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  • 1
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 92, No. 11 ( 2004), p. 1108-1113
    Abstract: High heparin cofactor II (HCII) activity has recently been described to protect from coronary instent restenosis, presumably by inactivating thrombin in injured arteries. In this study, we investigated the association of HCII activity and restenosis after femoropopliteal stenting. We studied 63 consecutive patients with peripheral artery disease who underwent femoropopliteal stent implantation after initial failure of plain balloon angioplasty due to a significant residual stenosis ( 〉 30% lumen diameter reduction) or a flow limiting dissection. HCII activity was measured before stenting and patients were followed for median 10 months (interquartile range 6 to 17) for the occurrence of a first instent restenosis, defined as a 〉 50% lumen diameter reduction by color coded duplex sonography and confirmed by angiography. Cumulative freedom from restenosis at 6 and 12 months in patients with lower HCII activity (≤100%, lower tertile, n=20) was 84% and 35% as compared to 93% and 72% in patients with high HCII activity ( 〉 100%, middle and upper tertile, n=43; p=0.024 by Log Rank test). Adjusting for the material of the implanted stents (nitinol vs.Wallstents), patients with a high HCII activity had a 0.39-fold reduced risk for instent restenosis (95% CI 0.17 to 0.90, p=0.028), additional adjustment for diabetes mellitus, poor run-off, critical limb ischemia and cumulative length of the stented segment did not alter the observed effect. Higher activity of heparin cofactor II may exert a protective effect against instent restenosis also in the femoropopliteal vessel area, confirming a prior observation after coronary stenting.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2004
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  • 2
    In: Geburtshilfe und Frauenheilkunde, Georg Thieme Verlag KG, Vol. 82, No. 04 ( 2022-04), p. 427-440
    Abstract: Introduction The COVID-19 pandemic has been the cause of drastic measures within the national health system. This led us to analyze the clinical and economic performance indicators for gynecology and obstetrics services at the University Hospital of Marburg, which is one of the regional maximum care university hospitals. Therefore, we evaluated the impact of the pandemic on monthly inpatient and outpatient case numbers and the associated ICD and DRG codes, in order to identify any shortcomings in the care provided. Methods and Materials The study is based on a retrospective analysis of data relating to inpatient and outpatient cases that received treatment from 2016 to 2020. We used QlikView, the hospital’s internal performance monitoring program, to evaluate the data from 9487 cases from the gynecology department and 19597 cases from the obstetrics department. Results In line with the nationwide dynamics of the pandemic, we observed a 6% drop in the number of inpatient gynecology cases, while the volume of obstetrics cases rose by 11% in 2020. Overall, the impact on outpatient services was less severe. We also observed a location-specific drop in the number of C50 “malignant neoplasm of breast” cases by 7.4%, and a 14% drop in the number of C56 “malignant neoplasm of ovary” cases. A return to the level of service delivered in the previous year was achieved in three months for outpatient services, and in five months for inpatient services. Conclusion The negative effects of the COVID-19 pandemic primarily affected the gynecology clinic. An increase in obstetrics cases was achieved due to public trust in the safety of the university hospital care, and the service offered of allowing prospective fathers to take part in the birthing process following a rapid test. The return to a pre-pandemic level of service continues to be sluggish, while the outpatient sector, which was less affected in the first place, is showing a more rapid recovery. The location-specific decrease in C50 and C56 diagnoses is concerning, and needs to be assessed from an epidemiological perspective. The impact of the pandemic on case numbers is also reflected in the financial performance indicators.
    Type of Medium: Online Resource
    ISSN: 0016-5751 , 1438-8804
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
    detail.hit.zdb_id: 2026496-3
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  • 3
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2020
    In:  Laryngo-Rhino-Otologie Vol. 99, No. 11 ( 2020-11), p. 795-802
    In: Laryngo-Rhino-Otologie, Georg Thieme Verlag KG, Vol. 99, No. 11 ( 2020-11), p. 795-802
    Abstract: Hintergrund Berufsbildungswerke (BBW) sind Einrichtungen der beruflichen Rehabilitation und Bildung, vergleichbar mit Förderschulen im schulischen Bereich. Das BBW Leipzig registriert seit einigen Jahren eine zunehmende Anzahl von Jugendlichen mit der Diagnose auditive Verarbeitungs- und Wahrnehmungsstörung (AVWS). Für diese Zielgruppe gibt es derzeit nur wenige Testverfahren mit Referenz- oder Normwerten. Ziel war die Untersuchung der auditiven Verarbeitung und Wahrnehmung von peripher hörgesunden Jugendlichen mit vorhandenem Testmaterial. Material und Methoden 35 normalhörende Jugendliche (26 männlich, 9 weiblich, im Mittel 18,1 Jahre) aus dem BBW Leipzig wurden mit folgenden Tests untersucht: dichotisches Hören, Sprachverstehen im Störgeräusch, Verstehen zeitkomprimierter Sprache, Phonem-Differenzierung und -Analyse. Zusätzlich wurden sprachfreie Intelligenz, Konzentration, figurale Merkfähigkeit und die sprachlichen Leistungen getestet. Ergebnisse 25 Jugendliche zeigten zentral-auditive Auffälligkeiten; 5 von ihnen hatten keine AVWS-Diagnose aus der Kindheit. Bei 9 der 25 Jugendlichen konnten die Auffälligkeiten nicht auf übergeordnete Störungen zurückgeführt werden. Diese Jugendlichen waren vor allem in der Wahrnehmung gesprochener Sprache sowie im Halten und Manipulieren sprachlicher Reize im Arbeitsgedächtnis eingeschränkt, obwohl die sprachlichen Fähigkeiten unauffällig waren und die Intelligenz normal bis überdurchschnittlich war. Diskussion Die Ergebnisse zeigen, dass Jugendliche auffällig im Sinne der AVWS-Kriterien der DGPP sein können und dass nicht zwingend schon eine AVWS-Diagnose aus der Kindheit vorliegen muss. Außerdem wurde deutlich, dass die multiprofessionelle Diagnostik wichtig bleibt. Standardisierte Testverfahren mit entsprechenden Altersnormen werden benötigt.
    Type of Medium: Online Resource
    ISSN: 0935-8943 , 1438-8685
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2020
    detail.hit.zdb_id: 2037508-6
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