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  • 1
    Online Resource
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    Cardiac magnetic resonance T1 mapping. Part 1: Aspects of acquisition and evaluation
    Elsevier BV ; 2018
    In:  European Journal of Radiology Vol. 109 ( 2018-12), p. 223-234
    Details
    In: European Journal of Radiology, Elsevier BV, Vol. 109 ( 2018-12), p. 223-234
    Type of Medium: Online Resource
    ISSN: 0720-048X
    URL: Article
    DOI: 10.1016/j.ejrad.2018.10.011
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2005350-2
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  • 2
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    Cardiac magnetic resonance T1 mapping. Part 2: Diagnostic potential and applications
    Elsevier BV ; 2018
    In:  European Journal of Radiology Vol. 109 ( 2018-12), p. 235-247
    Details
    In: European Journal of Radiology, Elsevier BV, Vol. 109 ( 2018-12), p. 235-247
    Type of Medium: Online Resource
    ISSN: 0720-048X
    URL: Article
    DOI: 10.1016/j.ejrad.2018.10.013
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2005350-2
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  • 3
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    Differences in left ventricular and left atrial function assessed during breath-holding and breathing
    Elsevier BV ; 2021
    In:  European Journal of Radiology Vol. 141 ( 2021-08), p. 109756-
    Details
    In: European Journal of Radiology, Elsevier BV, Vol. 141 ( 2021-08), p. 109756-
    Type of Medium: Online Resource
    ISSN: 0720-048X
    URL: Article
    DOI: 10.1016/j.ejrad.2021.109756
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2005350-2
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  • 4
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    Automated vortical blood flow-based estimation of mean pulmonary arterial pressure from 4D flow MRI
    Elsevier BV ; 2022
    In:  Magnetic Resonance Imaging Vol. 88 ( 2022-05), p. 132-141
    Details
    In: Magnetic Resonance Imaging, Elsevier BV, Vol. 88 ( 2022-05), p. 132-141
    Type of Medium: Online Resource
    ISSN: 0730-725X
    URL: Article
    DOI: 10.1016/j.mri.2022.02.007
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 1500646-3
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  • 5
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    Left atrial acceleration factor as a magnetic resonance 4D flow measure of mean pulmonary artery wedge pressure in pulmonary hypertension
    Frontiers Media SA ; 2022
    In:  Frontiers in Cardiovascular Medicine Vol. 9 ( 2022-8-3)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-8-3)
    Abstract: Mean pulmonary artery wedge pressure (PAWP) represents a right heart catheter (RHC) surrogate measure for mean left atrial (LA) pressure and is crucial for the clinical classification of pulmonary hypertension (PH). Hypothesizing that PAWP is related to acceleration of blood throughout the LA, we investigated whether an adequately introduced LA acceleration factor derived from magnetic resonance (MR) four-dimensional (4D) flow imaging could provide an estimate of PAWP in patients with known or suspected PH. Methods LA 4D flow data of 62 patients with known or suspected PH who underwent RHC and near-term 1.5 T cardiac MR ( ClinicalTrials.gov identifier: NCT00575692) were retrospectively analyzed. Early diastolic LA peak outflow velocity ( v E ) as well as systolic ( v S ) and early diastolic ( v D ) LA peak inflow velocities were determined with prototype software to calculate the LA acceleration factor (α) defined as α = v E /[( v S + v D )/2]. Correlation, regression and Bland-Altman analysis were employed to investigate the relationship between α and PAWP, α-based diagnosis of elevated PAWP ( & gt;15 mmHg) was analyzed by receiver operating characteristic curve analysis. Results α correlated very strongly with PAWP ( r = 0.94). Standard deviation of differences between RHC-derived PAWP and PAWP estimated from linear regression model (α = 0.61 + 0.10·PAWP) was 2.0 mmHg. Employing the linear-regression-derived cut-off α = 2.10, the α-based diagnosis of elevated PAWP revealed the area under the curve 0.97 with sensitivity/specificity 93%/92%. Conclusions The very close relationship between the LA acceleration factor α and RHC-derived PAWP suggests α as potential non-invasive parameter for the estimation of PAWP and the distinction between pre- and post-capillary PH.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    DOI: 10.3389/fcvm.2022.972142
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2781496-8
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  • 6
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    Evaluation of left ventricular and left atrial volumetric function from native MR multislice 4D flow magnitude data
    Springer Science and Business Media LLC ; 2023
    In:  European Radiology
