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  • Cambridge University Press (CUP)  (2,133)
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  • Cambridge University Press (CUP)  (2,133)
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  • 1
    Online Resource
    Online Resource
    Case Report Klinefelter Syndrome and Multiple Sclerosis as the Cause of Psychosis
    Cambridge University Press (CUP) ; 2017
    In:  European Psychiatry Vol. 41, No. S1 ( 2017-04), p. S638-S638
    Details
    In: European Psychiatry, Cambridge University Press (CUP), Vol. 41, No. S1 ( 2017-04), p. S638-S638
    Abstract: Forty-three-year-old male diagnosed with Klinefelter syndrome and showing radiological findings suggesting a demyelinating pathology who presents several psychiatric manifestations including megalomaniacal ideation, delusion, lack of impulse control and behavioral alterations. Clinical case Forty-three-year-old male diagnosed with Klinefelter syndrome at the age of 31, presenting several psychiatric pathologies since adolescence: delusions, megalomania, mood fluctuation, and high impulsiveness. The patient had a poor therapeutic response to anti-psychotic drugs and ECT. He was hospitalized up to 9 times, but the full control of the symptomatology was not achieved. During his last hospitalization, a MRI revealed lesions compatible with a demyelinating pathology. Discussion A higher prevalence of schizophrenia spectrum disorders has been described among patients suffering from Klinefelter syndrome, which might explain the role of the X chromosome in the susceptibility to psychiatric disorders, particularly to psychosis. Furthermore, the brain structure alterations presented by patients suffering from Klinefelter syndrome are similar to those described among schizophrenic patients: small brain volume, lateral cerebral ventricular enlargement and reduced temporal gyrus, amygdala, insula and cingulate cortex. Patients suffering from multiple sclerosis are more prone to psychiatric disorders, such as mood swing, aggressiveness or psychosis, which are not concurrent with the physical progression of the disease, sometimes being its first manifestation. Even when being patchy and multifocal, demyelination seems to be concentrated in the frontal lobes, related to the cognitive and affective functions and the personality. Conclusions Both multiple sclerosis and Klinefelder syndrome may alter the brain structure, mainly in the frontal lobe, and predispose to psychiatric disorders. Disclosure of interest The authors have not supplied their declaration of competing interest.
    Type of Medium: Online Resource
    ISSN: 0924-9338 , 1778-3585
    URL: Article
    DOI: 10.1016/j.eurpsy.2017.01.1049
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2017
    detail.hit.zdb_id: 2005377-0
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  • 2
    Online Resource
    Online Resource
    A comparison of the degree of implementation of marine biodiversity indicators by European countries in relation to the Marine Strategy Framework Directive (MSFD)
    Cambridge University Press (CUP) ; 2015
    In:  Journal of the Marine Biological Association of the United Kingdom Vol. 95, No. 8 ( 2015-12), p. 1519-1531
    Details
    In: Journal of the Marine Biological Association of the United Kingdom, Cambridge University Press (CUP), Vol. 95, No. 8 ( 2015-12), p. 1519-1531
    Abstract: The degree of development and operability of the indicators for the Marine Strategy Framework Directive (MSFD) using Descriptor 1 (D1) Biological Diversity was assessed. To this end, an overview of the relevance and degree of operability of the underlying parameters across 20 European countries was compiled by analysing national directives, legislation, regulations, and publicly available reports. Marked differences were found between countries in the degree of ecological relevance as well as in the degree of implementation and operability of the parameters chosen to indicate biological diversity. The best scoring EU countries were France, Germany, Greece and Spain, while the worst scoring countries were Italy and Slovenia. No country achieved maximum scores for the implementation of MSFD D1. The non-EU countries Norway and Turkey score as highly as the top-scoring EU countries. On the positive side, the chosen parameters for D1 indicators were generally identified as being an ecologically relevant reflection of Biological Diversity. On the negative side however, less than half of the chosen parameters are currently operational. It appears that at a pan-European level, no consistent and harmonized approach currently exists for the description and assessment of marine biological diversity. The implementation of the MSFD Descriptor 1 for Europe as a whole can therefore at best be marked as moderately successful.
