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  • Institute of Physiology of the Czech Academy of Sciences  (17)
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  • Institute of Physiology of the Czech Academy of Sciences  (17)
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  • 1
    Online Resource
    Online Resource
    Puncture vine (Tribulus Terrestris L.) in control of health and reproduction
    Institute of Physiology of the Czech Academy of Sciences ; 2021
    In:  Physiological Research
    Details
    In: Physiological Research, Institute of Physiology of the Czech Academy of Sciences
    Abstract: Tribulus terrestris, L. (puncture vine) have been used as a folk medicine for five thousands of years, but its targets, effects, their mechanisms and application requires further studies. This paper reviews the provenance, constituents and properties of Tribulus terrestris, L., its general physiological and health effects, as well as the currently available knowledge concerning its influence on male and female reproductive processes and their dysfunctions. Analysis of the available publications demonstrated the influence of Tribulus terrestris on a wide spectrum of targets and physiological processe and disorders. In particular, Tribulus terrestris can be a stimulator of male and female reproductive processes at the level of central nervous system, sexual behaviour, pituitary and gonadal hormones and their receptors, gonadal functions (including ovarian follicullogenesis and spermatogenesis), improvement of the quality and quantity of gametes (at least of sperm) and fecundity. This ability of puncture vine is applicable for the improvement of man’s sexual desire and sperm quality in vivo and in vitro, as well as of women’s libido, activation of women’s reproductive organs, fecundity, and treatment of infertility, especially that related to the polycystic ovarian syndrome.
    Type of Medium: Online Resource
    ISSN: 1802-9973 , 0862-8408
    URL: Journal
    URL: Article
    DOI: 10.33549/physiolres
    DOI: 10.33549/physiolres.934711
    Language: English
    Publisher: Institute of Physiology of the Czech Academy of Sciences
    Publication Date: 2021
    detail.hit.zdb_id: 2100162-5
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    FSH, Oxytocin and IGF-I Regulate the Expression of Sirtuin 1 in Porcine Ovarian Granulosa Cells
    Institute of Physiology of the Czech Academy of Sciences ; 2020
    In:  Physiological Research
    Details
    In: Physiological Research, Institute of Physiology of the Czech Academy of Sciences
    Abstract: The involvement of the mTOR system/enzyme sirtuin 1 (SIRT1) intracellular signaling system in the control of ovarian functions and its role in mediating hormonal action on the ovary has been proposed, but this hypothesis should be supported by a demonstrated influence of hormones on mTOR/SIRT1. Therefore, the aim of our in vitro experiments was to examine the effect of the known hormonal regulators of ovarian functions, such as follicle-stimulating hormone (FSH), oxytocin (OT) and insulin-like growth factor I (IGF-I), on mTOR/SIRT1. The accumulation of SIRT1 in porcine ovarian granulosa cells cultured with and without these hormones (at doses of 1, 10 or 100 ng.ml-1) was evaluated using immunocytochemistry. It was observed that the addition of FSH (at 10 ng.ml-1 but not at 1 or 100 ng/ml) and OT (at all tested doses) increased the expression of SIRT1 in ovarian cells. In addition, 100 ng.ml-1, but not at 1 or 10 ng.ml-1, of IGF-I decreased SIRT1 accumulation. Our observations are the first demonstration that hormones can directly regulate the ovarian mTOR/SIRT1 system and that this system could mediate the action of hormonal regulators on the ovary.
    Type of Medium: Online Resource
    ISSN: 1802-9973 , 0862-8408
    URL: Journal
    URL: Article
    DOI: 10.33549/physiolres
    DOI: 10.33549/physiolres.934424
    Language: English
    Publisher: Institute of Physiology of the Czech Academy of Sciences
    Publication Date: 2020
    detail.hit.zdb_id: 2100162-5
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Puncture vine (Tribulus Terrestris L.) in control of health and reproduction
    Institute of Physiology of the Czech Academy of Sciences ; 2021
    In:  Physiological Research , No. S4 ( 2021-12-30), p. S657-S667
    Details
    In: Physiological Research, Institute of Physiology of the Czech Academy of Sciences, , No. S4 ( 2021-12-30), p. S657-S667
    Abstract: Tribulus terrestris, L. (puncture vine) have been used as a folk medicine for five thousands of years, but its targets, effects, their mechanisms and application requires further studies. This paper reviews the provenance, constituents and properties of Tribulus terrestris, L., its general physiological and health effects, as well as the currently available knowledge concerning its influence on male and female reproductive processes and their dysfunctions. Analysis of the available publications demonstrated the influence of Tribulus terrestris on a wide spectrum of targets and physiological processe and disorders. In particular, Tribulus terrestris can be a stimulator of male and female reproductive processes at the level of central nervous system, sexual behaviour, pituitary and gonadal hormones and their receptors, gonadal functions (including ovarian follicullogenesis and spermatogenesis), improvement of the quality and quantity of gametes (at least of sperm) and fecundity. This ability of puncture vine is applicable for the improvement of man’s sexual desire and sperm quality in vivo and in vitro, as well as of women’s libido, activation of women’s reproductive organs, fecundity, and treatment of infertility, especially that related to the polycystic ovarian syndrome.