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    In: European Radiology, Springer Science and Business Media LLC
    Abstract: To assess the feasibility, precision, and accuracy of left ventricular (LV) and left atrial (LA) volumetric function evaluation from native magnetic resonance (MR) multislice 4D flow magnitude images. Materials & Methods In this prospective study, 60 subjects without signs or symptoms of heart failure underwent 3T native cardiac MR multislice 4D flow and bSSFP-cine realtime imaging. LV and LA volumetric function parameters were evaluated from 4D flow magnitude (4D flow-cine) and bSSFP-cine data using standard software to obtain end-diastolic volume (EDV), end-systolic volume (ESV), ejection-fraction (EF), stroke-volume (SV), LV muscle mass (LVM), LA maximum volume, LA minimum volume, and LA total ejection fraction (LATEF). Stroke volumes derived from both imaging methods were further compared to 4D pulmonary artery flow-derived net forward volumes (NFV). Methods were compared by correlation and Bland-Altman analysis. Results Volumetric function parameters from 4D flow-cine and bSSFP-cine showed high to very high correlations (r = 0.83-0.98). SV, LA volumes and LATEF did not differ between methods. LV end-diastolic and end-systolic volumes were slightly underestimated (EDV: –2.9 ± 5.8 mL; ESV: -2.3 ± 3.8 mL), EF was slightly overestimated (EF: 0.9 ± 2.6%), and LV mass was considerably overestimated (LVM: 39.0 ± 11.4 g) by 4D flow-cine imaging. SVs from both methods correlated very highly with NFV (r = 0.91 in both cases) and did not differ from NFV. Conclusion Native multislice 4D flow magnitude data allows precise evaluation of LV and LA volumetric parameters; however, apart from SV, LV volumetric parameters demonstrate bias and need to be referred to their respective normal values. Clinical relevance statement Volumetric function assessment from native multislice 4D flow magnitude images can be performed with routinely used clinical software, facilitating the application of 4D flow as a one-stop-shop functional cardiac MR exam, providing consistent, simultaneously acquired, volume and flow data. Key points • Native multislice 4D flow imaging allows evaluation of volumetric left ventricular and atrial function parameters. • Left ventricular and left atrial function parameters derived from native multislice 4D flow data correlate highly with corresponding standard cine-derived parameters. • Multislice 4D flow-derived volumetric stroke volume and net forward volume do not differ.
    Type of Medium: Online Resource
    ISSN: 1432-1084
    URL: Article
    DOI: 10.1007/s00330-023-10017-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1472718-3
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  • 7
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    Quantitative Clinical Cardiac Magnetic Resonance Imaging
    Georg Thieme Verlag KG ; 2020
    In:  RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren Vol. 192, No. 03 ( 2020-03), p. 246-256
    Details
    In: RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, Georg Thieme Verlag KG, Vol. 192, No. 03 ( 2020-03), p. 246-256
    Abstract: Hintergrund Die kardiale Magnetresonanztomografie (MRT) stellt sowohl in der Beurteilung der Herzfunktion als auch zur nichtinvasiven Gewebsanalyse des Myokards in vielen klinischen Fragestellungen die Referenz-Standard-Methode dar. Speziell die Quantifizierung kardialer Parameter nimmt eine immer zentralere diagnostische und differenzialdiagnostische Rolle ein. Im vorliegenden Review sollen etablierte und vielversprechende neue quantitative Herz-MRT-Parameter der klinischen Routine zusammengefasst, ihre Zusammenhänge beschrieben sowie ihre Abhängigkeiten von substanziellen Einflussfaktoren dargestellt werden. Methode Die Übersichtsarbeit basiert auf einer PubMed-Literaturrecherche zu den Begriffen „cardiac magnetic resonance“ und „quantification“, „recommendations“, „quantitative evaluation/assessment“, „reference method“, „reference/normal values“, „pitfalls“ sowie „artifacts“ innerhalb des Publikationszeitraums 2000–2019. Ergebnisse und Schlussfolgerung Funktionelle, Phasenkontrast- und Perfusionsbildgebung sowie Relaxationszeit-Kartierung ermöglichen die Erfassung einer Vielzahl quantitativer Herz-MRT-Parameter. Diese erlauben eine über die visuelle Beurteilung von Herz-MRT-Bildern hinausgehende Charakterisierung der Funktion, Morphologie und Perfusion des Herzens, sei es im Vergleich zu Normalwerten oder im Therapieverlauf. Bei der Interpretation ausgewerteter Herz-MRT-Parameter in der klinischen Routine muss allerdings zunehmend auf Standardisierung geachtet werden, da Aufnahmetechniken und Auswertealgorithmen quantitative Ergebnisse maßgeblich – jedoch mitunter nicht unmittelbar erkennbar – beeinflussen können. Kernaussagen:  Zitierweise
    Type of Medium: Online Resource
    ISSN: 1438-9029 , 1438-9010
    URL: Article
    DOI: 10.1055/a-0999-5716