    Type of Medium: Online Resource
    ISSN: 0025-3154 , 1469-7769
    URL: Article
    DOI: 10.1017/S0025315415000235
    RVK:
    WA 15000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2015
    detail.hit.zdb_id: 1491269-7
    detail.hit.zdb_id: 281325-7
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Relationship between drug dreams, affect, mood disorders and lucid awakening in psychotic patients on a treatment
    Cambridge University Press (CUP) ; 2016
    In:  European Psychiatry Vol. 33, No. S1 ( 2016-03), p. S411-S411
    Details
    In: European Psychiatry, Cambridge University Press (CUP), Vol. 33, No. S1 ( 2016-03), p. S411-S411
    Abstract: This experimental trial aims to describe the experiences felt by a group of patients diagnosed with different psychotic disorders (schizophrenia, delusional chronic disorder, etc.) in which the use of Benzodiazepine derivatives were related to emergence of lucid dreaming and dissociative events (to see oneself out of your one body, etc.), and to a lesser extent had subsequent depressive symptoms. Fifty-six patients were monitored and linked to the emergence of depressive symptoms related to the use of Benzodiazepines or sedative-hypnotic. While on this treatment, they had vivid or lucid dreaming. Aims-objectives To explore the relationship between occurrence of drug dreams (DDs) and daytime negative affect with lucid awakening during the course of a 9-week treatment. Methods Using the dream journal methodology, 56 participants reported occurrence of dreams, dream content, and ratings of affect. The relationships between the experience of DD, dream content (“active” vs “passive”), and affect were analysed using mixed model methods. Results The experience of DD was associated with higher levels of negative affect ( P 〈 0.001). The occurrence of DD did not decrease significantly over the 9 weeks of the study. Benzodiazepine users reported a higher occurrence of Lucid Awakening ( P 〈 0.05) than the other drug groups (zolpidem and clometiazol). Conclusions These results are consistent with the hypothesis that DD can act as drug-conditioned stimuli to elevate negative affect. Although correlational, such findings support the implementation of psychological and pharmacological interventions aimed at minimizing the impact of DD on patients with lucid awakening and psychosis. Disclosure of interest The authors have not supplied their declaration of competing interest.
    Type of Medium: Online Resource
    ISSN: 0924-9338 , 1778-3585
    URL: Article
    DOI: 10.1016/j.eurpsy.2016.01.1484
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2016
    detail.hit.zdb_id: 2005377-0
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  • 4
    Online Resource
    Online Resource
    Use of interferon-α in laryngeal papillomatosis: eight years of the Cuban national programme
    Cambridge University Press (CUP) ; 1997
    In:  The Journal of Laryngology & Otology Vol. 111, No. 2 ( 1997-02), p. 134-140
    Details
    In: The Journal of Laryngology & Otology, Cambridge University Press (CUP), Vol. 111, No. 2 ( 1997-02), p. 134-140
    Abstract: Laryngeal papillomatosis is one of the first diseases where interferon (IFN) was found to be effective. In 1983, a programme for the treatment of all such cases started in Cuba. Up to December 1991, 125 patients (92 children, 33 adults) have been treated: 102 with leucocyte IFN-α, 12 with recombinant IFN-α-2b, and 11 have received both preparations. Case management consisted of surgical removal of the lesions followed by an IFN schedule starting with 10 5 IU/kg of weight in children or 6 × 10 6 IU in adults, i.m. daily. The dose was progressively reduced, as long as no relapses occurred. At the end of the one-year schedule the doses were reduced to 5 × 10 4 IU/kg in children or 3 × 10 6 IU in adults, weekly. If there was a relapse, it was removed surgically and the patient returned to a higher dose level. Most cases (89; 71 per cent) have not relapsed after the treatment; 60 of them have been followed for more than three years. In those with relapses, the frequency of recurrence decreased in all but four patients. The treatment seemed to be more effective if initiated less than three months after the disease onset. The tracheostomy could be removed in five out of seven patients who needed it before the IFN treatment and was necessary in only three new cases during IFN treatment. In two of these, decannulation was possible later on. In a total of 14 patients relapses persisted after several cycles of IFN treatment. They were considered resistant to such treatment. No severe side effects were reported. The most frequent ones were fever, drowsiness, increased bronchial secretion, chills and headache. The establishment of this programme has maintained the disease under control in Cuba.
    Type of Medium: Online Resource
    ISSN: 0022-2151 , 1748-5460
    URL: Article
    DOI: 10.1017/S0022215100136667
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1997
    detail.hit.zdb_id: 2013209-8
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  • 5
    Online Resource
    Online Resource
    Distribution of English textiles in the Spanish market at the beginning of the 18 th century
    Cambridge University Press (CUP) ; 2013
    In:  Revista de Historia Económica / Journal of Iberian and Latin American Economic History Vol. 31, No. 2 ( 2013-09), p. 253-284
    Details
    In: Revista de Historia Económica / Journal of Iberian and Latin American Economic History, Cambridge University Press (CUP), Vol. 31, No. 2 ( 2013-09), p. 253-284
    Abstract: En este trabajo se analiza la comercialización y distribución de tejidos extranjeros en la sub-meseta norte de España a comienzos del setecientos a través de una fuente fiscal que nos permite matizar ciertos aspectos relacionados con la demanda de textiles. La fuente utilizada en este trabajo es un impuesto que se cobraba sobre los textiles importados en tiempos de guerra y que recoge quien enviaba la mercancía, el receptor de la misma, el transportista, el tipo de tejido, su valor fiscal, la cantidad así como el impuesto extraordinario pagado que iba a la tesorería real. Los resultados de este estudio permiten analizar en profundidad por lo tanto las redes de distribución y el tipo de tejidos ingleses que se demandaban.
