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Background: The role of fatty acid (FA) intake and metabolism in type 2 diabetes (T2D) incidence is controversial. Some FAs are not synthesised endogenously and, therefore, these circulating FAs reflect dietary intake, for example, the trans fatty acids (TFAs), saturated odd chain fatty acids (OCFAs), and linoleic acid, an n-6 polyunsaturated fatty acids (PUFA). It remains unclear if intake of TFA influence T2D risk and whether industrial TFAs (iTFAs) and ruminant TFAs (rTFAs) exert the same effect. Unlike even chain saturated FAs, the OCFAs have been inversely associated with T2D risk, but this association is poorly understood. Furthermore, the associations of n-6 PUFAs intake with T2D risk are still debated, while delta-5 desaturase (D5D), a key enzyme in the metabolism of PUFAs, has been consistently related to T2D risk. To better understand these relationships, the FA composition in circulating lipid fractions can be used as biomarkers of dietary intake and metabolism. The exploration of TFAs subtypes in plasma phospholipids and ...
Anmerkung:
kumulative Dissertation
,
Dissertation Universität Potsdam 2023
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe Prada Acuña, Marcela Fatty acid biomarkers of intake and metabolism and their association with type 2 diabetes Potsdam, 2022
Sprache:
Englisch
Schlagwort(e):
Hochschulschrift
DOI:
10.25932/publishup-58159
URN:
urn:nbn:de:kobv:517-opus4-581598
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