time of the mammalian radiation. We also observed clear regional biases of substitution patterns, most notably a bias to enrich the C+G content toward the telomeres. Availability: The programs used are available upon request from the authors.
Materialart:
Online-Ressource
ISSN:
1367-4811
,
1367-4803
DOI:
10.1093/bioinformatics/bth105
Sprache:
Englisch
Verlag:
Oxford University Press (OUP)
Publikationsdatum:
2004
ZDB Id:
1468345-3
SSG:
12
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