    Type of Medium: Online Resource
    ISSN: 0212-6109 , 2041-3335
    URL: Article
    DOI: 10.1017/S0212610913000116
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2013
    detail.hit.zdb_id: 2485162-0
    SSG: 7,34
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  • 6
    Online Resource
    Online Resource
    Development and characterization of monoclonal antibodies against Besnoitia besnoiti tachyzoites
    Cambridge University Press (CUP) ; 2019
    In:  Parasitology Vol. 146, No. 2 ( 2019-02), p. 187-196
    Details
    In: Parasitology, Cambridge University Press (CUP), Vol. 146, No. 2 ( 2019-02), p. 187-196
    Abstract: This is the first report on the development and characterization of eight monoclonal antibodies (MABs) generated against whole- and membrane-enriched tachyzoite extracts of the apicomplexan parasite Besnoitia besnoiti . Confocal laser scanning immunofluorescence microscopy was used to localize respective epitopes in B. besnoiti tachyzoites along the lytic cycle. A pattern compatible with dense granule staining was observed with MABs 2.A.12, 2.F.3 and 2.G.4, which could be confirmed by immunogold electron microscopy for MABs 2.A.12 and 2.F.3. In particular, MABs 2.F.3 and 2.G.4 were secreted during early invasion, proliferation and egress phases. MABs 3.10.8 and 5.5.11 labelled the tachyzoite surface, whilst MABs 1.17.8, 8.9.2 and 2.G.A recognized the apical tip, which is reminiscent for microneme localization. Besides, the epitopes recognized by the latter two (MABs 8.9.2 and 2.G.A) exhibited a redistribution from the anterior part across the parasite surface towards the posterior end during invasion. Most MABs developed were genus-specific. Indeed, the MABs cross-reacted neither with T. gondii nor with N. caninum tachyzoites. In summary, we have generated MABs that will be useful to study the key processes in the lytic cycle of the parasite and with additional promising diagnostic value. However, the molecular identity of the antigens recognized remains to be elucidated.
    Type of Medium: Online Resource
    ISSN: 0031-1820 , 1469-8161
    URL: Article
    DOI: 10.1017/S0031182018001336
    RVK:
    WA 15000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2019
    detail.hit.zdb_id: 1491287-9
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Physical activity in anorexia nervosa: How relevant is it to therapy response?
    Cambridge University Press (CUP) ; 2015
    In:  European Psychiatry Vol. 30, No. 8 ( 2015-11), p. 924-931
    Details
    In: European Psychiatry, Cambridge University Press (CUP), Vol. 30, No. 8 ( 2015-11), p. 924-931
    Abstract: Elevated physical activity has been observed in some patients with anorexia nervosa (AN) despite their emaciated condition. However, its effects on treatment outcome remain unclear. This study aimed to examine objectively measured physical activity in this clinical population and how it might be related to a partial hospitalization therapy response, after considering potential confounders. Method The sample comprised 88 AN patients consecutively enrolled in a day hospital treatment program, and 116 healthy-weight controls. All participants were female and a baseline assessment took place using an accelerometer (Actiwatch AW7) to measure physical activity, the Eating Disorders Inventory-2 and the Depression subscale of the Symptom Checklist-Revised. Outcome was evaluated upon the termination of the treatment program by expert clinicians. Results Although AN patients and controls did not differ in the average time spent in moderate-to-vigorous physical activity (MVPA) ( P = .21), nor daytime physical activity ( P = .34), fewer AN patients presented a high physical activity profile compared to the controls (37% vs. 61%, respectively; P = .014). Both lower levels of MVPA and greater eating disorder severity had a direct effect on a poor treatment outcome. Depression symptoms in the patients were associated with lower MVPA, as well as with an older age, a shorter duration of the disorder and greater eating disorder psychopathology. Conclusions There is a notable variation in the physical activity profile of AN patients, characterized by either low or very high patterns. Physical activity is a highly relevant issue in AN that must be taken into account during the treatment process.