    Type of Medium: Online Resource
    ISSN: 1802-9973 , 0862-8408
    URL: Journal
    URL: Article
    DOI: 10.33549/physiolres
    DOI: 10.33549//physiolres.934711
    Language: English
    Publisher: Institute of Physiology of the Czech Academy of Sciences
    Publication Date: 2021
    detail.hit.zdb_id: 2100162-5
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Three medicinal plants affecting human ovarian cell viability, hormone release, and response to environmental contaminant toluene
    Institute of Physiology of the Czech Academy of Sciences ; 2023
    In:  Physiological Research , No. Vol 72(2) ( 2023-4-30), p. 259-268
    Details
    In: Physiological Research, Institute of Physiology of the Czech Academy of Sciences, , No. Vol 72(2) ( 2023-4-30), p. 259-268
    Abstract: The present study examined the effect of medicinal plants - ginkgo, tribulus (puncture vine), and yucca - on ovarian functions and their response to the toxic influence of toluene. Therefore, we analyzed the effect of toluene with and without these plant extracts on cultured human ovarian granulosa cells. Cell viability and the release of progesterone, insulin-like growth factor I (IGF I), oxytocin, and prostaglandin F (PGF) were analyzed using the trypan blue test, enzyme immunoassay, and enzyme-linked immunosorbent assay, respectively. The ginkgo, tribulus and yucca were able to suppress ovarian cell viability and alter the release of hormones. Toluene suppressed cell viability and the release of PGF, but not of progesterone, IGF-I, or oxytocin. The negative effect of toluene on cell viability was prevented and even reversed by ginkgo and yucca, whereas its effect on PGF was prevented or inverted by all tested plant extracts. These findings (1) demonstrated the direct toxic effect of toluene on ovarian cells, (2) showed the direct effect of some medicinal plants on ovarian cell functions, and (3) demonstrated the ability of these plants to inhibit the effects of toluene and to act as natural protectors against the suppressive effect of toluene on female reproduction.
    Type of Medium: Online Resource
    ISSN: 1802-9973 , 0862-8408
    URL: Journal
    URL: Article
    DOI: 10.33549/physiolres
    DOI: 10.33549/physiolres.934986
    Language: English
    Publisher: Institute of Physiology of the Czech Academy of Sciences
    Publication Date: 2023
    detail.hit.zdb_id: 2100162-5
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    The Effect of Dietary Oat Consumption and Its Constituents on Fat Storage and Obesity
    Institute of Physiology of the Czech Academy of Sciences ; 2023
    In:  Physiological Research
    Details
    In: Physiological Research, Institute of Physiology of the Czech Academy of Sciences
    Abstract: This review is to summarize and analyze the currently available knowledge concerning the action of oat (Avena sativa L.) consumption on obesity, as well as possible constituents and extra- and intracellular mediators responsible for its anti-obesity effect. The oat constituents could reduce fat storage via several mediatory mechanisms – brain centers regulating appetite, gastrointestinal functions, gut bacteria, fat synthesis and metabolism and maybe via changes in oxidative processes, steroid hormones receptors and adipose tissue vascularization. Several oat constituents (starch, fiber and beta-glucan) could have anti-obesity properties, whilst one oat constituent (starch or fiber) could affect fat storage via several mechanisms of action.
