In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 2 ( 2023-2-9), p. e0278561-
Abstract:
The newly introduced Cellular Oxygen METabolism (COMET ® ) monitor enables the measurement of mitochondrial oxygen tension (mitoPO 2 ) using the protoporphyrin IX triplet state lifetime technique (PpIX-TSLT). This study aims to investigate the feasibility and applicability of the COMET ® measurements in the operating theatre and study the behavior of the new parameter mitoPO2 during stable operating conditions. Methods In this observational study mitochondrial oxygenation was measured in 20 patients during neurosurgical procedures using the COMET ® device. Tissue oxygenation and local blood flow were measured by the Oxygen to See (O2C). Primary outcomes included mitoPO 2 , skin temperature, mean arterial blood pressure, local blood flow and tissue oxygenation. Results All patients remained hemodynamically stable during surgery. Mean baseline mitoPO 2 was 60 ± 19 mmHg (mean ± SD) and mean mitoPO 2 remained between 40–60 mmHg during surgery, but tended to decrease over time in line with increasing skin temperature. Conclusion This study presents the feasibility of mitochondrial oxygenation measurements as measured by the COMET ® monitor in the operating theatre and shows the parameter mitoPO 2 to behave in a stable and predictable way in the absence of notable hemodynamic alterations. The results provide a solid base for further research into the added value of mitochondrial oxygenation measurements in the perioperative trajectory.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0278561
DOI:
10.1371/journal.pone.0278561.g001
DOI:
10.1371/journal.pone.0278561.g002
DOI:
10.1371/journal.pone.0278561.g003
DOI:
10.1371/journal.pone.0278561.g004
DOI:
10.1371/journal.pone.0278561.t001
DOI:
10.1371/journal.pone.0278561.s001
DOI:
10.1371/journal.pone.0278561.s002
DOI:
10.1371/journal.pone.0278561.s003
DOI:
10.1371/journal.pone.0278561.s004
DOI:
10.1371/journal.pone.0278561.s005
DOI:
10.1371/journal.pone.0278561.s006
DOI:
10.1371/journal.pone.0278561.s007
DOI:
10.1371/journal.pone.0278561.r001
DOI:
10.1371/journal.pone.0278561.r002
DOI:
10.1371/journal.pone.0278561.r003
DOI:
10.1371/journal.pone.0278561.r004
DOI:
10.1371/journal.pone.0278561.r005
DOI:
10.1371/journal.pone.0278561.r006
DOI:
10.1371/journal.pone.0278561.r007
DOI:
10.1371/journal.pone.0278561.r008
DOI:
10.1371/journal.pone.0278561.r009
DOI:
10.1371/journal.pone.0278561.r010
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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