    Type of Medium: Online Resource
    ISSN: 0924-9338 , 1778-3585
    URL: Article
    DOI: 10.1016/j.eurpsy.2015.09.008
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2015
    detail.hit.zdb_id: 2005377-0
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  • 8
    Online Resource
    Online Resource
    Reasons for relapses in patients with schizophrenia admitted to acute units
    Cambridge University Press (CUP) ; 2011
    In:  European Psychiatry Vol. 26, No. S2 ( 2011-03), p. 1349-1349
    Details
    In: European Psychiatry, Cambridge University Press (CUP), Vol. 26, No. S2 ( 2011-03), p. 1349-1349
    Abstract: Relapses are common and a higher number of relapses involve a greater cognitive impairment of the patient. Prevention of relapses is therefore the primary objective of treatment. Objectives To establish why a sample of patients with schizophrenia experience relapses and are admitted to acute units as a result. Methods A multicenter, naturalistic, retrospective study assessing medical intervention in 1346 patients with schizophrenia admitted to acute units in Spain, assessing the following causes of relapses: non-compliance, lack of efficacy, drug abuse, stress and high incidence of side effects. Results 90.8% of patients were admitted for relapse. Reasons for admission were non-compliance in 67.1% (77.2% due to lack of insight and 30.59% due to drug abuse), lack of therapeutic efficacy in 27.2%, and drug abuse in 24.3%. In addition, stress and a high incidence of side effects in 5.8% of patients were other reasons for relapse. Conclusions Non compliance is the main reason for relapses followed by lack of efficacy. The results appear to confirm that drug abuse might influence in a direct (drug abuse itself) or indirect (non compliance because of drug abuse) way in a higher number of relapses.
    Type of Medium: Online Resource
    ISSN: 0924-9338 , 1778-3585
    URL: Article
    DOI: 10.1016/S0924-9338(11)73054-1
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2011
    detail.hit.zdb_id: 2005377-0
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  • 9
    Online Resource
    Online Resource
    Attitude of patients treated with antipsychotics at acute units
    Cambridge University Press (CUP) ; 2011
    In:  European Psychiatry Vol. 26, No. S2 ( 2011-03), p. 1351-1351
    Details
    In: European Psychiatry, Cambridge University Press (CUP), Vol. 26, No. S2 ( 2011-03), p. 1351-1351
    Abstract: Antipsychotic treatment and psychosocial interventions can reduce the risk of relapse and prevent functional impairment. The DAI questionnaire enables the effect of treatment perceived by patients to be evaluated. Objectives To assess the attitude of patients to treatment on hospital discharge compared when the drug of admission is modified on discharge and when it is maintained. Methods A multicenter, naturalistic, retrospective study to analyse the immediate clinical outcome after a medical intervention in 1346 patients with schizophrenia in acute units in Spain. Clinical progression of the first five days of hospital intervention and at hospital discharge was collected retrospectively. Afterwards, the DAI questionnaire was completed. Results 1238 patients completed the DAI questionnaire. The average score was 15.6 (range 10–20). In the group of patients where the main antipsychotic drug during hospital stay was the same as that received at the time of hospital discharge, no statistically significant differences were found vs the group where the antipsychotic was modified (15.6 vs 15.4, p = 0.630). Conclusion At acute units the effect of the drug perceived by patients assessed through the DAI questionnaire on hospital discharge is similar for all antipsychotic drugs whether the treatment is modified on hospital admission or not.
    Type of Medium: Online Resource
    ISSN: 0924-9338 , 1778-3585
    URL: Article
    DOI: 10.1016/S0924-9338(11)73056-5
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2011
    detail.hit.zdb_id: 2005377-0
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  • 10
    Online Resource
    Online Resource
    Commitment to sustainability in large European banks and its relationship with board gender diversity: a 2030 Agenda perspective
    Cambridge University Press (CUP) ; 2023
    In:  Journal of Management & Organization
    Details
    In: Journal of Management & Organization, Cambridge University Press (CUP)
    Abstract: Ensuring a sustainable future by meeting the Sustainable Development Goals (SDGs) cannot be achieved without women's empowerment and gender equality. This study aims to determine whether there are differences between European banks in terms of their commitment to SDGs and the intensity of this commitment depending on their board gender diversity. A sample of the 50 largest European banks from 2016 to 2020 was used to perform hypothesis testing for differences in means. The results provide robust support for the assertion that banks with greater female representation on the board of directors have a greater commitment to the 2030 Agenda. The originality of this research lies in the use of indicators of commitment to SDGs corresponding to each of the five SDG pillars. This study thus provides the first evidence of the importance of distinguishing between these pillars when examining the relationship between commitment to SDGs and board gender diversity. This evidence advances the scant literature on this relationship.
    Type of Medium: Online Resource
    ISSN: 1833-3672 , 1839-3527
    URL: Article
    DOI: 10.1017/jmo.2022.94
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2375897-1
    SSG: 3,2
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