    RVK:
    XA 10000
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2020
    detail.hit.zdb_id: 2031079-1
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  • 8
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    Impact of the Choice of Native T 1 in Pixelwise Myocardial Blood Flow Quantification
    Wiley ; 2021
    In:  Journal of Magnetic Resonance Imaging Vol. 53, No. 3 ( 2021-03), p. 755-765
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 53, No. 3 ( 2021-03), p. 755-765
    Abstract: Quantification of myocardial blood flow (MBF) from dynamic contrast‐enhanced (DCE) MRI can be performed using a signal intensity model that incorporates T 1 values of blood and myocardium. Purpose To assess the impact of T 1 values on pixelwise MBF quantification, specifically to evaluate the influence of 1) study population‐averaged vs. subject‐specific, 2) diastolic vs. systolic, and 3) regional vs. global myocardial T 1 values. Study Type Prospective. Subjects Fifteen patients with chronic coronary heart disease. Field Strength/Sequence 3T; modified Look–Locker inversion recovery for T 1 mapping and saturation recovery gradient echo for DCE imaging, both acquired in a mid‐ventricular short‐axis slice in systole and diastole. Assessment MBF was estimated using Fermi modeling and signal intensity nonlinearity correction with different T 1 values: study population‐averaged blood and myocardial, subject‐specific systolic and diastolic, and segmental T 1 values. Myocardial segments with perfusion deficits were identified visually from DCE series. Statistical Tests The relationships between MBF parameters derived by different methods were analyzed by Bland–Altman analysis; corresponding mean values were compared by t ‐test. Results Using subject‐specific diastolic T 1 values, global diastolic MBF was 0.61 ± 0.13 mL/(min·g). It did not differ from global MBF derived from the study population‐averaged T 1 ( P = 0.88), but the standard deviation of differences was large (0.07 mL/(min·g), 11% of mean MBF). Global diastolic and systolic MBF did not differ ( P = 0.12), whereas global diastolic MBF using systolic (0.62 ± 0.13 mL/(min·g)) and diastolic T 1 values differed ( P   〈  0.05). If regional instead of global T 1 values were used, segmental MBF was lower in segments with perfusion deficits (bias = −0.03 mL/(min·g), −7% of mean MBF, P   〈  0.05) but higher in segments without perfusion deficits (bias = 0.01 mL/(min·g), 1% of mean MBF, P   〈  0.05). Data Conclusion Whereas cardiac phase‐specific T 1 values have a minor impact on MBF estimates, subject‐specific and myocardial segment‐specific T 1 values substantially affect MBF quantification. Level of Evidence 3 Technical Efficacy Stage 3
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v53.3
    DOI: 10.1002/jmri.27375
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1497154-9
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  • 9
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    Automated mitral valve vortex ring extraction from 4D‐flow MRI
    Wiley ; 2020
    In:  Magnetic Resonance in Medicine Vol. 84, No. 6 ( 2020-12), p. 3396-3408
    Details
    In: Magnetic Resonance in Medicine, Wiley, Vol. 84, No. 6 ( 2020-12), p. 3396-3408
    Abstract: To present and validate a method for automated extraction and analysis of the temporal evolution of the mitral valve (MV) vortex ring from MR 4D‐flow data. Methods The proposed algorithm uses the divergence‐free part of the velocity vector field for Q criterion‐based identification and tracking of MV vortex ring core and region within the left ventricle (LV). The 4D‐flow data of 20 subjects (10 healthy controls, 10 patients with ischemic heart disease) were used to validate the algorithm against visual analysis as well as to assess the method’s sensitivity to manual LV segmentation. Quantitative MV vortex ring parameters were analyzed with respect to both their differences between healthy subjects and patients and their correlation with transmitral peak velocities. Results The algorithm successfully extracted MV vortex rings throughout the entire cardiac cycle, which agreed substantially with visual analysis (Cohen’s kappa = 0.77). Furthermore, vortex cores and regions were robustly detected even if a static end‐diastolic LV segmentation mask was applied to all frames (Dice coefficients 0.82 ± 0.08 and 0.94 ± 0.02 for core and region, respectively). Early diastolic MV vortex ring vorticity, kinetic energy and circularity index differed significantly between healthy controls and patients. In contrast to vortex shape parameters, vorticity and kinetic energy correlated strongly with transmitral peak velocities. Conclusion An automated method for temporal MV vortex ring extraction demonstrating robustness with respect to LV segmentation strategies is introduced. Quantitative vortex parameter analysis indicates importance of the MV vortex ring for LV diastolic (dys)function.
