UID:
edoccha_9959076710702883
Format:
1 online resource (247 p.)
ISBN:
3-318-02270-5
Series Statement:
Nestlé Nutrition Institute workshop series, volume 71
Content:
Growth in mammals encompasses several stages, from intrauterine growth through infancy and childhood to adolescence. Each of these phases is characterized by very specific nutritional, molecular and endocrine perspectives which, under ideal conditions, allow the organism to achieve its genetically programmed growth patterns. In this book, an international panel of experts addresses these topics in a historical, physiological and social perspective. The first part investigates the genetic, epigenetic, molecular and nutritional determinants of intrauterine and postnatal growth. Part two deals with non-evolutionary changes which occurred in the recent past, such as changes in body size in utero, during infancy and childhood, and during adolescence, and the potentially unfavorable consequences of enhanced nutrition and growth, including early onset of puberty, development of obesity, and increases in metabolic and cardiovascular disease. The last part addresses the question of which factors define healthy growth in light of the influence of nutritional, molecular and endocrine influences. Although the association between rapid changes in body size and adverse health effects is clear, the precise nature of causality remains uncertain. Presenting the latest scientific findings in growth research, this publication provides essential reading for pediatricians, clinical investigators and health workers.
Note:
Description based upon print version of record.
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""Cover""; ""Front Matter""; ""Contents""; ""Preface""; ""Foreword""; ""Contributors""; ""Drivers of Growth""; ""Early Influences of Nutrition on FetalGrowth""; ""Abstract""; ""Macronutrient Interventions That Have Varied Energy""; ""Nutrient Interventions That Do Not Vary Energy""; ""Conclusions""; ""References""; ""Early Influences of Nutritionon Postnatal Growth""; ""Abstract""; ""Postnatal Diet, Growth Patterns, and the Later Risk of Obesity and Related Non-Communicable Diseases""; ""Protective Effects of Breastfeeding on Obesity Risk in Later Life""
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""Mechanisms of Protective Effects of Breastfeeding: The �Early Protein Hypothesis�""""Biochemical and Endocrine Markers""; ""Conclusions""; ""Appendix""; ""Acknowledgements""; ""References""; ""Genome-Wide Association Studies of Human Growth Traits""; ""Abstract""; ""Introduction""; ""The First Successes for GWA Studies of Growth Traits � FTO and HMGA2""; ""Increasing Sample Size by Collaboration and Meta-Analysis Identifies Hundreds of Loci for Adult Height and Other Anthropometric Traits""; ""GWA Studies of Early Growth""; ""GWA Studies of Pubertal Growth""
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""The Genetics of Growth Is More Complex Than Previously Appreciated""""What GWA Studies Have Not Told Us � The Missing Heritability""; ""Conclusions""; ""References""; ""Discussion on Nutrition and Genetics""; ""Nutrition""; ""Genetics""; ""IGF- I in Human Growth: Lessons from Defects in the GH-IGF-I Axis""; ""Abstract""; ""Normal Human Growth Is Dependent on IGF-I""; ""The Human GH-IGF-I Axis in Human Growth""; ""Defects in the GH-IGF Axis: What Gene Analyses Reveal""; ""Conclusions""; ""References""; ""Non-Imprinted Epigenetics in Fetal and Postnatal Development and Growth""
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""Abstract""""References""; ""Epigenetic Anomalies in Childhood Growth Disorders""; ""Abstract""; ""Introduction""; ""Russell-Silver Syndrome""; ""Beckwith-Wiedemann Syndrome""; ""Human Multilocus Imprinting Disorders""; ""Assisted Reproductive Technologies and Loss of Imprinting""; ""Conclusion""; ""References""; ""Early Growth and Development of Later Life Metabolic Disorders""; ""Abstract""; ""Introduction""; ""Physiology of Growth""; ""Epidemiological Evidence of Early-Life Developmental Programming""; ""Genetic Factors Modulating Growth and Metabolic Disorder""
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""Epigenetic Programming""""Other Postulated Mechanisms""; ""Leptin and the GH-IGF Axis""; ""Uncertainties""; ""References""; ""Summary on Drivers of Growth""; ""Secular Trends in Growth""; ""Human Growth: Evolutionary and Life History Perspectives""; ""Abstract""; ""Some General Evolutionary Principles""; ""The Role of Developmental Plasticity""; ""Life History Theory""; ""Heritability, Genetics, Non-Genetic Inheritance and Phenotypic-Driven Evolution""; ""An Evolutionary and Life History Perspective on Human Growth""; ""Puberty""; ""Adolescence""; ""Final Remarks""; ""Appendix""
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""Acknowledgements""
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English
Additional Edition:
ISBN 3-318-02269-1
Language:
English
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