Format:
Online-Ressource (VIII, 446 p. 22 illus., 21 illus. in color, digital)
ISBN:
9781461461760
,
1283945894
,
9781283945899
Series Statement:
Advances in Experimental Medicine and Biology 779
Content:
The topic of ‘Impact of genetic targets on cancer therapy’ has reviews that each focuses on a specific tumor type, review recent knowledge about molecular pathogenesis in general and especially as it impacts response to therapy. The topic is aimed to provide a forum for publication of original peer-reviewed short communications, full-length research and review articles on new research findings and developments in cancer therapies. As the field is highly important it requires co-operation between research communities from all over the world to share their knowledge and experience in order to build a comprehensive knowledge on genetic targets on different cancer therapies. Each chapter also includes a discussion of the impact of the tumor microenvironment and cancer stem cells and cover current knowledge in this area as it pertains to the disease, including emerging therapy targeting the microenvironment and/or cancer stem cells
Note:
Description based upon print version of record
,
Impact of Genetic Targetson Cancer Therapy; Forward; Contents; Novel Antineoplastics Targeting Genetic Changes in Colorectal Cancer; Introduction; Overview of Genetic Alterations in Colorectal Cancer; Targeting Cell Death Pathways; Agonistic TRAIL Death Receptor Antibodies; Bcl-2; Targeting Growth Factor Signaling; The EGFR Family; IGF Receptors; Hepatocyte Growth Factor (HGF); Mutant BRAF; MEK; Akt; Mammalian Target of Rapamycin (mTOR); Protein Kinase C (PKC); Targeting Angiogenesis; VEGF Receptors; Other Receptors That Mediate Angiogenesis; Multi-Targeted Agents; Sorafenib; Sunitinib
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DasatinibHarnessing the Immune System; Epithelial Cell Adhesion Molecule (EpCAM); Toll-Like Receptor 9 (TLR9); A33; Other Approaches; Wnt and Hedgehog Signaling Pathways; COX-2; Heat Shock Protein 90 (Hsp90); Virotherapy; Colorectal Cancer Stem Cells (CRCSCs); Stem Cell Signaling in CRC; Stem Cell Microenvironment in CRC; References; Update on Clinical Trials: Genetic Targets in Breast Cancer; Cell Membrane Signaling; Growth Factor Receptors EGFR and HER2- neu as Molecular Targets in Breast Cancer; IGF in Breast Cancer; Impact of the Tumor Microenvironment and Cancer Stem Cells
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Cancer Stem Cells and Stem Cell Niche in Breast CancerAngiogenic Targets; Intracellular Signaling and Genetic, Epigenetic Targets; Intracellular Signaling; Ras, Raf, mTOR; Post-Translational Modi fi cation: Histone Deacytelase Inhibitors (HDACIs); MicroRNAs and the Molecular Pathogenesis of Breast Cancer; Telomerase Inhibitors in Breast Cancer; PARP in Breast Cancer; Hormone Receptor Positive but Resistant to Hormone Therapy; Mechanisms of Hormone Resistance; Conclusion; References; Impact of Genetic Targets on Cancer Therapy in Esophagogastric Cancer; Introduction
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Targeting Epidermal Growth Factor Receptor (EGFR) Family PathwayTargeting Angiogenesis Pathway; Other Potential Targets; Conclusions; References; Impact of Genetic Targets on Cancer Therapy: Hepatocellular Cancer; Introduction; Pathogenesis and Genetics for HCC; Hepatitis Virus Infections and HCC; Sorafenib and Targeted Therapy for HCC; Types of Targeted Therapies; Tyrosine Kinase Inhibitors TKIs; Monoclonal Antibodies (mABs); Enzyme Inhibitors; Miscellaneous Agents; Combination Therapy and Future Directions; Cancer Stem Cells and New Targets in HCC; Conclusion; References
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Toward the Goal of Personalized Therapy in Pancreatic Cancer by Targeting the Molecular PhenotypeIntroduction; Genetic Alterations Involved in Pathogenesis of Pancreatic Adenocarcinoma; Genetic Alterations as Therapeutic Targets; Receptor Tyrosine Kinases and Ligands; Epidermal Growth Factor (EGF); Insulin-Like Growth Factor-1 (IGF-1); Hepatocyte Growth Factor (HGF); Signal Transducers; RAS; MEK; AKT; Mammalian Target of Rapamycin (mTOR); Heat Shock Protein (Hsp90); Nuclear Targets; Histone Deacetylases (HDACs); Polo-Like Kinase 1 (Plk1); Ribonucleotide Reductase (RR)
,
Peroxisome Proliferator-Activated Receptor g (PPAR g)
,
Novel antineoplastics targeting genetic changes in colorectal cancer -- Update on Clinical Trials: Genetic Targets in Breast Cancer -- Impact of Genetic Targets on Cancer Therapy in Esophagogastric Cancer -- Impact of Genetic Targets on Cancer Therapy: Liver Cancer -- Targeting the molecular phenotype of pancreatic cancer toward the goal of patient-tailored therapy -- Impact of genetic markers on treatment of Non-small cell lung cancer -- Impact of Genetic Targets on Therapy in Head and Neck Squamous Cell Carcinoma -- Tyrosine Kinase Targeted Treatment of Chronic Myelogenous Leukemia and Other Myeloproliferative Neoplasms -- Targeted Therapy of Multiple Myeloma -- Current and Future Trials of Targeted Therapies in Cutaneous Melanoma -- Current Approaches to Epigenetic therapy for the treatment of Mantle Cell Lymphoma -- Impact of Genetic Targets on Primary Brain Tumor Therapy: What’s Ready for Prime Time? -- Rational therapy for renal cell carcinoma based on its genetic targets -- Molecular and Genetic Markers of Follicular-Cell Thyroid Cancer: Etiology and Diagnostic and Therapeutic Opportunities -- Genetic Targets in Pediatric Acute Lymphoblastic Leukemia -- Emerging molecular therapies for the treatment of Acute Lymphoblastic Leukemia -- Impact of Genetic Targets on Prostate Cancer Therapy -- Small-Cell Lung Cancer: An Update on Targeted Therapies -- Impact of Genetic Targets on Cancer Therapy in Acute Myelogenous Leukemia -- Index.
Additional Edition:
ISBN 9781461461753
Additional Edition:
Buchausg. u.d.T. ISBN 978-1-461-46175-3
Language:
English
DOI:
10.1007/978-1-4614-6176-0
URL:
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