    Type of Medium: Online Resource
    ISSN: 0740-3194 , 1522-2594
    URL: Issue
    URL: Article
    DOI: 10.1002/mrm.v84.6
    DOI: 10.1002/mrm.28361
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1493786-4
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  • 10
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    MR 4D flow-based mean pulmonary arterial pressure tracking in pulmonary hypertension
    Springer Science and Business Media LLC ; 2021
    In:  European Radiology Vol. 31, No. 4 ( 2021-04), p. 1883-1893
    Details
    In: European Radiology, Springer Science and Business Media LLC, Vol. 31, No. 4 ( 2021-04), p. 1883-1893
    Abstract: Longitudinal hemodynamic follow-up is important in the management of pulmonary hypertension (PH). This study aimed to evaluate the potential of MR 4-dimensional (4D) flow imaging to predict changes in the mean pulmonary arterial pressure (mPAP) during serial investigations. Methods Forty-four adult patients with PH or at risk of developing PH repeatedly underwent routine right heart catheterization (RHC) and near-term MR 4D flow imaging of the main pulmonary artery. The duration of vortical blood flow along the main pulmonary artery was evaluated from MR 4D velocity fields using prototype software and converted to an MR 4D flow imaging-based mPAP estimate (mPAP MR ) by a previously established model. The relationship of differences between RHC-derived baseline and follow-up mPAP values (ΔmPAP) to corresponding differences in mPAP MR (ΔmPAP MR ) was analyzed by means of regression and Bland-Altman analysis; the diagnostic performance of ΔmPAP MR in predicting mPAP increases or decreases was investigated by ROC analysis. Results Areas under the curve for the prediction of mPAP increases and decreases were 0.92 and 0.93, respectively. With the natural cutoff ΔmPAP MR = 0 mmHg, mPAP increases (decreases) were predicted with an accuracy, sensitivity, and specificity of 91% (91%), 85% (89%), and 94% (92%), respectively. For patients in whom 4D flow allowed a point estimate of mPAP (mPAP 〉 16 mmHg), ΔmPAP MR correlated strongly with ΔmPAP ( r = 0.91) and estimated ΔmPAP bias-free with a standard deviation of 5.1 mmHg. Conclusions MR 4D flow imaging allows accurate non-invasive prediction and quantification of mPAP changes in adult patients with PH or at risk of developing PH. Trial registration ClinicalTrials.gov identifier: NCT00575692 and NCT01725763 Key Points • MR 4D flow imaging allows accurate non-invasive prediction of mean pulmonary arterial pressure increases and decreases in adult patients with or at risk of developing pulmonary hypertension. • In adult patients with mean pulmonary arterial pressure 〉 16 mmHg, MR 4D flow imaging allows estimation of longitudinal mean pulmonary arterial pressure changes without bias with a standard deviation of 5.1 mmHg.
    Type of Medium: Online Resource
    ISSN: 0938-7994 , 1432-1084
    URL: Article
    DOI: 10.1007/s00330-020-07287-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 1472718-3
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