    Type of Medium: Online Resource
    ISSN: 1802-9973 , 0862-8408
    URL: Journal
    URL: Article
    DOI: 10.33549/physiolres
    DOI: 10.33549/physiolres.934957
    Language: English
    Publisher: Institute of Physiology of the Czech Academy of Sciences
    Publication Date: 2023
    detail.hit.zdb_id: 2100162-5
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Metabolic Status and Ghrelin Regulate Plasma Levels and Release of Ovarian Hormones in Layer Chicks
    Institute of Physiology of the Czech Academy of Sciences ; 2017
    In:  Physiological Research
    Details
    In: Physiological Research, Institute of Physiology of the Czech Academy of Sciences
    Abstract: The aim of the present study was to examine the role of nutritional status, the metabolic hormone ghrelin and their interrelationships in the control of chicken hormones involved in the regulation of reproduction. For this purpose, we identified the effect of food deprivation, administration of ghrelin 1-18 and their combination on plasma levels of testosterone (T), estradiol (E), arginine-vasotocin (AVT) and growth hormone (GH) as well as the release of these hormones by isolated and cultured ovarian fragments. It was observed that food deprivation reduces plasma T and E and increases plasma AVT and GH levels. Food restriction also reduced the amount of E produced by isolated ovaries, but it did not affect the ovarian secretion of T and AVT. No ovarian GH secretion was detected. Ghrelin administered to ad libitum fed chickens did not affect plasma T and E levels, but it did increase plasma GH and AVT concentrations. Moreover, it partially prevented the effect of food deprivation on plasma E and AVT levels, but not on T or GH levels. Ghrelin administration to control birds promoted ovarian T, but not E or AVT release and reduced T and no other hormonal outputs in birds subjected to food restriction. Our results (1) confirmed the ovarian origin of the main plasma T and E and the extra-ovarian origin of the main blood AVT and GH; (2) showed that food deprivation-induced suppression of reproduction may be caused by suppression of T and E and the promotion of AVT and GH release; (3) suggest the involvement of ghrelin in control chicken E, AVT and GH output; and (4) indicates that ghrelin can either mimic or modify the effect of the intake of low calories on chicken plasma and ovarian hormones, i.e. it can mediate the effect of metabolic state on hormones involved in the control of reproduction.
    Type of Medium: Online Resource
    ISSN: 1802-9973 , 0862-8408
    URL: Journal
    URL: Article
    DOI: 10.33549/physiolres
    DOI: 10.33549/physiolres.933306
    Language: English
    Publisher: Institute of Physiology of the Czech Academy of Sciences
    Publication Date: 2017
    detail.hit.zdb_id: 2100162-5
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Some endocrine traits of transgenic rabbits. I. Changes in plasma and milk hormones
    Institute of Physiology of the Czech Academy of Sciences ; 2008
    In:  Physiological Research
    Details
    In: Physiological Research, Institute of Physiology of the Czech Academy of Sciences
    Abstract: The aim of these studies was to compare some endocrine and non-endocrine characteristics of transgenic (carrying mammary gland-specific mWAP-hFVIII gene construct) and non-transgenic rabbits. The concentrations of corticosterone, progesterone, testosterone, estradiol, insulin-like growth factor I (IGF-I) and human factor VIII (hFVIII) in the blood plasma of adult females (9 months of age, 3rd generation transgenic animals), adult males, and young females (1-2 months of age, 4th generation of transgenic animals), as well as in the milk of lactating adult females, were analyzed by using RIA. In addition, litter size and body mass of pups born by transgenic and non-transgenic females from the 3rd generation were compared. Transgenic animals were compared with their non-transgenic siblings (the same genetic and epigenetic background). Transgenesis did not influence plasma hFVIII, but significantly increased corticosterone (in all animals), reduced IGF-I (in adult males and females), testosterone and estradiol, (in young females) and altered progesterone (increase in adult males and decrease in adult females) concentrations in blood plasma. In addition, transgenic females had higher milk concentrations of testosterone, but not progesterone or IGF-I than their nontransgenic sisters. These endocrine changes were not associated with changes in litter size. Transgenic male (but not female) pups have smaller body mass than control animals. These observations demonstrate the influence of transgenesis per se on the animal growth and endocrine system (secretion of reproductive and stress steroid hormones as well as growth factors) over four generations.
    Type of Medium: Online Resource
    ISSN: 1802-9973 , 0862-8408
    URL: Journal
    URL: Article
    DOI: 10.33549/physiolres
    DOI: 10.33549/physiolres.931149
    Language: English
    Publisher: Institute of Physiology of the Czech Academy of Sciences
    Publication Date: 2008
    detail.hit.zdb_id: 2100162-5
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    In Vitro Changes in Secretion Activity of Rat Ovarian Fragments Induced by Molybdenum
    Institute of Physiology of the Czech Academy of Sciences ; 2014
    In:  Physiological Research
    Details
    In: Physiological Research, Institute of Physiology of the Czech Academy of Sciences
    Abstract: The aim of this in vitro study was to examine the secretion activity (progesterone, 17β-estradiol and insulin-like growth factor-I) of rat ovarian fragments after molybdenum (Mo) addition. Rat ovarian fragments were incubated with ammonium molybdate (NH4)6Mo7O24.4H2O at the doses 90, 170, 330 and 500 µg.ml-1 for 24 h and compared with control group without Mo addition. Release of progesterone (P4), estradiol (17β-estradiol) and insulin-like growth factor I (IGF-I) by ovarian fragments was assessed by radioimmunoassay (RIA). Data show that P4 release by ovarian fragments was not affected by (NH4)6.Mo7O24.4H2O addition at all the doses used (90-500 µg.ml-1). However, addition of ammonium molybdate was found to cause a significant (P 〈 0.05) dose-dependent decrease (at the doses 90, 170 and 500 µg.ml-1) in release of 17β-estradiol by ovarian fragments in comparison to control. Also, addition of ammonium molybdate significantly (P 〈 0.05) inhibited IGF-I release at all the doses (90-500 µg.ml-1) used in the study. Results suggest ammonium molybdate induced inhibition in the release of growth factor IGF-I and its dose-dependent effect on secretion of steroid hormone 17β-estradiol but not progesterone. These data contribute to new insights regarding the mechanism of action of Mo on rat ovarian functions.
