In:
EMBO Molecular Medicine, EMBO, Vol. 14, No. 12 ( 2022-12-07)
Abstract:
image This study highlights the importance of metabolic symbiosis dependent on lactate and lactate dehydrogenase isoforms (LDHA and B) in glioblastoma development. Inhibiting both lactate dehydrogenases may be a novel potential therapeutic approach for targeting glioblastoma. Lactate, which is produced in hypoxic environments, is secreted and taken up by oxidative cells to fuel the Krebs cycle to promote growth and invasion. Only double knockout of LDHA/B abolished lactate production, reduced tumor growth and invasion, and prolonged mouse survival. Tumors that no longer express LDH become more oxidative and more sensitive to radiation. The use of the LDH inhibitor stiripentol in clinical practice may be therapeutically relevant for glioblastoma.
Type of Medium:
Online Resource
ISSN:
1757-4676
,
1757-4684
DOI:
10.15252/emmm.202115343
Language:
English
Publisher:
EMBO
Publication Date:
2022
detail.hit.zdb_id:
2485479-7
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