    Type of Medium: Online Resource
    ISSN: 1802-9973 , 0862-8408
    URL: Journal
    URL: Article
    DOI: 10.33549/physiolres
    DOI: 10.33549/physiolres.932836
    Language: English
    Publisher: Institute of Physiology of the Czech Academy of Sciences
    Publication Date: 2014
    detail.hit.zdb_id: 2100162-5
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Leptin affects proliferation-, apoptosis- and protein kinase A-related peptides in human ovarian granulosa cells
    Institute of Physiology of the Czech Academy of Sciences ; 2008
    In:  Physiological Research
    Details
    In: Physiological Research, Institute of Physiology of the Czech Academy of Sciences
    Abstract: The aim of our in vitro studies was to understand the role of leptin in controlling proliferation, apoptosis, and protein kinase A (PKA) in human ovarian cells. We analyzed the in vitro effects of leptin (0, 1, 10 or 100 ng/ml) on the accumulation of proliferation-related peptides (PCNA, cyclin B1), apoptosisassociated peptide (Bax) and the intracellular signaling molecule PKA in cultured human granulosa cells using immunocytochemistry and Western immunoblotting. It was observed that leptin stimulated in a dose-dependent manner the accumulation of PCNA (at doses 1-100 ng/ml), cyclin B1 (at doses 10 or 100 ng/ml), Bax (at doses 10 or 100 ng/ml) and PKA (at doses 1-100 ng/ml) in cultured human ovarian cells. These observations suggest the ability of leptin to control directly human ovarian cell functions: proliferation, apoptosis, and intracellular messenger PKA.
    Type of Medium: Online Resource
    ISSN: 1802-9973 , 0862-8408
    URL: Journal
    URL: Article
    DOI: 10.33549/physiolres
    DOI: 10.33549/physiolres.931153
    Language: English
    Publisher: Institute of Physiology of the Czech Academy of Sciences
    Publication Date: 2008
    detail.hit.zdb_id: 2100162-5
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    Some endocrine traits of transgenic rabbits. II. Changes in hormone secretion and response of isolated ovarian tissue to FSH and ghrelin
    Institute of Physiology of the Czech Academy of Sciences ; 2008
    In:  Physiological Research
    Details
    In: Physiological Research, Institute of Physiology of the Czech Academy of Sciences
    Abstract: In the present in vitro experiments we examined FSH- and ghrelin-induced changes in ovarian hormone secretion by transgenic rabbits. Fragments of ovaries isolated from adult transgenic (carrying mammary gland-specific mWAP-hFVIII gene) and non-transgenic rabbits from the same litter were cultured with and without FSH or ghrelin (both at 0, 1, 10 or 100 ng/ml medium). The secretion of progesterone (P4), estradiol (E2) and insulin-like growth factor I (IGF-I) was assessed by RIA. It was observed that ovaries isolated from transgenic rabbits secreted much less P4, E2 and IGF-I than the ovaries of nontransgenic animals. In control animals FSH reduced E2 (at doses 1-100 ng/ml medium) and IGF-I (at 1-100 ng/ml), but not P4 secretion, whereas ghrelin promoted P4 (at 1 ng/ml) and IGF-I (at 100 ng/ml), but not E2 output. In transgenic animals, the effects were reversed: FSH had a stimulatory effect on E2 (at 100 ng/ml) and ghrelin had an inhibitory effect on P4 (at 10 ng/ml). No differences in the pattern of influence of FSH on P4 and IGF-I and of ghrelin on E2 and IGF-I were found between control and transgenic animals. The present observations suggest that 1) both FSH and ghrelin are involved in rabbit ovarian hormone secretion, 2) transgenesis in rabbits is associated with a reduction in ovarian secretory activity, and 3) transgenesis can affect the response of ovarian cells to hormonal regulators.
    Type of Medium: Online Resource
    ISSN: 1802-9973 , 0862-8408
    URL: Journal
    URL: Article
    DOI: 10.33549/physiolres
    DOI: 10.33549/physiolres.931150
    Language: English
    Publisher: Institute of Physiology of the Czech Academy of Sciences
    Publication Date: 2008
    detail.hit.zdb_id: 2100162-5
    SSG: 12
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